{{Short description|G-protein coupled receptor}} {{Pfam_box | Symbol = Latrophilin | Name = Latrophilin | image = | width = | caption = | Pfam= PF02354 | InterPro= IPR003334 | SMART= | Prosite = | SCOP = | TCDB = | OPM family= | OPM protein= | PDB= }} {{infobox protein | Name = EGF, latrophilin and seven transmembrane domain containing 1 | caption = | image = | width = | HGNCid = 20822 | Symbol = ELTD1 | AltSymbols = ETL | EntrezGene = 64123 | OMIM = | RefSeq = NM_022159 | UniProt = Q9HBW9 | PDB = | ECnumber = | Chromosome = 1 | Arm = p33 | Band = -p32 | LocusSupplementaryData = }} {{infobox protein | Name = latrophilin 1 | caption = | image = | width = | HGNCid = 20973 | Symbol = LPHN1 | AltSymbols = KIAA0821, CIRL1, LEC2 | EntrezGene = 22859 | OMIM = | RefSeq = NM_014921 | UniProt = O94910 | PDB = | ECnumber = | Chromosome = 19 | Arm = p | Band = 13.2 | LocusSupplementaryData = }} {{infobox protein | Name = latrophilin 2 | caption = | image = | width = | HGNCid = 18582 | Symbol = LPHN2 | AltSymbols = LPHH1, KIAA0786, LEC1 | EntrezGene = 23266 | OMIM = 607018 | RefSeq = NM_012302 | UniProt = O95490 | PDB = | ECnumber = | Chromosome = 1 | Arm = p | Band = 31.1 | LocusSupplementaryData = }} {{infobox protein | Name = latrophilin 3 | caption = | image = | width = | HGNCid = 20974 | Symbol = LPHN3 | AltSymbols = KIAA0768, LEC3 | EntrezGene = 23284 | OMIM = | RefSeq = NM_015236 | UniProt = Q9HAR2 | PDB = | ECnumber = | Chromosome = 4 | Arm = q | Band = 13.1 | LocusSupplementaryData = }} '''Latrophilins''' are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind to a component of black widow spider venom known as alpha-latrotoxin.<ref name="pmid12196116">{{cite journal |vauthors=Kreienkamp HJ, Soltau M, Richter D, Böckers T | title = Interaction of G-protein-coupled receptors with synaptic scaffolding proteins | journal = Biochem. Soc. Trans. | volume = 30 | issue = 4 | pages = 464–8 | year = 2002 | pmid = 12196116 | doi = 10.1042/BST0300464| url = http://www.biochemsoctrans.org/bst/030/bst0300464.htm| url-access = subscription }}</ref> This conserved family of membrane proteins has up to three homologues in chordate species, including humans.<ref name="JPS">{{cite book|last1=Silva|first1=JP|last2=Ushkaryov|first2=YA|title=Adhesion-GPCRS |chapter=The Latrophilins, "Split-Personality" Receptors |series=Advances in Experimental Medicine and Biology |date=2010|volume=706|pages=59–75|pmid=21618826|pmc=3145135|doi=10.1007/978-1-4419-7913-1_5|isbn=978-1-4419-7912-4}}</ref>
The precise functions of latrophilins remain unknown.<ref name="JPS" /> Genetic defects in latrophilin genes have been associated with diseases such as attention-deficit hyperactivity disorder and cancer.<ref>{{cite journal|last1=Meza-Aguilar|first1=Diana G|last2=Boucard|first2=Antony A|title=Latrophilins updated|journal=Biomolecular Concepts|date=1 January 2014|volume=5|issue=6|pages=457–478|doi=10.1515/bmc-2014-0032|pmid=25429599|s2cid=207442054|doi-access=free}}</ref>
==Human proteins containing this domain == * Latrophilin 1 (LPHN1) * Latrophilin 2 (LPHN2) * Latrophilin 3 (LPHN3)
==See also== * ELTD1
==References== {{Reflist|2}}
{{G protein-coupled receptors}} {{Acetylcholine metabolism and transport modulators}}
Category:Latrophilins