HLA-DQ6

{{Short description|Human leukocyte antigen serotype}} {{cs1 config|name-list-style=vanc}} {{Infobox heteroisoform | isoformgroup = HLA-DQ6 | polymer_type = MHC Class II, DQ cell surface antigen | image = DQ_Illustration.PNG | image_source = Illustration of HLA-DQ with bound peptide | isoformCount = 4 | subunit1 = DQA1 | subunit2 = DQB1 | isoform1 = DQ α1.3β6.1 | nick1 = DQ6.1 | allele1a = {{HQAA|0103}} | allele1b = *0601 | isoform2 = DQ α1.2β6.2 | nick2 = DQ6.2 | allele2a = {{HQAA|0102}} | allele2b = *0602 | isoform3 = DQ α1.3β6.3 | nick3 = DQ6.3 | allele3a = *0103 | allele3b = *0603 | isoform4 = DQ α1.2β6.4 | nick4 = DQ6.4 | allele4a = *0102 | allele4b = *0604 | rareIsoforms = 3 | risoform1 = DQ α1.2β6.3 | rnick1 = DQ6.3v | rallele1a = *0102 | rallele1b = *0603 | risoform2 = DQ α1.3β6.2 | rnick2 = DQ6.2v | rallele2a = *0103 | rallele2b = *0602 | risoform3 = DQ α1.2β6.9 | rnick3 = DQ6.9 | rallele3a = *0102 | rallele3b = *0609 }}

'''HLA-DQ6''' (DQ6) is a human leukocyte antigen serotype within HLA-DQ (DQ) serotype group. The serotype is determined by the antibody recognition of β6 subset of DQ β-chains. The β-chain of DQ isoforms are encoded by HLA-DQB1 locus and DQ6 are encoded by the HLA-DQB1{{color|DarkGreen|*06}} allele group. This group currently contains many common alleles, DQB1{{color|DarkGreen|*0602}} is the most common. '''HLA-DQ6''' and DQB1{{color|DarkGreen|*06}} are almost synonymous in meaning. DQ6 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. For DQ6, however, cis-isoform pairing only occurs with DQ1 α-chains. There are many haplotypes of DQ6.

==Serology== {| border="0" cellspacing="0" cellpadding="0" style="text-align:center; background:#ffffff; margin-right: 1em; border:2px #e0e0ff solid;" |+ DQ6, DQ1, and DQ5 recognition of some Some DQB1* alleles<ref>[http://www.ebi.ac.uk/imgt/hla/allele.html Allele Query Form] IMGT/HLA - European Bioinformatics Institute</ref> |- style="background:#f0f0ff" | style="width:60px" | || style="width:60px" | '''DQ6''' | style="width:60px" | DQ1 || style="width:60px" | '''DQ5''' || style="width:60px" | N |- style="background:#f0f0ff" | allele || % || % || % || size (N) |- | style="background:#e8e8f8" | {{HQBA|0601}} || 64 || 23 || || 675 |- | style="background:#e8e8f8" | {{HQBA|0602}} || 67 || 30 || 1 || 5151 |- | style="background:#e8e8f8" | {{HQBA|0603}} || 62 || 23 || 2 || 2807 |- | style="background:#e8e8f8" | {{HQBA|0604}} || 59 || 27 || 2 || 1592 |- | style="background:#e8e8f8" | {{HQBA|0605}} || 76 || 13 || || 358 |- | style="background:#e8e8f8" | {{HQBA|0609}} || 48 || 32 || 3 || 149 |- |}

==Alleles== {|border="0" cellspacing="0" cellpadding="1" align="right" style="text-align:center; margin-left: 2em; border:1px #ffeebb solid; background:#f8f6f8; " |+ '''HLA DQB1*0601 frequencies''' |- style="background:#efe5ef" | || || freq |- style="background:#eee5ef" | ref. || align="left" |Population || style="width:50px" | (%) |- | <ref name="pmid12753660">{{cite journal |vauthors=Middleton D, Menchaca L, Rood H, Komerofsky R | title= New allele frequency database | journal=Tissue Antigens | issue=5 | pages=403–407 | doi=10.1034/j.1399-0039.2003.00062.x | pmid=12753660 | year=2003 | volume=61 | doi-access=free }}</ref> || align="left"|Indig. Australian Cape York||31.3 |- | || align="left"|Indig. Australian Kimberly||30.5 |- | || align="left"|Nauru||28.4 |- | || align="left"|Fiji Viti Levu||26.3 |- | || align="left"|India Bombay||26.3 |- | || align="left"|Papua New Guinea Lowland||26.0 |- | || align="left"|China Guizhou Prov. Miao||25.9 |- | || align="left"|Papua New Guinea Madang||23.1 |- | || align="left"|Kiribati||22.6 |- | || align="left"|Japan||22.0 |- | || align="left"|Indonesia Nusa Tenggara||19.2 |- | || align="left"|India North Hindus||18.7 |- | || align="left"|Japan Hokkaido Wajin||17.0 |- | || align="left"|Uttar Pradesh Hindu||15.1 |- | || align="left"|PNG Lowland Wosera||14.1 |- | || align="left"|Western Samoa & Tokelau||13.7 |- | || align="left"|Pakistan Kalash||13.0 |- | || align="left"|India Lucknow||12.9 |- | || align="left"|China Wuhan||12.8 |- | || align="left"|South Korea (4)||11.4 |- | || align="left"|PNG Highland||10.9 |- | || align="left"|India Delhi||9.0 |- | || align="left"|Iran Baloch||8.0 |- | || align="left"|Mongolia Khalkha||5.5 |- | || align="left"|Lebanon Yuhmur||4.3 |- | || align="left"|Tunisia Ghannouch||4.3 |- | || align="left"|Poland Wielkopolska||4.0 |- | || align="left"|Mexico Mazatecans||3.5 |- | || align="left"|Spain E. Andalusia||2.0 |- | || align="left"|Italy Central||1.9 |- | || align="left"|France South East||1.6 |- | || align="left"|England Caucasoid||1.1 |- | || align="left"|Ireland South||0.2 |- | || align="left"|Italy Sardinia ||0.1 |- | || align="left"|Brazil Guarani Kaiowa||0.0 |- | || align="left"|Cameroon Saa||0.0 |- |}

===DQB1*0601=== DQB1*0601 is generally linked to DQA1*0103 as 6.1 haplotype. This haplotype is more common in Japan and other parts of East Asia.

{{clear|right}} {|border="0" cellspacing="0" cellpadding="1" align="left" style="text-align:center; margin-right: 2em; border:1px #ffeebb solid; background:#f8f6f8; " |+ '''HLA DQB1*0602 frequencies''' |- style="background:#efe5ef" | || || freq |- style="background:#eee5ef" | ref. || align="left" |Population || style="width:50px" | (%) |- | <ref name="pmid12753660"/> || align="left"|Spain Pas Valley||31.5 |- | || align="left"|Cameroon Saa||30.8 |- | || align="left"|Congo Kinshasa Bantu||30.0 |- | || align="left"|PNG E. Highlands Goroka||29.8 |- | || align="left"|Siberia Ket Lower Yenisey||29.4 |- | || align="left"|Spain North Cabuernigo||28.9 |- | || align="left"|Russia Arkhangelsk Pomors||24.7 |- | || align="left"|Spain North Cantabrian||24.7 |- | || align="left"|Ireland South||19.6 |- | || align="left"|Belgian (2)||19.4 |- | || align="left"|Siberia Kushun Buryat||18.0 |- | || align="left"|Finland||17.1 |- | || align="left"|Siberia Kets Sulamai Village||17.0 |- | || align="left"|Poland Wielkopolska||16.9 |- | || align="left"|German Essen||16.7 |- | || align="left"|Sp. Basque Arratia Valley||16.7 |- | || align="left"|Denmark||16.6 |- | || align="left"|France Ceph||15.7 |- | || align="left"|Kenya ||14.6 |- | || align="left"|England Caucasoid||14.4 |- | || align="left"|Sweden||14.1 |- | || align="left"|France Rennes||13.8 |- | || align="left"|Tunisia Matmata Berber||11.7 |- | || align="left"|Jordan Amman||10.7 |- | || align="left"|Japan Hokkaido Wajin||10.0 |- | || align="left"|Saudi A. Guraiat & Hail||8.4 |- | || align="left"|Japan Central||8.2 |- | || align="left"|Nauru||8.2 |- | || align="left"|Georgia Svaneti Svans||8.1 |- | || align="left"|France South East||8.0 |- | || align="left"|Ethiopia Amhara||7.7 |- | || align="left"|Algeria Oran||7.6 |- | || align="left"|Slovenia||7.5 |- | || align="left"|South Korea (1)||7.4 |- | || align="left"|Japan Fukuoka||6.4 |- | || align="left"|Pakistan Kalash||5.8 |- | || align="left"|China Xinjiang Uygur||5.4 |- | || align="left"|Papua New Guinea Lowland||5.2 |- | || align="left"|Mongolia Khalkh Ulaanbaatar||4.9 |- | || align="left"|Spain Murcia ||4.8 |- | || align="left"|India Bombay||4.2 |- | || align="left"|Japan||4.0 |- | || align="left"|Greece (2)||3.3 |- | || align="left"|Israel Arabs||2.3 |- | || align="left"|Vietnam Hanoi Kinh||2.0 |- | || align="left"|Israel Jews||1.5 |- | || align="left"|Mongolia Khoton Tarialan||1.2 |- | || align="left"|USA Alaska Yupik Natives||0.8 |- | || align="left"|Mexico Mixtec Oaxaca||0.5 |- | || align="left"|Italy Sardinia pop2||0.1 |- |}

{{clear|right}} ===DQB1*0602=== {{Main|HLA DQB1*06:02}} DQB1*0602 is commonly linked to DQA1*0102 to form 6.2 haplotype. DQ6.2 and is common from Central Asia into Western Europe, *0602 is also linked to DQA1*0103 in parts of Asia.

{{clear|left}} {|border="0" cellspacing="0" cellpadding="1" align="right" style="text-align:center; margin-left: 3em; border:1px #ffeebb solid; background:#f8f6f8; " |+ '''HLA DQB1*0603 frequencies''' |- style="background:#efe5ef" | || || freq |- style="background:#eee5ef" | ref. || align="left" |Population || style="width:50px" | (%) |- | <ref name="pmid12753660"/> || align="left"|Georgia Svaneti Svans||14.4 |- | || align="left"|France West||11.0 |- | || align="left"|Netherlands||10.6 |- | || align="left"|German Essen||9.2 |- | || align="left"|Czech Republic||9.0 |- | || align="left"|Spain Murcia ||8.7 |- | || align="left"|Slovakia||8.4 |- | || align="left"|Denmark||8.3 |- | || align="left"|India Lucknow||8.3 |- | || align="left"|Jordan Amman||8.3 |- | || align="left"|France Rennes||8.1 |- | || align="left"|Poland Wielkopolska||8.0 |- | || align="left"|Saudi Arabia Guraiat & Hail||8.0 |- | || align="left"|Tunisia Jerba Berber||7.8 |- | || align="left"|Uganda Muganda Baganda||7.4 |- | || align="left"|Spain North Cantabrian||7.2 |- | || align="left"|Finland||7.1 |- | || align="left"|France South||6.9 |- | || align="left"|China Xinjiang Uygur||6.5 |- | || align="left"|Russia Northwest Slavic||6.0 |- | || align="left"|Ireland Donegal||5.3 |- | || align="left"|Greece (3)||5.2 |- | || align="left"|Ireland Northern (2)||4.9 |- | || align="left"|Italy Rome||4.0 |- | || align="left"|CAR Aka Pygmies||3.6 |- | || align="left"|Lebanon Kafar Zubian||3.2 |- | || align="left"|Sweden||2.5 |- | || align="left"|Thailand||2.1 |- | || align="left"|China Wuhan||1.7 |- | || align="left"|Japan (2)||1.0 |- | || align="left"|South Korea (3)||0.9 |- | || align="left"|Malaysia||0.6 |- |}

{{clear|left}} ===DQB1*0603=== DQB1*0603 is commonly linked to DQA1*0103 as 6.3 and is common from Central Asia into Western Europe, *0603 is also linked to DQA1*0102 in parts of Asia. In Europe it is most common in the Netherlands.

{{clear|right}} ===DQB1*0604=== DQB1*0604 is found at higher frequencies in parts Africa and Asia and is linked almost exclusively to DQA1*0102 as 6.4. This haplotype is found at its highest Eurasian frequencies in Japan.

{{clear|left}} {|border="0" cellspacing="0" cellpadding="1" align="right" style="text-align:center; margin-left: 2em; border:1px #ffeebb solid; background:#f8f6f8; " |+ '''HLA DQB1*0609 frequencies''' |- style="background:#efe5ef" | || || freq |- style="background:#eee5ef" | ref. || align="left" |Population || style="width:50px" | (%) |- | <ref name="pmid12753660"/> || align="left"|Rwanda Kigali Hutu & Tutsi||5.7 |- | || align="left"|Kenya ||5.3 |- | || align="left"|Uganda Muganda Baganda||5.3 |- | || align="left"|Congo Kinshasa Bantu||4.4 |- | || align="left"|Gambia||4.4 |- | || align="left"|Mongolia Tsaatan||4.2 |- | || align="left"|South Korea (3)||3.7 |- | || align="left"|Cameroon Saa||3.5 |- | || align="left"|Slovenia||3.0 |- | || align="left"|Tunisia||3.0 |- | || align="left"|Zimbabwe Harare Shona||2.2 |- | || align="left"|Vietnam Hanoi Kinh||2.0 |- | || align="left"|Netherlands||1.7 |- | || align="left"|Saudi Arabia Guraiat & Hail||1.6 |- | || align="left"|Algeria Oran||1.5 |- | || align="left"|Greece (2)||1.2 |- | || align="left"|Thailand (2)||1.2 |- | || align="left"|Tunisia Matmata Berber||1.2 |- | || align="left"|Italy Rome||1.0 |- | || align="left"|Spain Granada||0.7 |- | || align="left"|Italy Bergamo||0.6 |- | || align="left"|Ireland South||0.2 |- | || align="left"|China Ürümqi Uygur||0.0 |- | || align="left"|USA Alaska Yupik Natives||0.0 |- |}

{{clear|left}} ===DQB1*0609=== DQB1*0609 is found in Africa and proximal regions of Eurasia.

==Haplotypes and disease== Susceptibility to ''Leptospirosis'' infection was found associated with undifferentiated DQ6.<ref name="pmid15014429">{{cite journal |author=Lingappa J |title=HLA-DQ6 and ingestion of contaminated water: possible gene-environment interaction in an outbreak of Leptospirosis |journal=Genes Immun. |volume=5 |issue=3 |pages=197–202 |date=May 2004 |pmid=15014429 |doi=10.1038/sj.gene.6364058 |author2=Kuffner T |author3=Tappero J |last4=Whitworth |first4=W |last5=Mize |first5=A |last6=Kaiser |first6=R |last7=McNicholl |first7=J|s2cid=1771348 |doi-access= }}</ref> Whereas DQ6 was protective against death (or need for liver transplantion) in primary sclerosing cholangitis.<ref name="pmid11495087">{{cite journal |author=Boberg KM |title=The HLA-DR3,DQ2 heterozygous genotype is associated with an accelerated progression of primary sclerosing cholangitis |journal=Scand. J. Gastroenterol. |volume=36 |issue=8 |pages=886–890 |date=August 2001 |pmid=11495087 |doi= 10.1080/003655201750313441|author2=Spurkland A |author3=Rocca G |last4=Egeland |first4=T. |last5=Saarinen |first5=S. |last6=Mitchell |first6=S. |last7=Broomé |first7=U. |last8=Chapman |first8=R. |last9=Olerup |first9=O.}}</ref>

===DQ6.1=== '''DQA1*0103:DQB1*0601''' (DQ6.1) is found at increased frequencies in Asia and is almost absent in Western Europe. It confers protection from narcolepsy,<ref name="pmid17207713">{{cite journal | author = Hong SC | title = DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans | journal = Hum. Immunol. | volume = 68 | issue = 1 | pages = 59–68 | year = 2007 | pmid = 17207713 | doi = 10.1016/j.humimm.2006.10.006 | author2 = Lin L | author3 = Lo B | last4 = Jeong | first4 = J | last5 = Shin | first5 = Y | last6 = Kim | first6 = S | last7 = Kweon | first7 = Y | last8 = Zhang | first8 = J | last9 = Einen | first9 = M}}</ref> juvenile diabetes,<ref name="pmid11780465">{{cite journal |vauthors=Sang Y, Yan C, Zhu C, Ni G | title = Relationship between HLA-DRB1 and DQ alleles and the genetic susceptibility to type 1 diabetes | journal = Chin. Med. J. | volume = 114 | issue = 4 | pages = 407–9 | year = 2001 | pmid = 11780465 }}</ref><ref name="pmid10689119">{{cite journal | author = Saruhan-Direskeneli G | title = HLA-DR and -DQ associations with insulin-dependent diabetes mellitus in a population of Turkey | journal = Hum. Immunol. | volume = 61 | issue = 3 | pages = 296–302 | year = 2000 | pmid = 10689119 | doi =10.1016/S0198-8859(99)00182-2 | author2 = Uyar FA | author3 = Bas F | last4 = Günöz | first4 = H | last5 = Bundak | first5 = R | last6 = Saka | first6 = N | last7 = Darendeliler | first7 = F }}</ref> Vogt-Koyanagi-Harada (VKH) syndrome,<ref name="pmid10682969">{{cite journal | author = Kim MH | title = Association of HLA with Vogt-Koyanagi-Harada syndrome in Koreans | journal = Am. J. Ophthalmol. | volume = 129 | issue = 2 | pages = 173–177 | year = 2000 | pmid = 10682969 | doi =10.1016/S0002-9394(99)00434-1 | author2 = Seong MC | author3 = Kwak NH | last4 = Yoo | first4 = Jin-Seong | last5 = Huh | first5 = Warne | last6 = Kim | first6 = Tai-Gyu | last7 = Han | first7 = Hoon }}</ref> pemphigus vulgaris,<ref name="pmid7871526">{{cite journal | author = Niizeki H | title = HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method | journal = Tissue Antigens | volume = 44 | issue = 4 | pages = 248–251 | year = 1994 | pmid = 7871526 | doi =10.1111/j.1399-0039.1994.tb02390.x | author2 = Inoko H | author3 = Mizuki N | last4 = Inamoto | first4 = Nobuko | last5 = Watababe | first5 = Kyoko | last6 = Hashimoto | first6 = Takashi | last7 = Nishikawa | first7 = Takeji }}</ref> multiple sclerosis,<ref name="pmid9777330">{{cite journal | author = Amirzargar A | title = HLA class II (DRB1, DQA1 and DQB1) associated genetic susceptibility in Iranian multiple sclerosis (MS) patients | journal = Eur. J. Immunogenet. | volume = 25 | issue = 4 | pages = 297–301 | year = 1998 | pmid = 9777330 | doi =10.1046/j.1365-2370.1998.00101.x | author2 = Mytilineos J | author3 = Yousefipour A | last4 = Farjadian | first4 = Sh. | last5 = Scherer | first5 = S. | last6 = Opelz | first6 = G. | last7 = Ghaderi | first7 = A. | doi-access = free }}</ref> myasthenia gravis.

===DQ6.2=== DQ6.2 (DQA1{{color|DarkOrchid|*0102}} : DQB1{{color|DarkGreen|*0602}}) is commonly linked to DR15 and as such is part of the HLA B7-DR15-DQ6 haplotype. This haplotype is considered to be the longest multigene haplotype known within the human genome as it covers over 4.7 million nucleotides. The DR15-DQ6.2 haplotype is the most common DR-DQ haplotype in Europe, and approximately 30% of Americans carry at least DQ6.2. The haplotype is even more common in Central Asia.

====DQ6.2 associations with disease==== For ''myasthenia gravis'', recognition α34-49 of AChR increased with DQ6.2.<ref name="pmid16891216">{{cite journal |vauthors=Deitiker PR, Oshima M, Smith RG, Mosier DR, Atassi MZ | title = Subtle differences in HLA DQ haplotype-associated presentation of AChR alpha-chain peptides may suffice to mediate myasthenia gravis | journal = Autoimmunity | volume = 39 | issue = 4 | pages = 277–288 | year = 2006 | pmid = 16891216 | doi = 10.1080/08916930600738581| s2cid = 23462117 }}</ref> DQA1{{color|DarkOrchid|*0102}} increases risk cervical cancer.<ref name="pmid11045789">{{cite journal |author=Ghaderi M |title=Tumor necrosis factor a-11 and DR15-DQ6 (B*0602) haplotype increase the risk for cervical intraepithelial neoplasia in human papillomavirus 16 seropositive women in Northern Sweden |journal=Cancer Epidemiol. Biomarkers Prev. |volume=9 |issue=10 |pages=1067–70 |date=October 2000 |pmid=11045789 |url=http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=11045789 |author2=Nikitina L |author3=Peacock CS |last4=Hjelmström |first4=P |last5=Hallmans |first5=G |last6=Wiklund |first6=F |last7=Lenner |first7=P |last8=Blackwell |first8=JM |last9=Dillner |first9=J}}</ref><ref name="pmid16386646">{{cite journal |vauthors=Schiff MA, Apple RJ, Lin P, Nelson JL, Wheeler CM, Becker TM | title = HLA alleles and risk of cervical intraepithelial neoplasia among southwestern American Indian women | journal = Hum. Immunol. | volume = 66 | issue = 10 | pages = 1050–1056 | year = 2005 | pmid = 16386646 | doi = 10.1016/j.humimm.2005.09.002}}</ref> In multiple sclerosis DQA1{{color|DarkOrchid|*0102}} was the most frequent allele and DQB1{{color|DarkGreen|*0602}} increased significantly in the MS patients.<ref name="pmid2477915">{{cite journal |vauthors=Kolstad A, Hannestad K, Vandvik B, Vartdal F |title=Multiple sclerosis patients have a high frequency of an HLA-DQ beta epitope defined by a human-human hybridoma antibody |journal=Tissue Antigens |volume=33 |issue=5 |pages=546–549 |date=May 1989 |pmid=2477915 |doi= 10.1111/j.1399-0039.1989.tb01706.x}}</ref><ref name="pmid15613143">{{cite journal | author = Amirzargar AA | title = Optic neuritis, multiple sclerosis and human leukocyte antigen: results of a 4-year follow-up study | journal = Eur. J. Neurol. | volume = 12 | issue = 1 | pages = 25–30 | year = 2005 | pmid = 15613143 | doi = 10.1111/j.1468-1331.2004.00901.x | author2 = Tabasi A | author3 = Khosravi F | last4 = Kheradvar | first4 = A. | last5 = Rezaei | first5 = N. | last6 = Naroueynejad | first6 = M. | last7 = Ansaripour | first7 = B. | last8 = Moradi | first8 = B. | last9 = Nikbin | first9 = B.| s2cid = 11114806 }}</ref><ref name="pmid15083289">{{cite journal|author=Fernández O|author2=Fernández V|author3=Alonso A|last4=Caballero|first4=A.|last5=Luque|first5=G.|last6=Bravo|first6=M.|last7=León|first7=A.|last8=Mayorga|first8=C.|last9=Leyva|first9=L.|year=2004|title=DQB1*0602 allele shows a strong association with multiple sclerosis in patients in Malaga, Spain|journal=J. Neurol.|volume=251|issue=4|pages=440–444|doi=10.1007/s00415-004-0350-2|pmid=15083289|s2cid=6388921 |hdl=10630/32581|hdl-access=free}}</ref>

====Protective effects of DQ6.2==== In ''primary biliary cirrhosis'' DQ6.2 appears to have a negative association with disease.<ref name="pmid15713222">{{cite journal | author = Mullarkey ME | title = Human leukocyte antigen class II alleles in Caucasian women with primary biliary cirrhosis | journal = Tissue Antigens | volume = 65 | issue = 2 | pages = 199–205 | year = 2005 | pmid = 15713222 | doi = 10.1111/j.1399-0039.2005.00351.x | author2 = Stevens AM | author3 = McDonnell WM | last4 = Loubiere | first4 = L.S. | last5 = Brackensick | first5 = J.A. | last6 = Pang | first6 = J.M. | last7 = Porter | first7 = A.J. | last8 = Galloway | first8 = D.A. | last9 = Nelson | first9 = J.L.}}</ref> DQ6.2 also appears to have a protective effect in juvenile diabetes.<ref name="pmid12071438">{{cite journal |vauthors=Rayner ML, Kelly MA, Mijovic CH, Barnett AH |title=Sequencing of the second exon of the MHC class II DQ6 alleles in patients with type 1 diabetes |journal=Autoimmunity |volume=35 |issue=2 |pages=155–157 |date=March 2002 |pmid=12071438 |doi= 10.1080/08916930290016637|s2cid=46348916 }}</ref><ref name="pmid12140742">{{cite journal |vauthors=Pociot F, McDermott MF |title=Genetics of type 1 diabetes mellitus |journal=Genes Immun. |volume=3 |issue=5 |pages=235–249 |date=August 2002 |pmid=12140742 |doi=10.1038/sj.gene.6363875 |s2cid=19983853 |doi-access= }}</ref> DQ6.2 is also protective against infantile spasms in mestizos.<ref name="pmid11240591">{{cite journal |vauthors=Suastegui RA, De La Rosa G, Carranza JM, Gonzalez-Astiazaran A, Gorodezky C |title=Contribution of the MHC class II antigens to the etiology of infantile spasm in Mexican Mestizos |journal=Epilepsia |volume=42 |issue=2 |pages=210–215 |date=February 2001 |pmid=11240591 |doi=10.1046/j.1528-1157.2001.22700.x |doi-access=free }}</ref>

===DQ6.3=== DQ6.3 (DQA1{{color|DarkOrchid|*0103}} : DQB1{{color|DarkGreen|*0603}}) is found in northcentral Europe at moderate frequencies, it is a protective against many autoimmune diseases. It also affords some protection to HIV infection.<ref name="pmid9031330">{{cite journal |vauthors=Achord AP, Lewis RE, Brackin MN, Henderson H, Cruse JM |title=HIV-1 disease association with HLA-DQ antigens in African Americans and Caucasians |journal=Pathobiology |volume=64 |issue=4 |pages=204–208 |year=1996 |pmid=9031330 |doi= 10.1159/000164049}}</ref>

===DQ6.4=== DQ6.4 (DQA1{{color|DarkOrchid|*0102}} : DQB1{{color|DarkGreen|*0604}}) might be associated with thymoma-induced myasthenia gravis.<ref>{{cite journal |vauthors=Vieira M, Caillat-Zucman S, Gajdos P, Cohen-Kaminsky S, Casteur A, Bach J | title = Identification by genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis | journal = J Neuroimmunol | volume = 47 | issue = 2 | pages = 115–122 | year = 1993 | pmid = 8370765 | doi = 10.1016/0165-5728(93)90021-P| s2cid = 3771373 }}</ref>

==References== {{Reflist|2}} {{DQ serotypes}}

{{DEFAULTSORT:Hla-Dq6}} 6

HLA-DQ6

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