{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Latrophilin 1''' is a protein that in humans is encoded by the ''ADGRL1'' gene.<ref name="pmid10994649">{{cite journal | vauthors = Hayflick JS | title = A family of heptahelical receptors with adhesion-like domains: a marriage between two super families | journal = Journal of Receptor and Signal Transduction Research | volume = 20 | issue = 2–3 | pages = 119–131 | date = Jan 2001 | pmid = 10994649 | doi = 10.3109/10799890009150640 | s2cid = 19919738 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LPHN1 latrophilin 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=22859}}</ref> It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.<ref name="isbn1-4419-7912-3">{{cite book | author = Stacey M, Yona S | title = AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology) | publisher = Springer | location = Berlin | year = 2011 | isbn = 978-1-4419-7912-4 }}</ref><ref name="pmid12435584">{{cite journal | vauthors = Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB | title = Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions | journal = FEBS Letters | volume = 531 | issue = 3 | pages = 407–414 | date = November 2002 | pmid = 12435584 | doi = 10.1016/S0014-5793(02)03574-3 | bibcode = 2002FEBSL.531..407F | s2cid = 7449692 | doi-access = free }}</ref><ref name="pmid22333914">{{cite journal | vauthors = Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT | title = A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis | journal = The EMBO Journal | volume = 31 | issue = 6 | pages = 1364–1378 | date = March 2012 | pmid = 22333914 | pmc = 3321182 | doi = 10.1038/emboj.2012.26 }}</ref>
== Function ==
This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane.<ref name="entrez" /> Latrophilin-1 is involved in glucose sensing in the brain and regulating glucose intake.<ref name="Chhabra_2023">{{cite journal | vauthors = Chhabra KH, Bathina S, Faniyan TS, Samuel DJ, Raza MU, de Souza Cordeiro LM, Viana Di Prisco G, Atwood BK, Robles J, Bainbridge L, Davis A | display-authors = 6 | title = ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis | journal = Diabetologia | volume = 67| issue = 1| date = September 2023 | pages = 170–189 | pmid = 37712955 | doi = 10.1007/s00125-023-06010-6 | pmc = 10709246 | s2cid = 261886742 | doi-access = free }}</ref><ref>{{cite journal|vauthors= Stillwell JD, Elmi MA, Parag RR, Van Meir EG| title= Therapeutic targeting of adhesion GPCRs: a status update and future potential|year=2026|journal=Expert Opinion on Drug Discovery|volume=21|issue=5|page=447-463|doi=10.1080/17460441.2026.2662413|doi-access=free}}</ref>
== See also == * Adhesion G protein-coupled receptors
== References == {{reflist|2}}
== Further reading == {{refbegin|2}} * {{cite journal | vauthors = Südhof TC | title = alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins | journal = Annual Review of Neuroscience | volume = 24 | pages = 933–962 | year = 2001 | pmid = 11520923 | doi = 10.1146/annurev.neuro.24.1.933 }} * {{cite journal | vauthors = Ushkaryov YA, Volynski KE, Ashton AC | title = The multiple actions of black widow spider toxins and their selective use in neurosecretion studies | journal = Toxicon | volume = 43 | issue = 5 | pages = 527–542 | date = April 2004 | pmid = 15066411 | doi = 10.1016/j.toxicon.2004.02.008 | bibcode = 2004Txcn...43..527U }} * {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | display-authors = 6 | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 6 | pages = 355–364 | date = December 1998 | pmid = 10048485 | doi = 10.1093/dnares/5.6.355 | doi-access = free }} * {{cite journal | vauthors = Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM | title = The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins | journal = The Journal of Biological Chemistry | volume = 275 | issue = 42 | pages = 32387–32390 | date = October 2000 | pmid = 10964907 | doi = 10.1074/jbc.C000490200 | doi-access = free }} * {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry | journal = Analytical Chemistry | volume = 76 | issue = 10 | pages = 2763–2772 | date = May 2004 | pmid = 15144186 | doi = 10.1021/ac035352d | bibcode = 2004AnaCh..76.2763B }} * {{cite journal | vauthors = Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB | title = The human and mouse repertoire of the adhesion family of G-protein-coupled receptors | journal = Genomics | volume = 84 | issue = 1 | pages = 23–33 | date = July 2004 | pmid = 15203201 | doi = 10.1016/j.ygeno.2003.12.004 }} {{refend}}
== External links == * [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q80TR1 PDBe-KB] provides an overview of all the structure information available in the PDB for Mouse Adhesion G protein-coupled receptor L1
{{NLM content}} {{transmembranereceptor-stub}} {{Chemokine receptors}} {{G protein-coupled receptors|g2}}
Category:Latrophilins