Benzomorphan

{{chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 445992038 | ImageFile = Benzomorphan.png | ImageClass = skin-invert-image | ImageSize = 200px | IUPACName = 6,7-Benzomorphan | OtherNames = {{bulletedlist|1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine<|10-Azatricyclo[7.3.1.0~2,7~]trideca-2,4,6-triene}} |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo = 575-19-9 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = A8J3S2MS1D | PubChem = 182394 | SMILES = C1CNC2CC1C3=CC=CC=C3C2 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 158637 | InChI = 1/C12H15N/c1-2-4-12-9(3-1)7-11-8-10(12)5-6-13-11/h1-4,10-11,13H,5-8H2 | InChIKey = NSLKFRGZLUIUKO-UHFFFAOYAF | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C12H15N/c1-2-4-12-9(3-1)7-11-8-10(12)5-6-13-11/h1-4,10-11,13H,5-8H2 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = NSLKFRGZLUIUKO-UHFFFAOYSA-N }} |Section2={{Chembox Properties | C=12 | H=15 | N=1 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }}

'''Benzomorphan''' is a chemical compound that is the base for a series of drugs which variably act on the sigma receptors and κ-opioid receptors, including the following compounds:

{{colbegin|colwidth=18em}} * 5,9-DEHB *8-CAC * Alazocine * Anazocine * Bremazocine * Butinazocine * Carbazocine * Cogazocine * Cyclazocine * Dezocine * Eptazocine (Homobenzomorphan) * Etazocine * Ethylketocyclazocine * Fluorophen * Gemazocine * Gpa-1657 [14578-59-7]<ref>{{Cite journal |last1=Yokoyama |first1=Naokata |last2=Almaula |first2=Prabodh I. |last3=Block |first3=Fred B. |last4=Granat |first4=Frank R. |last5=Gottfried |first5=Norman |last6=Hill |first6=Ronald T. |last7=McMahon |first7=Elihu H. |last8=Munch |first8=Walter F. |last9=Rachlin |first9=Howard |date=1979 |title=Syntheses, analgetic activity and physical dependence capacity of 5-phenyl-6,7-benzomorphan derivatives |url=https://pubs.acs.org/doi/abs/10.1021/jm00191a016 |journal=Journal of Medicinal Chemistry |volume=22 |issue=5 |pages=537–553 |doi=10.1021/jm00191a016 |pmid=37335 |url-access=subscription }}</ref> * GPA 1658 HCl salt: [26862-29-3]<ref>{{Cite journal |last1=Yokoyama |first1=Naokata |last2=Block |first2=Fred B. |last3=Clarke |first3=Frank H. |date=1970 |title=1,2,3,4,5,6-Hexahydro-6-phenyl-2,6-methano-3-benzazocines. II |url=https://pubs.acs.org/doi/abs/10.1021/jm00297a034 |journal=Journal of Medicinal Chemistry |volume=13 |issue=3 |pages=488–492 |doi=10.1021/jm00297a034|url-access=subscription }}</ref> * [https://pubchem.ncbi.nlm.nih.gov/#query=GPA-208 GPA-208] * GPA-3154 Fb: [35758-34-0] HCl salt: [35758-32-8] * Ibazocine * ID-1229 [56390-16-0]<ref>{{cite journal |author=Castañer, J. |author2=Paton, D. M. | journal=Drugs of the Future | title=ID-1229 | volume=3 | issue=4 | page=298 | date= 1978 | url=http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=2&p_RefId=65215&p_IsPs=N | issn=0377-8282 | doi=10.1358/dof.1978.003.04.65215 | access-date=21 October 2025| url-access=subscription }}</ref><ref name="pmid1242327">{{cite journal | vauthors = Yamamoto H, Saito C, Inaba S, Inukai T, Kobayashi K | title = The synthesis and pharmacology of a new analgesic, ID-1229 | journal = Arzneimittel-Forschung | volume = 25 | issue = 5 | pages = 795–801 | date = May 1975 | pmid = 1242327 | doi = 10.1002/chin.197534266 | url = }}</ref><ref>{{cite journal | vauthors=Yamamoto, H, Saito, C, Inaba, S, Inukai, T, Kobayashi, K, Fukumaru, T, Koga, Y, Homma, T, Asami, Y | journal=Chemischer Informationsdienst | title=ChemInform Abstract: THE SYNTHESIS AND PHARMACOLOGY OF A NEW ANALGESIC, ID-1229 | volume=6 | issue=34 | article-number=chin.197534266 | date=26 August 1975 | url=https://onlinelibrary.wiley.com/doi/10.1002/chin.197534266 | issn=0009-2975 | doi=10.1002/chin.197534266 | pmid=1242327 | access-date=21 October 2025| url-access=subscription }}</ref> * [https://pubchem.ncbi.nlm.nih.gov/compound/123445395 LP-1]<ref>{{Cite journal |last1=Parenti |first1=Carmela |last2=Turnaturi |first2=Rita |last3=Aricò |first3=Giuseppina |last4=Marrazzo |first4=Agostino |last5=Prezzavento |first5=Orazio |last6=Ronsisvalle |first6=Simone |last7=Scoto |first7=Giovanna M. |last8=Ronsisvalle |first8=Giuseppe |last9=Pasquinucci |first9=Lorella |date=2012 |title=Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand |journal=Life Sciences |volume=90 |issue=25–26 |pages=957–961 |doi=10.1016/j.lfs.2012.04.041 |pmid=22580287}}</ref> * Ketazocine * Metazocine * Moxazocine * Mr2266 [56649-76-4] * MR-2034, MR-2033-CL [57236-85-8] * Pentazocine * Phenazocine * Quadazocine * Thiazocine{{Citation needed|date=October 2025}} * Tonazocine * Volazocine * Zenazocine {{colend}}

Some of these agents are used as analgesics, including pentazocine, phenazocine, dezocine, and eptazocine.<ref name="urlMedicinal Chemistry - Google Books">{{cite book | url = https://books.google.com/books?id=shXKUzLwUtIC&pg=PA257 | title = Medicinal Chemistry| isbn = 978-81-224-1565-0 | last1 = Kar | first1 = Ashutosh | year = 2005 | publisher = New Age International }}</ref><ref name="pmid2876100">{{cite journal |vauthors=Cittern PA, Kapoor VK, Parfitt RT | title = Preparation and analgesic activity of (−)-11 alpha-substituted 1,2,3,4,5,6-hexahydro-6 alpha,7-(methyleneoxy)-2,6-methano-3-benzazocines | journal = Journal of Medicinal Chemistry | volume = 29 | issue = 10 | pages = 1929–33 |date=October 1986 | pmid = 2876100 | doi = 10.1021/jm00160a022}}</ref>

== See also == * Benzazocine * Azocine * Morphinan

== References == {{Reflist|1}}

Category:Benzomorphans