{| id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="240px" |- | align="center" colspan="2" | 240px|Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen |- | align="center" colspan="2" | <div style="font-size:medium; line-height:120%;">major histocompatibility complex, class II, DR14</div> |- | bgcolor="#e7dcc3" | Haplotypes groups | bgcolor="#eeeeee" | DRA*01:DRB1*1401 DRA*01:DRB1*1402 DRA*01:DRB1*1403 DRA*01:DRB1*1404 .... |- | colspan="2" bgcolor="#dddddd" | '''Structure''' (See HLA-DR) |-style="background:#f8f8f8" | bgcolor="#dddddd" | '''Identifiers'''|| align="center" | <div style="font-size:medium; line-height:120%;">alpha ''*0101''</div> |- | bgcolor="#e7dcc3" | Symbol(s) | bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC4947 HLA-DRA]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }} |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRA*0101 DRA*0101] |-style="background:#f8f8f8" | bgcolor="#dddddd" | '''Identifiers'''|| align="center" | <div style="font-size:medium; line-height:120%;">beta 1 ''*1401'' to ''*1408'' ''*1410''</div> |- | bgcolor="#e7dcc3" | Symbol(s) | bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=4953 HLA-DRB1]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }} |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1401 DRB1*1401] {{Webarchive|url=https://web.archive.org/web/20110515171141/http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1401 |date=2011-05-15 }} |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1402 DRB1*1402] |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1403 DRB1*1403] |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1404 DRB1*1404] |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1405 DRB1*1405] {{Webarchive|url=https://web.archive.org/web/20110515171447/http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1405 |date=2011-05-15 }} |- | bgcolor="#e7dcc3" | EBI-HLA | bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1406 DRB1*1406] |- | colspan="2" bgcolor="#dddddd" | '''Shared data''' |- | bgcolor="#e7dcc3" | Locus | bgcolor="#eeeeee" | chr.6 ''[https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31]'' |- |}
'''HLA-DR14'''(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.
==Alleles== {| border="0" cellspacing="0" cellpadding="0" align="center" style="text-align:center; background:#ffffff; margin-right: 1em; border:2px #e0e0ff solid;" |+ DR14, DR6 and other serotype recognition of some DRB1*14 alleles<ref>[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]</ref> |- style="background:#f0f0ff" | style="width:60px" | DRB1* || style="width:60px" | '''DR14''' | style="width:60px" | DR6 || style="width:60px" | DR13 || style="width:60px" | Sample |- style="background:#f0f0ff" | allele || % || % || % || size (N) |- | style = "background:#e8e8f8" | 1401 || 74 || 14 || 3 || 1942 |- | style = "background:#e8e8f8" | 1402 || 61 || 13 || 9 || 204 |- | style = "background:#e8e8f8" | 1403 || 72 || 12 || 2 || 37 |- | style = "background:#e8e8f8" | 1404 || 79 || 8 || || 80<ref>DR1404 - 3%</ref> |- | style = "background:#e8e8f8" | 1405 || 86 || 10 || || 58 |- | style = "background:#e8e8f8" | 1406 || 37 || 15 || 22 || 117 |- | style = "background:#e8e8f8" | 1407 || 90 || || || 10 |- | style = "background:#e8e8f8" | 1408 || 25 || || || 4 <ref>DR4 - 25%</ref> |- | style = "background:#e8e8f8" | 1410 || >75 || || || 4 |- |}
Serotypes are unknown the following alleles: DRB1**1409, *1419 to *1462
==Disease associations== DRB1*1402: juvenile rheumatoid arthritis,<ref name = "JRA_ColMez">{{cite journal |vauthors=Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D | title = HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos. | journal = Hum Immunol | volume = 65 | issue = 4 | pages = 359–65 | year = 2004 | pmid = 15120191 | doi = 10.1016/j.humimm.2004.01.016}}</ref> increased longevity in Okinawans.
===Extended linkage=== DR*14:DQ5 haplotype: increased risk for non-AChR autoantibodies in myasthenia gravis.<ref name="pmid16769963">{{cite journal |vauthors=Niks EH, Kuks JB, Roep BO, etal | title = Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5 | journal = Neurology | volume = 66 | issue = 11 | pages = 1772–4 | year = 2006 | pmid = 16769963 | doi = 10.1212/01.wnl.0000218159.79769.5c| s2cid = 41206495 }}</ref>
==Genetic Linkage== {| id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=left width="280px" |-style="background:#f8f8f8" |align="center" colspan="4" | <div style="font-size:medium; line-height:120%;">DR14 Haplotypes</div> |-style="background:#f8f8f8" | bgcolor="#dddddd"| ! bgcolor="#dddddd"| DRA !! bgcolor="#dddddd"| DRB1 !! bgcolor="#dddddd" | DRB3 |-style="background:#f8f8f8" | rowspan = "3" bgcolor="#e7dcc3" | DR14(6)-DR52 | bgcolor="#eeeeee"| *0101 || bgcolor="#eeeeee"| *1401 || bgcolor="#eeeeee" | *0201 |-style="background:#f8f8f8" | bgcolor="#eeeeee"| *0101 || bgcolor="#eeeeee"| *1402 || bgcolor="#eeeeee" | *0201 |-style="background:#f8f8f8" | bgcolor="#eeeeee"| *0101 || bgcolor="#eeeeee"| *1403 || bgcolor="#eeeeee" | *0101 |-style="background:#f8f8f8" | bgcolor="#dddddd"| ! bgcolor="#dddddd"| DQA1 !! bgcolor="#dddddd"| DQB1 !! bgcolor="#dddddd" | DRB1 |- | bgcolor="#e7dcc3" | DR14-DQ5(5.3, 1) | bgcolor="#eeeeee"| *0104 || bgcolor="#eeeeee"| *0503 || bgcolor="#eeeeee" | *1401 |-style="background:#f8f8f8" | bgcolor="#dddddd"| ! bgcolor="#dddddd"| HLA-A !! bgcolor="#dddddd"| HLA-B !! bgcolor="#dddddd" | DRB1 |- | bgcolor="#e7dcc3" | A11-B35-DR14(6) | bgcolor="#eeeeee"| *1101 || bgcolor="#eeeeee"| *3501 || bgcolor="#eeeeee" | *1401 |- | bgcolor="#e7dcc3" | A2-B51(5)-DR14(6) | bgcolor="#eeeeee"| *0201 || bgcolor="#eeeeee"| *5101 || bgcolor="#eeeeee" | *1401 |- |}
HLA-DR13 is genetically linked to HLA-DR52<ref name="pmid15041167">{{cite journal |vauthors=Song EY, Park H, Roh EY, Park MH |title=HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans |journal=Hum. Immunol. |volume=65 |issue=3 |pages=270–6 |year=2004 |pmid=15041167 |doi=10.1016/j.humimm.2003.12.005}}</ref> and HLA-DQ5 (HLA-DQ1) serotypes.
==References== {{reflist}} {{DR serotypes}}
{{DEFAULTSORT:Hla-Dr14}} 6