HLA-DR13

{| id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="240px" |- | align="center" colspan="2" | 240px|Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen |- | align="center" colspan="2" | <div style="font-size:medium; line-height:120%;">major histocompatibility complex, class II, DR13</div> |- | bgcolor="#e7dcc3" | Haplotypes groups | bgcolor="#eeeeee" | DQA*01:DRB1*1301 to DQA*01:DRB1*1309 DQA*01:DRB1*1310 DQA*01:DRB1*1312 .... |- | colspan="2" bgcolor="#dddddd" | '''Structure''' (See HLA-DR) |-style="background:#f8f8f8" | bgcolor="#dddddd" | '''Identifiers'''|| align="center" | <div style="font-size:medium; line-height:120%;">alpha ''*0101''</div> |- | bgcolor="#e7dcc3" | Symbol(s) | bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC4947 HLA-DRA]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }} |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRA*0101 DRA*0101] |-style="background:#f8f8f8" | bgcolor="#dddddd" | '''Identifiers'''|| align="center" | <div style="font-size:medium; line-height:120%;">beta 1 ''*1301'' to ''*1308'' ''*1310''</div> |- | bgcolor="#e7dcc3" | Symbol(s) | bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=4953 HLA-DRB1]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }} |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1301 DRB1*1301] |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1302 DRB1*1302] {{Webarchive|url=https://web.archive.org/web/20110515170809/http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1302 |date=2011-05-15 }} |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1304 DRB1*1304] {{Webarchive|url=https://web.archive.org/web/20110515170846/http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1304 |date=2011-05-15 }} |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1306 DRB1*1306] |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1307 DRB1*1307] {{Webarchive|url=https://web.archive.org/web/20070926223620/http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1307 |date=2007-09-26 }} |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1310 DRB1*1310] |- | colspan="2" bgcolor="#dddddd" | '''Shared data''' |- | bgcolor="#e7dcc3" | Locus | bgcolor="#eeeeee" | chr.6 ''[https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31]'' |- |}

'''HLA-DR13'''(DR13) is a HLA-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR14 antigens.

==Alleles== {| border="0" cellspacing="0" cellpadding="0" align="center" style="text-align:center; background:#ffffff; margin-right: 1em; border:2px #e0e0ff solid;" |+ DR13, DR6 and other serotype recognition of some DRB1*13 alleles<ref>[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]</ref> |- style="background:#f0f0ff" | style="width:60px" | DRB1* || style="width:60px" | '''DR13''' | style="width:60px" | DR6 || style="width:60px" | DR14 || style="width:60px" | Sample |- style="background:#f0f0ff" | allele || % || % || % || size (N) |- | style = "background:#e8e8f8" | 1301 || 81 || 14 || 1 || 3788 |- | style = "background:#e8e8f8" | 1302 || 74 || 17 || 2 || 3081 |- | style = "background:#e8e8f8" | 1303 || 69 || 10 || 2 || 948<ref>DR12 - 3%, DR11 - 3% DR5-2%</ref> |- | style = "background:#e8e8f8" | 1304 || 87 || || || 127 |- | style = "background:#e8e8f8" | 1305 || 54 || 12 || || 305<ref>DR12 - 6%, DR11 - 7% DR5-4%</ref> |- | style = "background:#e8e8f8" | 1306 || 78 || || || 9 |- | style = "background:#e8e8f8" | 1307 || >50 || || || 1 |- | style = "background:#e8e8f8" | 1308 || 45 || 55 || || 9 |- | style = "background:#e8e8f8" | 1310 || >75 || || || 5 |- |}

Serotypes are unknown the following alleles: DRB1*1309, *1315 to *1379 '''DRB1*13''' allele group * 81 Alleles: 74 proteins * '''DR13''' (weak or no DR6) Serotype: *1301, *1302, *1304, *1306, *1307, *1310, *1312 to *1314 * '''DR6''' (weak DR13) Serotype: *1308 * '''DR13'''&Other serotypes: *1303, *1305, *1311, * Serotype unknown: *1309, *1315 to *1374

==Disease associations== '''DRB1*1302''' is linked to early childhood myastenia gravis.<ref name = "EOMGII">{{cite journal |vauthors=Shinomiya N, Nomura Y, Segawa M | title = A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan. | journal = Clin Immunol | volume = 110 | issue = 2 | pages = 154–8 | year = 2004 | pmid = 15003812 | doi = 10.1016/j.clim.2003.10.004}}</ref> Alleles of DR13 along with immunization for hepatitis B and C are most protective against the disease.

===Extended linkage=== '''DRB1*1302:DQA1*0102:DQB1*0604''' Early childhood myastenia gravis<ref name = "EOMGII"/>

==Genetic Linkage== {| id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=left width="300px" |-style="background:#f8f8f8" |align="center" colspan="4" | <div style="font-size:medium; line-height:120%;">DR13 Haplotypes</div> |-style="background:#f8f8f8" | bgcolor="#dddddd"| ! bgcolor="#dddddd"| DRA !! bgcolor="#dddddd"| DRB1 !! bgcolor="#dddddd" | DRB3 |-style="background:#f8f8f8" | rowspan = "3" bgcolor="#e7dcc3" | DR13(6)-DR52 |bgcolor="#eeeeee"| *0101 || bgcolor="#eeeeee"| *1301 || bgcolor="#eeeeee" | *0101 |-style="background:#f8f8f8" |bgcolor="#eeeeee"| *0101 || bgcolor="#eeeeee"| *1301 || bgcolor="#eeeeee" | *0201 |-style="background:#f8f8f8" | bgcolor="#eeeeee"| *0101 || bgcolor="#eeeeee"| *1302 || bgcolor="#eeeeee" | *0301 |-style="background:#f8f8f8" | bgcolor="#dddddd"| ! bgcolor="#dddddd"| DQA1 !! bgcolor="#dddddd"| DQB1 !! bgcolor="#dddddd" | DRB1 |- | bgcolor="#e7dcc3" | DR13(6)-DQ6(6.3, 1) | bgcolor="#eeeeee"| *0103 || bgcolor="#eeeeee"| *0603 || bgcolor="#eeeeee" | *1301 |- | bgcolor="#e7dcc3" | DR13(6)-DQ6(6.4, 1) | bgcolor="#eeeeee"| *0102 || bgcolor="#eeeeee"| *0604 || bgcolor="#eeeeee" | *1302 |-style="background:#f8f8f8" | bgcolor="#e7dcc3" | DR13(6)-DQ6(6.5, 1) | bgcolor="#eeeeee"| *0102 || bgcolor="#eeeeee"| *0605 || bgcolor="#eeeeee" | *1302 |-style="background:#f8f8f8" | bgcolor="#e7dcc3" | DR13(6)-DQ6(6.9, 1) | bgcolor="#eeeeee"| *0102 || bgcolor="#eeeeee"| *0609 || bgcolor="#eeeeee" | *1302 |-style="background:#f8f8f8" | bgcolor="#dddddd"| ! bgcolor="#dddddd"| HLA-A !! bgcolor="#dddddd"| HLA-B !! bgcolor="#dddddd" | DRB1 |- | bgcolor="#e7dcc3" | A2-Cw5-B44(16)-DR13 | bgcolor="#eeeeee"| *02 || bgcolor="#eeeeee"| *4402 || bgcolor="#eeeeee" | *1301 |- |}

HLA-DR13 is genetically linked to DR52<ref name="pmid15041167">{{cite journal |vauthors=Song EY, Park H, Roh EY, Park MH |title=HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans |journal=Hum. Immunol. |volume=65 |issue=3 |pages=270–6 |year=2004 |pmid=15041167 |doi=10.1016/j.humimm.2003.12.005}}</ref> and HLA-DQ6 (HLA-DQ1) serotypes.

==References== {{Reflist}} {{DR serotypes}}

{{DEFAULTSORT:Hla-Dr13}} 6