{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Latrophilin 2''' is a protein that in humans is encoded by the ''ADGRL2'' gene.<ref name="pmid10760572">{{cite journal | vauthors = White GR, Varley JM, Heighway J | title = Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1491 | issue = 1–3 | pages = 75–92 | date = Apr 2000 | pmid = 10760572 | doi = 10.1016/s0167-4781(00)00020-8 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LPHN2 latrophilin 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23266}}</ref>
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.<ref name="entrez" />
== See also == * Adhesion G protein-coupled receptors
== References == {{reflist}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Südhof TC | title = alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins | journal = Annual Review of Neuroscience | volume = 24 | issue = 1 | pages = 933–62 | year = 2001 | pmid = 11520923 | doi = 10.1146/annurev.neuro.24.1.933 }} * {{cite journal | vauthors = Ushkaryov YA, Volynski KE, Ashton AC | title = The multiple actions of black widow spider toxins and their selective use in neurosecretion studies | journal = Toxicon | volume = 43 | issue = 5 | pages = 527–42 | date = Apr 2004 | pmid = 15066411 | doi = 10.1016/j.toxicon.2004.02.008 }} * {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }} * {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 5 | pages = 277–86 | date = Oct 1998 | pmid = 9872452 | doi = 10.1093/dnares/5.5.277 | doi-access = free }} * {{cite journal | vauthors = White GR, Varley JM, Heighway J | title = Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer | journal = Oncogene | volume = 17 | issue = 26 | pages = 3513–9 | date = Dec 1998 | pmid = 10030676 | doi = 10.1038/sj.onc.1202487 | doi-access = free }} * {{cite journal | vauthors = Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM | title = The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins | journal = The Journal of Biological Chemistry | volume = 275 | issue = 42 | pages = 32387–90 | date = Oct 2000 | pmid = 10964907 | doi = 10.1074/jbc.C000490200 | doi-access = free }} * {{cite journal | vauthors = Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB | title = The human and mouse repertoire of the adhesion family of G-protein-coupled receptors | journal = Genomics | volume = 84 | issue = 1 | pages = 23–33 | date = Jul 2004 | pmid = 15203201 | doi = 10.1016/j.ygeno.2003.12.004 }} * {{cite journal | vauthors = Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE | title = Discovery of tissue-specific exons using comprehensive human exon microarrays | journal = Genome Biology | volume = 8 | issue = 4 | pages = R64 | year = 2007 | pmid = 17456239 | pmc = 1896007 | doi = 10.1186/gb-2007-8-4-r64 | doi-access = free }} {{refend}}
{{transmembranereceptor-stub}} {{NLM content}} {{G protein-coupled receptors|g2}} Category:Latrophilins