Transporter Classification Database

{{Short description|Classification of membrane proteins including ion channels}} The '''Transporter Classification Database''' (or '''TCDB''') is an International Union of Biochemistry and Molecular Biology (IUBMB)-approved classification system for membrane transport proteins, including ion channels.<ref>{{cite journal|last1=Saier|first1=Milton H.|last2=Reddy|first2=Vamsee S.|last3=Tamang|first3=Dorjee G.|last4=Västermark|first4=Åke|title=The Transporter Classification Database|journal=Nucleic Acids Research|date=January 2014|volume=42|issue=D1|pages=D251–D258|doi=10.1093/nar/gkt1097|pmid=24225317|url= |pmc=3964967}}</ref><ref>{{cite journal|last1=Saier|first1=M. H.|last2=Yen|first2=M. R.|last3=Noto|first3=K.|last4=Tamang|first4=D. G.|last5=Elkan|first5=C.|title=The Transporter Classification Database: recent advances|journal=Nucleic Acids Research|date=1 January 2009|volume=37|issue=Database|pages=D274–D278|doi=10.1093/nar/gkn862|url= |pmid=19022853|pmc=2686586}}</ref><ref>{{cite journal|last1=Saier|first1=M. H.|last2=Tran|first2=C. V.|last3=Barabote|first3=R. D.|title=TCDB: the Transporter Classification Database for membrane transport protein analyses and information|journal=Nucleic Acids Research|date=1 January 2006|volume=34|issue=90001|pages=D181–D186|doi=10.1093/nar/gkj001|url= |pmid=16381841|pmc=1334385}}</ref>

==Classification== The upper level of classification and a few examples of proteins with known 3D structure:

===1. Channels and pores===

====1.A α-type channels==== * 1.A.1 Voltage-gated ion channel superfamily * 1.A.2 Inward-rectifier K⁺ channel family * 1.A.3 Ryanodine-inositol-1,4,5-trisphosphate receptor Ca²⁺ channel family * 1.A.4 Transient receptor potential Ca²⁺ channel family * 1.A.5 Polycystin cation channel family * 1.A.6 Epithelial Na⁺ channel family * 1.A.7 ATP-gated P2X receptor cation channel family * 1.A.8 Major intrinsic protein superfamily * 1.A.9 Neurotransmitter receptor, Cys loop, ligand-gated ion channel family * 1.A.10 Glutamate-gated ion channel family of neurotransmitter receptors * 1.A.11 Ammonium channel transporter family * 1.A.12 Intracellular chloride channel family * 1.A.13 Epithelial chloride channel family * 1.A.14 Testis-enhanced gene transfer family * 1.A.15 Nonselective cation channel-2 family * 1.A.16 Formate-nitrite transporter family * 1.A.17 Calcium-dependent chloride channel family * 1.A.18 Chloroplast envelope anion-channel-forming Tic110 family * 1.A.19 Type A influenza virus matrix-2 channel family * 1.A.20 BCL2/Adenovirus E1B-interacting protein 3 family * 1.A.21 Bcl-2 family * 1.A.22 Large-conductance mechanosensitive ion channel * 1.A.23 Small-conductance mechanosensitive ion channel * 1.A.24 Gap-junction-forming connexin family * 1.A.25 Gap-junction-forming innexin family * 1.A.26 Mg²⁺ transporter-E family * 1.A.27 Phospholemman family * 1.A.28 Urea transporter family * 1.A.29 Urea/amide channel family * 1.A.30 H⁺- or Na⁺-translocating bacterial MotAB flagellar motor/ExbBD outer-membrane transport energizer superfamily * 1.A.31 Annexin family * 1.A.32 Type B influenza virus NB channel family * 1.A.33 Cation-channel-forming heat shock protein 70 family * 1.A.34 ''Bacillus'' gap junction-like channel-forming complex family * 1.A.35 CorA metal ion transporter family * 1.A.36 Intracellular chloride channel family * 1.A.37 CD20 Ca²⁺ channel family * 1.A.38 Golgi pH regulator family * 1.A.39 Type C influenza virus CM2 channel family * 1.A.40 Human immunodeficiency virus type I Vpu channel family * 1.A.41 Avian reovirus p10 Vvroporin family * 1.A.42 HIV viral protein R family * 1.A.43 Camphor resistance or fluoride exporter family * 1.A.44 Pore-forming tail Tip pb2 protein of phage T5 family * 1.A.45 Phage P22 injectisome family * 1.A.46 Anion channel-forming bestrophin family * 1.A.47 Nucleotide-sensitive anion-selective channel, ICln family * 1.A.48 Anion channel Tweety family * 1.A.49 Human coronavirus ns12.9 viroporin family * 1.A.50 Phospholamban (Ca²⁺-channel and Ca²⁺-ATPase regulator) family *1.A.51 The Voltage-gated Proton Channel (VPC) Family *1.A.52 The Ca²⁺ Release-activated Ca²⁺ (CRAC) Channel (CRAC-C) Family *1.A.53 The Hepatitis C Virus P7 Viroporin Cation-selective Channel (HCV-P7) Family *1.A.54 The Presenilin ER Ca²⁺ Leak Channel (Presenilin) Family *1.A.55 The Synaptic Vesicle-Associated Ca²⁺ Channel, Flower (Flower) Family *1.A.56 The Copper Transporter (Ctr) Family *1.A.57 The Human SARS Coronavirus Viroporin (SARS-VP) *1.A.58 The Type B Influenza Virus Matrix Protein 2 (BM2-C) Family *1.A.59 The Bursal Disease Virus Pore-Forming Peptide, Pep46 (Pep46) Family *1.A.60 The Mammalian Reovirus Pre-forming Peptide, Mu-1 (Mu-1) Family *1.A.61 The Insect Nodavirus Channel-forming Chain F (Gamma-Peptide) Family *1.A.62 The Homotrimeric Cation Channel (TRIC) Family *1.A.63 The Ignicoccus Outer Membrane α-helical Porin (I-OMP Family *1.A.64 The Plasmolipin (Plasmolipin) Family *1.A.65 The Coronavirus Viroporin E Protein (Viroporin E) Family *1.A.66 The Pardaxin (Pardaxin) Family *1.A.67 The Membrane Mg²⁺ Transporter (MMgT) Family *1.A.68 The Viral Small Hydrophobic Viroporin (V-SH) Family *1.A.69 The Heteromeric Odorant Receptor Channel (HORC) Family *1.A.70 The Molecule Against Microbes A (MamA) Family *1.A.71 The Brain Acid-soluble Protein Channel (BASP1 Channel) Family *1.A.72 The Mer Superfamily *1.A.73 The Colicin Lysis Protein (CLP) Family *1.A.74 The Mitsugumin 23 (MG23) Family *1.A.75 The Mechanical Nociceptor, Piezo (Piezo) Family *1.A.76 The Magnesium Transporter1 (MagT1) Family *1.A.77 The Mg²⁺/Ca²⁺ Uniporter (MCU) Family *1.A.78 The K⁺-selective Channel in Endosomes and Lysosomes (KEL) Family *1.A.79 The Cholesterol Uptake Protein (ChUP) or Double Stranded RNA Uptake Family *1.A.80 The NS4a Viroporin (NS4a) Family *1.A.81 The Low Affinity Ca²⁺ Channel (LACC) Family *1.A.82 The Hair Cell Mechanotransduction Channel (HCMC) Family *1.A.83 The SV40 Virus Viroporin VP2 (SV40 VP2) Family *1.A.84 The Calcium Homeostasis Modulator Ca²⁺ Channel (CALHM-C) Family *1.A.85 The Poliovirus 2B Viroporin (2B Viroporin) Family *1.A.86 The Human Papilloma Virus type 16 (HPV16) L2 Viroporin (L2 Viroporin) Family *1.A.87 The Mechanosensitive Calcium Channel (MCA) Family *1.A.88 The Fungal Potassium Channel (F-Kch) Family *1.A.89 The Human Coronavirus 229E Viroporin (229E Viroporin) Family *1.A.90 The Human Metapneumovirus (HMPV) Viroporin (HMPV-Viroporin) Family *1.A.91 The Cytoadherence-linked Asexual Protein 3.2 of Plasmodium falciparum (Clag3) Family *1.A.92 The Reovirus Viroporin VP10 (RVP10) Family *1.A.93 The Bluetongue Virus Non-Structural Protein 3 Viroporin (NS3) Family *1.A.94 The Rotavirus Non-structural Glycoprotein 4 Viroporin (NSP4) Family *1.A.95 The Ephemerovirus Viroporin (EVVP) Family *1.A.96 The Human Polyoma Virus Viroporin (PVVP) Family *1.A.97 The Human Papillomavirus type 16 E5 Viroporin (HPV-E5) Family *1.A.98 Human T-Lymphotropic Virus 1 P13 protein (HTLV1-P13) Family *1.A.99 The Infectious Bronchitis Virus Envelope Small Membrane Protein E (IBV-E) Family *1.A.100 The Rhabdoviridae Putative Viroporin, U5 (RV-U5) Family *1.A.101 The Peroxisomal Pore-forming Pex11 (Pex11) Family *1.A.102 Influenza A viroporin PB1-F2 (PB1-F2) Family *1.A.103 The Simian Virus 5 (Parainfluenza Virus 5) SH (SV5-SH) Family *1.A.104 The Proposed Flagellar Biosynthesis Na⁺ Channel, FlaH (FlaH) Family *1.A.105 The Mixed Lineage Kinase Domain-like (MLKL) Family *1.A.106 The Calcium Load-activated Calcium Channel (CLAC) Family *1.A.107 The Pore-forming Globin (Globin) Family

====1.B. β-Barrel porins and other outer membrane proteins==== * 1.B.1 General bacterial porin family * 1.B.2 Chlamydial porin (CP) family * 1.B.3 Sugar porin (SP) family * 1.B.4 Brucella-Rhizobium porin (BRP) family * 1.B.5 Pseudomonas OprP porin (POP) family * 1.B.6 OmpA-OmpF porin (OOP) family * 1.B.7 Rhodobacter PorCa porin (RPP) family * 1.B.8 Mitochondrial and plastid porin (MPP) family * 1.B.9 FadL outer membrane protein (FadL) family * 1.B.10 Nucleoside-specific channel-forming outer membrane porin (Tsx) family * 1.B.11 Outer membrane fimbrial usher porin (FUP) family * 1.B.12 Autotransporter-1 (AT-1) family * 1.B.13 Alginate export porin (AEP) family * 1.B.14 Outer membrane receptor (OMR) family * 1.B.15 Raffinose porin (RafY) family * 1.B.16 Short chain amide and urea porin (SAP) family * 1.B.17 Outer membrane factor (OMF) family * 1.B.18 Outer membrane auxiliary (OMA) protein family * 1.B.19 Glucose-selective OprB porin (OprB) family * 1.B.20 Two-partner secretion (TPS) family * 1.B.21 OmpG porin (OmpG) family * 1.B.22 Outer bacterial membrane secretin (secretin) family * 1.B.23 Cyanobacterial porin (CBP) family * 1.B.24 Mycobacterial porin * 1.B.25 Outer membrane porin (Opr) family * 1.B.26 Cyclodextrin porin (CDP) family * 1.B.31 Campylobacter jejuni major outer membrane porin (MomP) family * 1.B.32 Fusobacterial outer membrane porin (FomP) family * 1.B.33 Outer membrane protein insertion porin (Bam complex) (OmpIP) family * 1.B.34 Corynebacterial porins * 1.B.35 Oligogalacturonate-specific porin (KdgM) family * 1.B.39 Bacterial porin, OmpW (OmpW) family * 1.B.42 Outer membrane lipopolysaccharide export porin (LPS-EP) family * 1.B.43 Coxiella porin P1 (CPP1) family * 1.B.44 Probable protein translocating porphyromonas gingivalis porin (PorT) family * 1.B.49 Anaplasma P44 (A-P44) porin family * 1.B.48 Curli-like transporters * 1.B.54 Intimin/Invasin (Int/Inv) or Autotransporter-3 family * 1.B.55 Poly-acetyl-D-glucosamine porin (PgaA) family * 1.B.57 Legionella major-outer membrane protein (LM-OMP) family * 1.B.60 Omp50 porin (Omp50 Porin) family * 1.B.61 Delta-proteobacterial porin (Delta-porin) family * 1.B.62 Putative bacterial porin (PBP) family * 1.B.66 Putative beta-barrel porin-2 (BBP2) family * 1.B.67 Putative beta barrel porin-4 (BBP4) family * 1.B.68 Putative beta barrel porin-5 (BBP5) superfamily * 1.B.70 Outer membrane channel (OMC) family * 1.B.71 Proteobacterial/verrucomicrobial porin (PVP) family * 1.B.72 Protochlamydial outer membrane porin (PomS/T) family * 1.B.73 Capsule biogenesis/assembly (CBA) family * 1.B.78 DUF3374 electron transport-associated porin (ETPorin) family

====1.C Pore-forming toxins (proteins and peptides)==== * 1.C.3 α-Hemolysin (αHL) family * 1.C.4 Aerolysin family * 1.C.5 ε-toxin family * 1.C.11 RTX-toxin superfamily * 1.C.12 Membrane attack complex/perforin superfamily * 1.C.13 Leukocidin family * 1.C.14 Cytohemolysin (CHL) family * 1.C.39 Thiol-activated cholesterol-dependent cytolysin family * 1.C.43 Lysenin family * 1.C.56 ''Pseudomonas syringae'' HrpZ cation channel family * 1.C.57 Clostridial cytotoxin family *1.C.58 The Microcin E492/C24 (Microcin E492) Family * 1.C.74 Snake cytotoxin (SCT) family * 1.C.97 Pleurotolysin pore-forming family

====1.D Non-ribosomally synthesized channels==== * 1.D.1 The Gramicidin A Channel Family * 1.D.2 The Channel-forming Syringomycin Family * 1.D.3 The Channel-Forming Syringopeptin Family * 1.D.4 The Tolaasin Channel-forming Family * 1.D.5 The Alamethicin or Peptaibol Antibiotic Channel-forming Family * 1.D.6 The Complexed Poly 3-Hydroxybutyrate Ca²⁺ Channel (cPHB-CC) Family * 1.D.7 The Beticolin Family * 1.D.8 The Saponin Family * 1.D.9 The Polyglutamine Ion Channel (PG-IC) Family * 1.D.10 The Ceramide-forming Channel Family * 1.D.11 The Surfactin Family * 1.D.12 The Beauvericin (Beauvericin) Family * 1.D.13 DNA-delivery Amphipathic Peptide Antibiotics (DAPA) * 1.D.14 The Synthetic Leu/Ser Amphipathic Channel-forming Peptide (l/S-SCP) Family * 1.D.15 The Daptomycin (Daptomycin) Family * 1.D.16 The Synthetic Amphipathic Pore-forming Heptapeptide (SAPH) Family * 1.D.17 Combinatorially-designed, Pore-forming, β-sheet Peptide Family * 1.D.18 The Pore-forming Guanosine-Bile Acid Conjugate Family * 1.D.19 Ca²⁺ Channel-forming Drug, Digitoxin Family * 1.D.20 The Pore-forming Polyene Macrolide Antibiotic/fungal Agent (PMAA) Family * 1.D.21 The Lipid Nanopore (LipNP) Family * 1.D.22 The Proton-Translocating Carotenoid Pigment, Zeaxanthin Family * 1.D.23 Phenylene Ethynylene Pore-forming Antimicrobial (PEPA) Family * 1.D.24 The Marine Sponge Polytheonamide B (pTB) Family * 1.D.25 The Arylamine Foldamer (AAF) Family * 1.D.26 The Dihydrodehydrodiconiferyl alcohol 9'-O-β-D-glucoside (DDDC9G) Family * 1.D.27 The Thiourea isosteres Family * 1.D.28 The Lipopeptaibol Family * 1.D.29 The Macrocyclic Oligocholate Family * 1.D.30 The Artificial Hydrazide-appended pillar[5]arene Channels (HAPA-C) Family * 1.D.31 The Amphotericin B Family * 1.D.32 The Pore-forming Novicidin Family * 1.D.33 The Channel-forming Polytheonamide B Family * 1.D.34 The Channel-forming Oligoester Bolaamphiphiles * 1.D.35 The Pore-forming cyclic Lipodepsipeptide Family * 1.D.36 The Oligobornene Ion Channel Family * 1.D.37 The Hibicuslide C Family * 1.D.38 The Cyclic Peptide Nanotube (cPepNT) Family * 1.D.39 The Light-controlled Azobenzene-based Amphiphilic Molecular Ion Channel (AAM-IC) Family * 1.D.40 The Protein-induced Lipid Toroidal Pore Family * 1.D.41 The Sprotetonate-type Ionophore (Spirohexanolide) Family * 1.D.42 The Phe-Arg Tripeptide-Pillar[5]Arene Channel (TPPA-C) Family * 1.D.43 The Triazole-tailored Guanosine Dinucleoside Channel (TT-GDN-C) Family * 1.D.44 The Synthetic Ion Channel with Redox-active Ferrocene (ICRF) Family * 1.D.45 The Sonoporation and Electroporation Membrane Pore (SEMP) Family * 1.D.46 The DNA Nanopore (DnaNP) Family * 1.D.47 The Pore-forming Synthetic Cyclic Peptide (PSCP) Family * 1.D.48 The Pore-forming Syringomycin E Family * 1.D.49 The Transmembrane Carotenoid Radical Channel (CRC) Family * 1.D.50 The Amphiphilic bis-Catechol Anion Transporter (AC-AT) Family * 1.D.51 The Protein Nanopore (ProNP) Family * 1.D.52 The Aromatic Oligoamide Macrocycle Nanopore (OmnNP) Family * 1.D.53 The alpha, gamma-Peptide Nanotube (a,gPepNT) Family * 1.D.54 The potassium-selective Hexyl-Benzoureido-15-Crown-5-Ether Ion Channel (HBEC) Family * 1.D.55 The Porphyrin-based Nanopore (PorNP) Family * 1.D.56 The Alpha-Aminoisobutyrate (Aib) Oligomeric Nanopore (AibNP) Family * 1.D.57 The Lipid Electro-Pore (LEP) Family * 1.D.58 The Anion Transporting Prodigiosene (Prodigiosene) Family * 1.D.59 The Anion Transporting Perenosin (Perenosin) Family * 1.D.60 The Alpha,Gamma-Cyclic Peptide (AGCP) Family * 1.D.61 The Anionophoric {{Chem name|2,6-Bis(Benzimidazol-2-yl)Pyridine}} (ABBP) Family * 1.D.62 The Bis-Triazolyl DiGuanosine Derivative Channel-forming (TDG) Family * 1.D.63 The Peptide-based Nanopore (PepNP) Family * 1.D.64 The Carbon Nanotube (CarNT) Family * 1.D.65 The Pore-forming Amphidinol (Amphidinol) Family * 1.D.66 The Helical Macromolecule Nanopore (HmmNP) Family * 1.D.67 The Crown Ether-modified Helical Peptide Ion Channel (CEHP) Family * 1.D.68 The Pore-forming Pleuronic Block Polymer (PPBP) Family * 1.D.69 The Conical Nanopore (ConNP) Family * 1.D.70 The Metallic (Au/Ag/Pt/graphene) Nanopore (MetNP) Family * 1.D.71 The Synthetic TP359 Peptide (TP359) Family * 1.D.72 The Chloride Carrier Triazine-based Tripodal Receptor (CCTTR) Family * 1.D.73 The Mesoporous Silica Nanopore (SilNP) Family * 1.D.74 The Stimulus-responsive Synthetic Rigid p-Octiphenyl Stave Pore (SSROP) Family

====1.E Holins==== {{main|Holins}}

====1.F Vesicle fusion pores==== * 1.F.1 The Synaptosomal Vesicle Fusion Pore (SVF-Pore) Family * 1.F.2 The Octameric Exocyst (Exocyst) Family

====1.G Viral fusion pores==== * 1.G.1 The Viral Pore-forming Membrane Fusion Protein-1 (VMFP1) Family * 1.G.2 The Viral Pore-forming Membrane Fusion Protein-2 (VMFP2) Family * 1.G.3 The Viral Pore-forming Membrane Fusion Protein-3 (VMFP3) Family * 1.G.4 The Viral Pore-forming Membrane Fusion Protein-4 (VMFP4) Family * 1.G.5 The Viral Pore-forming Membrane Fusion Protein-5 (VMFP5) Family * 1.G.6 The Hepadnaviral S Fusion Protein (HBV-S Protein) Family * 1.G.7 The Reovirus FAST Fusion Protein (R-FAST) Family * 1.G.8 The Arenavirus Fusion Protein (AV-FP) Family * 1.G.9 The Syncytin (Syncytin) Family * 1.G.10 The Herpes Simplex Virus Membrane Fusion Complex (HSV-MFC) Family * 1.G.11 Poxvirus Cell Entry Protein Complex (PEP-C) Family * 1.G.12 The Avian Leukosis Virus gp95 Fusion Protein (ALV-gp95) Family * 1.G.13 The Orthoreovirus Fusion-associated Small Transmembrane (FAST) Family * 1.G.14 The Influenza Virus Hemagglutinin/Fusion Pore-forming Protein (Influenza-H/FPP) Family * 1.G.15 The Autographa californica Nuclear Polyhedrosis Virus Major Envelope Glycoprotein GP64 (GP64) Family * 1.G.16 The Human Immunodeficiency Virus Type 1 (HIV-1) Fusion Peptide (HIV-FP) Family * 1.G.17 The Bovine Leukemia Virus Envelop Glycoprotein (BLV-Env) Family * 1.G.18 The SARS-CoV Fusion Peptide in the Spike Glycoprotein Precursor (SARS-FP) Family * 1.G.19 The Rotavirus Pore-forming Membrane Fusion Complex (Rotavirus MFC) Family * 1.G.20 The Hantavirus Gc Envelope Fusion Glycoprotein (Gc-EFG) Family * 1.G.21 The Epstein Barr Virus (Human Herpes Virus 4) Gp42 (Gp42) Family * 1.G.22 The Cytomegalovirus (Human Herpesvirus 5) Glycoprotein gO (gO) Family

====1.H Paracellular channels==== * 1.H.1 The Claudin Tight Junction (Claudin1) Family * 1.H.2 The Invertebrate PMP22-Claudin (Claudin2) Family

====1.I Membrane-bound channels==== * 1.I.1 Nuclear pore complex family, including karyopherins * 1.I.2 Plant plasmodesmata family

===2. Electrochemical potential-driven transporters===

====2.A Porters (uniporters, symporters, antiporters)==== {{see also|Amino acid transporter}}

*2.A.1 Major Facilitator superfamily (MFS), see also Lactose permease, Phosphate permease and Glucose transporter *2.A.2 The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family *2.A.3 The Amino Acid-Polyamine-Organocation (APC) Family *2.A.4 Cation diffusion facilitator (CDF) Family *2.A.5 Zinc (Zn²⁺)-Iron (Fe²⁺) Permease Family *2.A.6 Resistance-Nodulation-Cell Division Superfamily, see also SecDF protein-export membrane protein *2.A.7 The Drug/Metabolite Transporter (DMT) Superfamily *2.A.8 The Gluconate:H⁺ Symporter (GntP) Family *2.A.9 The Membrane Protein Insertase (YidC/Alb3/Oxa1) Family *2.A.10 The 2-Keto-3-Deoxygluconate Transporter (KdgT) Family *2.A.11 The Citrate-Mg²⁺:H⁺ (CitM) Citrate-Ca²⁺:H⁺ (CitH) Symporter (CitMHS) Family *2.A.12 ATP:ADP Antiporter Family *2.A.13 The C4-Dicarboxylate Uptake (Dcu) Family *2.A.14 Lactate Permease Family *2.A.15 The Betaine/Carnitine/Choline Transporter (BCCT) Family *2.A.16 Tellurite-resistance/Dicarboxylate Transporter Family *2.A.17 Proton-dependent Oligopeptide Transporter Family *2.A.18 The Amino Acid/Auxin Permease (AAAP) Family *2.A.19 The Ca²⁺:Cation Antiporter (CaCA) Family *2.A.20 The Inorganic Phosphate Transporter (PiT) Family *2.A.21 Solute:Sodium Symporter Family *2.A.22 The Neurotransmitter:Sodium Symporter Family *2.A.23 The Dicarboxylate/Amino Acid:Cation (Na⁺ or H⁺) Symporter (DAACS) Family *2.A.24 The 2-Hydroxycarboxylate Transporter (2-HCT) Family *2.A.25 Alanine or Glycine:Cation Symporter (AGCS) Family *2.A.26 The Branched Chain Amino Acid:Cation Symporter (LIVCS) Family *2.A.27 The Glutamate:Na⁺ Symporter (ESS) Family *2.A.28 Bile Acid:Na⁺ Symporter Family *2.A.29 Mitochondrial carrier Family *2.A.30 Cation-Chloride Cotransporter (CCC) Family *2.A.31 Anion Exchanger Family *2.A.32 The Silicon Transporter (Sit) Family *2.A.33 NhaA Na⁺:H⁺ Antiporter (NhaA) Family *2.A.34 The NhaB Na⁺:H⁺ Antiporter (NhaB) Family *2.A.35 The NhaC Na⁺:H⁺ Antiporter (NhaC) Family *2.A.36 Monovalent Cation:Proton Antiporter-1 (CPA1) Family *2.A.37 Monovalent Cation:Proton Antiporter-2 (CPA2) Family *2.A.38 K⁺ Transporter (Trk) Family *2.A.39 Nucleobase:Cation Symporter-1 (NCS1) Family *2.A.40 Nucleobase:Cation Symporter-2 (NCS2) Family *2.A.41 The Concentrative Nucleoside Transporter (CNT) Family *2.A.42 The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family *2.A.43 The Lysosomal Cystine Transporter (LCT) Family *2.A.45 Arsenite-Antimonite Efflux Family *2.A.46 The Benzoate:H⁺ Symporter (BenE) Family *2.A.47 Divalent Anion:Na⁺ Symporter (DASS) Family *2.A.48 The Reduced Folate Carrier (RFC) Family *2.A.49 Chloride Carrier/Channel (ClC) Family *2.A.50 The Glycerol Uptake (GUP) Family *2.A.51 The Chromate Ion Transporter (CHR) Family *2.A.52 The Ni²⁺-Co²⁺ Transporter (NiCoT) Family *2.A.53 Sulfate permease (SulP) Family *2.A.54 The Mitochondrial Tricarboxylate Carrier (MTC) Family *2.A.55 The Metal Ion (Mn²⁺-iron) Transporter (Nramp) Family *2.A.56 The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family *2.A.57 The Equilibrative Nucleoside Transporter (ENT) Family *2.A.58 The Phosphate:Na⁺ Symporter (PNaS) Family *2.A.59 The Arsenical Resistance-3 (ACR3) Family *2.A.60 Organo Anion Transporter (OAT) Family *2.A.61 The C4-dicarboxylate Uptake C (DcuC) Family *2.A.62 The NhaD Na⁺:H⁺ Antiporter (NhaD) Family *2.A.63 The Monovalent Cation (K⁺ or Na⁺):Proton Antiporter-3 (CPA3) Family *2.A.64 Twin Arginine Targeting (Tat) Family *2.A.65 The Bilirubin Transporter (BRT) Family *2.A.66 The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily *2.A.67 The Oligopeptide Transporter (OPT) Family *2.A.68 The p-Aminobenzoyl-glutamate Transporter (AbgT) Family *2.A.69 The Auxin Efflux Carrier (AEC) Family *2.A.70 The Malonate:Na⁺ Symporter (MSS) Family *2.A.71 The Folate-Biopterin Transporter (FBT) Family *2.A.72 The K⁺ Uptake Permease (KUP) Family *2.A.73 The Short Chain Fatty Acid Uptake (AtoE) Family *2.A.74 The 4 TMS Multidrug Endosomal Transporter (MET) Family *2.A.75 The L-Lysine Exporter (LysE) Family *2.A.76 The Resistance to Homoserine/Threonine (RhtB) Family *2.A.77 The Cadmium Resistance (CadD) Family *2.A.78 The Branched Chain Amino Acid Exporter (LIV-E) Family *2.A.79 The Threonine/Serine Exporter (ThrE) Family *2.A.80 The Tricarboxylate Transporter (TTT) Family *2.A.81 The Aspartate:Alanine Exchanger (AAEx) Family *2.A.82 The Organic Solute Transporter (OST) Family *2.A.83 The Na⁺-dependent Bicarbonate Transporter (SBT) Family *2.A.84 The Chloroplast Maltose Exporter (MEX) Family *2.A.85 The Aromatic Acid Exporter (ArAE) Family *2.A.86 The Autoinducer-2 Exporter (AI-2E) Family (Formerly the PerM Family, TC #9.B.22) *2.A.87 The Prokaryotic Riboflavin Transporter (P-RFT) Family *2.A.88 Vitamin Uptake Transporter (VUT or ECF) Family *2.A.89 The Vacuolar Iron Transporter (VIT) Family *2.A.90 Vitamin A Receptor/Transporter (STRA6) Family *2.A.91 Mitochondrial tRNA Import Complex (M-RIC) (Formerly 9.C.8) *2.A.92 The Choline Transporter-like (CTL) Family *2.A.94 The Phosphate Permease (Pho1) Family *2.A.95 The 6TMS Neutral Amino Acid Transporter (NAAT) Family *2.A.96 The Acetate Uptake Transporter (AceTr) Family *2.A.97 The Mitochondrial Inner Membrane K⁺/H⁺ and Ca²⁺/H⁺ Exchanger (LetM1) Family *2.A.98 The Putative Sulfate Exporter (PSE) Family *2.A.99 The 6TMS Ni²⁺ uptake transporter (HupE-UreJ) Family *2.A.100 The Ferroportin (Fpn) Family *2.A.101 The Malonate Uptake (MatC) Family (Formerly UIT1) *2.A.102 The 4-Toluene Sulfonate Uptake Permease (TSUP) Family *2.A.103 The Bacterial Murein Precursor Exporter (MPE) Family *2.A.104 The L-Alanine Exporter (AlaE) Family *2.A.105 The Mitochondrial Pyruvate Carrier (MPC) Family *2.A.106 The Ca²⁺:H⁺ Antiporter-2 (CaCA2) Family *2.A.107 The MntP Mn²⁺ Exporter (MntP) Family *2.A.108 The Iron/Lead Transporter (ILT) Family *2.A.109 The Tellurium Ion Resistance (TerC) Family *2.A.110 The Heme Transporter, heme-responsive gene protein (HRG) Family *2.A.111 The Na⁺/H⁺ Antiporter-E (NhaE) Family *2.A.112 The KX Blood-group Antigen (KXA) Family *2.A.113 The Nickel/cobalt Transporter (NicO) Family *2.A.114 The Putative Peptide Transporter Carbon Starvation CstA (CstA) Family *2.A.115 The Novobiocin Exporter (NbcE) Family *2.A.116 The Peptidoglycolipid Addressing Protein (GAP) Family *2.A.117 The Chlorhexadine Exporter (CHX) family *2.A.118 The Basic Amino Acid Antiporter (ArcD) Family *2.A.119 The Organo-Arsenical Exporter (ArsP) Family *2.A.120 The Putative Amino Acid Permease (PAAP) Family *2.A.121 The Sulfate Transporter (CysZ) Family *2.A.122 The LrgB/CidB holin-like auxiliary protein (LrgB/CidB) Family *2.A.123 The Sweet; PQ-loop; Saliva; MtN3 (Sweet) Family *2.A.124 The Lysine Exporter (LysO) Family *2.A.125 The Eukaryotic Riboflavin Transporter (E-RFT) Family *2.A.126 The Fatty Acid Exporter (FAX) Family *2.A.127 Enterobacterial Cardiolipin Transporter (CLT) Family

====2.B Nonribosomally synthesized porters==== *2.B.1 The Valinomycin Carrier Family *2.B.2 The Monensin Family *2.B.3 The Nigericin Family *2.B.4 The Macrotetrolide Antibiotic (MA) Family *2.B.5 The Macrocyclic Polyether (MP) Family *2.B.6 The Ionomycin Family *2.B.7 The Transmembrane α-helical Peptide Phospholipid Translocation (TMP-PLT) Family *2.B.8 The Bafilomycin A1 (Bafilomycin) Family *2.B.9 The Cell Penetrating Peptide (CPP) Functional Family *2.B.10 The Synthetic CPP, Transportan Family *2.B.11 The Calcimycin or A23187 Carrier-type Ionophore Family *2.B.12 The Salinomycin Family *2.B.13 The Tetrapyrrolic Macrocyclic Anion Antiporter (TPMC-AA) Family *2.B.14 The Lasalocid A or X-537A Ionophore (Lasalocid) Family *2.B.15 The Tris-thiourea Tripodal-based Chloride Carrier (TTT-CC) Family *2.B.16 The Halogen-bond-containing Compound Anion Carrier (HCAC) Family *2.B.17 The Isophthalaminde Derivative H⁺:Cl⁻ Co-transporter (IDC) Family *2.B.18 The Pyridine-2,6-Dicarboxamine Derivative (PDCA) H+:Cl⁻ Co-transporter Family *2.B.19 The Calix(4)pyrrole Derivative (C4P) Family *2.B.20 The Prodigiosin (Prodigiosin) Chloride/Bicarbonate Exchanger Family *2.B.21 The ortho-Phenylenediamine-bis-Urea Derivative Anion Transporter (oPDA-U) Family *2.B.22 The Imidazolium-functionalized Anion Transporter (IAT) Family *2.B.23 The Homotetrameric Transmembrane Zn²⁺/Co²⁺:Proton Synthetic Antiporter, Rocker (Rocker) Family *2.B.24 The {{Chem name|2,6-Bis(benzimidazol-2-yl)pyridine}} Anion Carrier (BBP-AC) Family *2.B.25 The Peptide-mediated Lipid Flip-Flop (PLFF) Family *2.B.26 The {{Not a typo|Bis(imidazolyl)-functionalized}} {{Not a typo|Bis(Choloyl)}} Conjugate (BIBCC) Family *2.B.27 The Tris-Urea Anion Transporter Family *2.B.29 The Anionophoric Marine Alkaloid Tambjamine Family

====2.C Ion-gradient-driven energizers==== *2.C.1 The TonB-ExbB-ExbD/TolA-TolQ-TolR (TonB) Family of Auxiliary Proteins for Energization of Outer Membrane Receptor (OMR)-mediated Active Transport

===3. Primary active transporters===

====3.A. P-P-bond hydrolysis-driven transporters==== *3.A.1 ABC transporters including BtuCD, molybdate uptake transporter, Cystic fibrosis transmembrane conductance regulator and others *3.A.2 The H⁺- or Na⁺-translocating F-type ATPase, V-type ATPase and A-type ATPase superfamily *3.A.3 The P-type ATPase Superfamily *3.A.4 The Arsenite-Antimonite efflux family *3.A.5 General secretory pathway (Sec) translocon (preprotein translocase SecY) *3.A.6 The Type III (Virulence-related) Secretory Pathway (IIISP) Family *3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family *3.A.8 The Mitochondrial Protein Translocase (MPT) Family *3.A.9 The Chloroplast Envelope Protein Translocase (CEPT or Tic-Toc) Family *3.A.10 H⁺, Na⁺-translocating Pyrophosphatase family *3.A.11 The Bacterial Competence-related DNA Transformation Transporter (DNA-T) Family *3.A.12 The Septal DNA Translocator (S-DNA-T) Family *3.A.13 The Filamentous Phage Exporter (FPhE) Family *3.A.14 The Fimbrilin/Protein Exporter (FPE) Family *3.A.15 The Outer Membrane Protein Secreting Main Terminal Branch (MTB) Family *3.A.16 The Endoplasmic Reticular Retrotranslocon (ER-RT) Family *3.A.17 The Phage T7 Injectisome (T7 Injectisome) Family *3.A.18 The Nuclear mRNA Exporter (mRNA-E) Family *3.A.19 The TMS Recognition/Insertion Complex (TRC) Family *3.A.20 The Peroxisomal Protein Importer (PPI) Family *3.A.21 The C-terminal Tail-Anchored Membrane Protein Biogenesis/ Insertion Complex (TAMP-B) Family *3.A.22 The Transcription-coupled TREX/TAP Nuclear mRNA Export Complex (TREX) Family *3.A.23 The Type VI Symbiosis/Virulence Secretory Pathway (VISP) Family *3.A.24 Type VII or ESX Protein Secretion System (T7SS) Family *3.A.25 The Symbiont-specific ERAD-like Machinery (SELMA) Family *3.A.26 The Plasmodium Translocon of Exported proteins (PTEX) Family

====3.B Decarboxylation-driven transporters==== *3.B.1 The Na⁺-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family

====3.C Methyltransfer-driven transporters==== *3.C.1 The Na⁺ Transporting Methyltetrahydromethanopterin:Coenzyme M Methyltransferase (NaT-MMM) Family

====3.D. Oxidoreduction-driven transporters==== They include a number of transmembrane cytochrome b-like proteins including coenzyme Q - cytochrome c reductase (cytochrome bc1 ); cytochrome b6f complex; formate dehydrogenase, respiratory nitrate reductase; succinate - coenzyme Q reductase (fumarate reductase); and succinate dehydrogenase. See electron transport chain.

*3.D.1 The H⁺ or Na⁺-translocating NADH Dehydrogenase ("complex I") family *3.D.2 The Proton-translocating Transhydrogenase (PTH) Family *3.D.3 The Proton-translocating Quinol:Cytochrome c Reductase) Superfamily *3.D.4 Proton-translocating Cytochrome Oxidase (COX) Superfamily *3.D.5 The Na⁺-translocating NADH:Quinone Dehydrogenase (Na-NDH or NQR) Family *3.D.6 The Putative Ion (H⁺ or Na⁺)-translocating NADH:Ferredoxin Oxidoreductase (NFO or RNF) Family *3.D.7 The H₂:Heterodisulfide Oxidoreductase (HHO) Family *3.D.8 The Na⁺- or H⁺-Pumping Formyl Methanofuran Dehydrogenase (FMF-DH) Family *3.D.9 The H⁺-translocating F420H2 Dehydrogenase (F420H2DH) Family *3.D.10 The Prokaryotic Succinate Dehydrogenase (SDH) Family

====3.E. Light absorption-driven transporters==== *Bacteriorhodopsin-like proteins including rhodopsin (see also opsin) *Bacterial photosynthetic reaction centres and photosystems I and II *Light harvesting complexes from bacteria and chloroplasts

===4. Group translocators===

====4.A Phosphotransfer-driven group translocators==== {{main|PTS-GFL superfamily}}

*4.A.1 The PTS Glucose-Glucoside (Glc) Family *4.A.2 The PTS Fructose-Mannitol (Fru) Family *4.A.3 The PTS Lactose-N,N'-Diacetylchitobiose-β-glucoside (Lac) Family *4.A.4 The PTS Glucitol (Gut) Family *4.A.5 The PTS Galactitol (Gat) Family *4.A.6 The PTS Mannose-Fructose-Sorbose (Man) Family *4.A.7 The PTS L-Ascorbate (L-Asc) Family

====4.B Nicotinamide ribonucleoside uptake transporters==== *4.B.1 The Nicotinamide Ribonucleoside (NR) Uptake Permease (PnuC) Family

====4.C Acyl CoA ligase-coupled transporters==== *4.C.1 The Proposed Fatty Acid Transporter (FAT) Family *4.C.2 The Carnitine O-Acyl Transferase (CrAT) Family *4.C.3 The Acyl-CoA Thioesterase (AcoT) Family

====4.D Polysaccharide Synthase/Exporters==== *4.D.1 The Putative Vectorial Glycosyl Polymerization (VGP) Family *4.D.2 The Glycosyl Transferase 2 (GT2) Family *4.D.3 The Glycan Glucosyl Transferase (OpgH) Family

====4.E. Vacuolar Polyphosphate Polymerase-catalyzed Group Translocators==== *4.E.1 The Vacuolar (Acidocalcisome) Polyphosphate Polymerase (V-PPP) Family

===5. Transport electron carriers=== ====5.A Transmembrane 2-electron transfer carriers==== *5.A.1 The Disulfide Bond Oxidoreductase D (DsbD) Family *5.A.2 The Disulfide Bond Oxidoreductase B (DsbB) Family *5.A.3 The Prokaryotic Molybdopterin-containing Oxidoreductase (PMO) Family

====5.B Transmembrane 1-electron transfer carriers==== *5.B.1 The Phagocyte (gp91phox) NADPH Oxidase Family *5.B.2 The Eukaryotic Cytochrome b561 (Cytb561) Family *5.B.3 The Geobacter Nanowire Electron Transfer (G-NET) Family *5.B.4 The Plant Photosystem I Supercomplex (PSI) Family *5.B.5 The Extracellular Metal Oxido-Reductase (EMOR) Family *5.B.6 The Transmembrane Epithelial Antigen Protein-3 Ferric Reductase (STEAP) Family *5.B.7 The YedZ (YedZ) Family *5.B.8 The Trans-Outer Membrane Electron Transfer Porin/Cytochrome Complex (ET-PCC) Family *5.B.9 The Porin-Cytochrome c (Cyc2) Family

===8. Accessory factors involved in transport===

====8.A Auxiliary transport proteins====

====8.B Ribosomally synthesized protein/peptide toxins that target channels and carriers====

====8.C Non-ribosomally synthesized toxins that target channels and carriers====

===9. Incompletely characterized transport systems===

====9.A Recognized transporters of unknown biochemical mechanism====

====9.B Putative transport proteins====

====9.C Functionally characterized transporters lacking identified sequences====

==References== {{reflist}}

==External links== * [http://www.tcdb.org/ Transporter Classification Database] * [http://www.chem.qmul.ac.uk/iubmb/mtp/ List] at qmul.ac.uk * {{cite journal |vauthors=Saier MH, Tran CV, Barabote RD |title=TCDB: the Transporter Classification Database for membrane transport protein analyses and information |journal=Nucleic Acids Res. |volume=34 |issue=Database issue |pages=D181–6 |date=January 2006 |pmid=16381841 |pmc=1334385 |doi=10.1093/nar/gkj001 |url=}} * {{cite journal |vauthors=Busch W, Saier MH |title=The transporter classification (TC) system, 2002 |journal=Crit. Rev. Biochem. Mol. Biol. |volume=37 |issue=5 |pages=287–337 |year=2002 |pmid=12449427 |doi= 10.1080/10409230290771528|s2cid=10558982 }} * [http://www.guidetopharmacology.org/GRAC/ReceptorFamiliesForward?type=TRANSPORTER Classification of human transporters in pharmacology]

{{Ion channels}} {{Pore-forming toxins}} {{Non-ribosomally synthesized channels}} {{Vesicular transport proteins}} {{Membrane transport proteins}} {{Nonribosomally synthesized porters}} {{ABC transporters}} {{Ion pumps}} {{Oxidoreduction-driven transporters}}

Category:Biochemistry databases Category:Transport proteins Category:Transmembrane proteins Category:Protein classification