{{Short description|Protein}} {{cs1 config|name-list-style=vanc}} {{protein |Name=cyclin E2 |caption= |image= |width= |HGNCid=1590 |Symbol=CCNE2 |AltSymbols= |EntrezGene=9134 |OMIM=603775 |RefSeq=NM_057749 |UniProt=O96020 |PDB= |ECnumber= |Chromosome=8 |Arm=q |Band=22.1 |LocusSupplementaryData= }}
'''Cyclin E2''' is a protein that in humans is encoded by the ''CCNE2'' gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1).<ref name=pmid9858585>{{cite journal | vauthors = Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S | title = Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers | journal = Molecular and Cellular Biology | volume = 19 | issue = 1 | pages = 612–22 | date = January 1999 | pmid = 9858585 | pmc = 83919 | doi = 10.1128/mcb.19.1.612 }}</ref> It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.<ref name=pmid9858585/>
== References == {{reflist}} * {{Cite journal |last1=Zariwala |first1=M. |last2=Liu |first2=J. |last3=Xiong |first3=Y. |date=1998-11-26 |title=Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins |journal=Oncogene |volume=17 |issue=21 |pages=2787–2798 |doi=10.1038/sj.onc.1202505 |issn=0950-9232 |pmid=9840943|s2cid=7340570 |doi-access=free }}
{{Cell_cycle_proteins}}
Category:Proteins