Cyclin-dependent kinase 3

{{cs1 config|name-list-style=vanc}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Redirect|CDK3|the IATA airport code|Dorset/Kawagama Lake (South) Water Aerodrome}} {{Infobox_gene}} '''Cell division protein kinase 3''' is an enzyme that in humans is encoded by the ''CDK3'' gene.<ref name="pmid1639063">{{cite journal | vauthors = Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH | title = A family of human cdc2-related protein kinases | journal = EMBO J | volume = 11 | issue = 8 | pages = 2909–17 |date=Aug 1992 | pmid = 1639063 | pmc = 556772 | doi = 10.1002/j.1460-2075.1992.tb05360.x}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDK3 cyclin-dependent kinase 3| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1018}}</ref>

== Function ==

CDK3 complements cdc28 mutants of ''Saccharomyces cerevisiae'' suggesting that it may be involved in cell cycle control. CDK3 can phosphorylate histone H1 and interacts with an unknown type of cyclin.<ref name="entrez"/>

==References== {{reflist}}

==Further reading== {{refbegin|35em}} *{{cite journal | vauthors=Bullrich F, MacLachlan TK, Sang N |title=Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. |journal=Cancer Res. |volume=55 |issue= 6 |pages= 1199–205 |year= 1995 |pmid= 7882308 |display-authors=etal}} *{{cite journal | vauthors=Gyuris J, Golemis E, Chertkov H, Brent R |title=Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. |journal=Cell |volume=75 |issue= 4 |pages= 791–803 |year= 1993 |pmid= 8242750 |doi=10.1016/0092-8674(93)90498-F |doi-access=free }} *{{cite journal | vauthors=Sasaguri T, Ishida A, Kosaka C |title=Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells. |journal=J. Biol. Chem. |volume=271 |issue= 14 |pages= 8345–51 |year= 1996 |pmid= 8626531 |doi=10.1074/jbc.271.14.8345 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Meikrantz W, Schlegel R |title=Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10205–9 |year= 1996 |pmid= 8626584 |doi=10.1074/jbc.271.17.10205 |doi-access=free }} *{{cite journal | vauthors=Hofmann F, Livingston DM |title=Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. |journal=Genes Dev. |volume=10 |issue= 7 |pages= 851–61 |year= 1996 |pmid= 8846921 |doi=10.1101/gad.10.7.851 |doi-access=free }} *{{cite journal | vauthors=Lamphere L, Fiore F, Xu X |title=Interaction between Cdc37 and Cdk4 in human cells. |journal=Oncogene |volume=14 |issue= 16 |pages= 1999–2004 |year= 1997 |pmid= 9150368 |doi= 10.1038/sj.onc.1201036 |s2cid=25236893 |display-authors=etal|doi-access= }} *{{cite journal | vauthors=Braun K, Hölzl G, Soucek T |title=Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. |journal=Oncogene |volume=17 |issue= 17 |pages= 2259–69 |year= 1998 |pmid= 9811456 |doi= 10.1038/sj.onc.1202145 |s2cid=12470182 |display-authors=etal|doi-access= }} *{{cite journal | vauthors=Yamochi T, Semba K, Tsuji K |title=ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). |journal=Eur. J. Biochem. |volume=268 |issue= 23 |pages= 6076–82 |year= 2002 |pmid= 11733001 |doi=10.1046/j.0014-2956.2001.02555.x |display-authors=etal}} *{{cite journal | vauthors=Sato H, Nishimoto I, Matsuoka M |title=ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl. |journal=Biochim. Biophys. Acta |volume=1574 |issue= 2 |pages= 157–63 |year= 2002 |pmid= 11955625 |doi=10.1016/S0167-4781(01)00367-0 }} *{{cite journal | vauthors=Schang LM, Bantly A, Schaffer PA |title=Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4 |journal=J. Virol. |volume=76 |issue= 15 |pages= 7724–35 |year= 2002 |pmid= 12097586 |doi=10.1128/JVI.76.15.7724-7735.2002 | pmc=136347 }} *{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Ren S, Rollins BJ |title=Cyclin C/cdk3 promotes Rb-dependent G0 exit |journal=Cell |volume=117 |issue= 2 |pages= 239–51 |year= 2004 |pmid= 15084261 |doi=10.1016/S0092-8674(04)00300-9 |s2cid=890866 |doi-access=free }} *{{cite journal | vauthors=Zhang Y, Wolf-Yadlin A, Ross PL |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules |journal=Mol. Cell. Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 |display-authors=etal}} *{{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Wissing J, Jänsch L, Nimtz M |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry |journal=Mol. Cell. Proteomics |volume=6 |issue= 3 |pages= 537–47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200 |s2cid=40974821 |display-authors=etal|url=https://hzi.openrepository.com/bitstream/10033/19756/1/Wissing%20et%20al_final.pdf |doi-access=free }} {{refend}}

==External links== * {{MeshName|CDK3+protein,+human}} * {{UCSC genome browser|CDK3}} * {{UCSC gene details|CDK3}}

{{DEFAULTSORT:Cyclin-dependent kinase 03}} Category:Cell cycle Category:Proteins Category:EC 2.7.11