Nonsteroidal

{{Short description|Type of drug}} A '''nonsteroidal''' compound is a drug that is neither a steroid nor a steroid derivative.<ref name="Pavlik2012">{{cite book|author=Edward J. Pavlik|title=Estrogens, Progestins, and Their Antagonists: Health Issues|url=https://books.google.com/books?id=LAnpBwAAQBAJ&pg=PA166|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-1-4612-4096-9|pages=166–}}</ref><ref name="(Emeritus)University2005">{{cite book|author1=Thomas Nogrady Professor of Medicinal Chemistry Concordia University (Emeritus)|author2=Donald F. Weaver Canada Research Chair and Professor of Medicine and Chemistry Dalhousie University|title=Medicinal Chemistry : A Molecular and Biochemical Approach: A Molecular and Biochemical Approach|url=https://books.google.com/books?id=UnKa7zARGV0C&pg=PA322|date=27 July 2005|publisher=Oxford University Press, USA|isbn=978-0-19-802645-7|pages=322–}}</ref> Nonsteroidal anti-inflammatory drugs (NSAIDs) are distinguished from corticosteroids as a class of anti-inflammatory agents.<ref name="Buer_2014">{{cite journal | vauthors = Buer JK | title = Origins and impact of the term 'NSAID' | journal = Inflammopharmacology | volume = 22 | issue = 5 | pages = 263–7 | date = Oct 2014 | url = https://www.researchgate.net/publication/264248818 | pmid = 25064056 | doi = 10.1007/s10787-014-0211-2 | hdl = 10852/45403 | s2cid = 16777111 | hdl-access = free }}</ref>

==List of nonsteroidal steroid receptor modulators== Examples include the following:<ref name="Pavlik2012" /><ref name="(Emeritus)University2005" /> * Estrogens: benzestrol, bifluranol, estrobin (DBE), diethylstilbestrol (stilbestrol), dienestrol, erteberel, fosfestrol, hexestrol (dihydroxystilbestrol), methallenestril, methestrol, methestrol dipropionate, paroxypropione, prinaberel, and triphenylethylene, as well as many xenoestrogens * {{abbrlink|SERMs|Selective estrogen receptor modulators}}: acolbifene, afimoxifene, arzoxifene, bazedoxifene, broparestrol, chlorotrianisene, clomifene, clomifenoxide, cyclofenil, droloxifene, enclomifene, endoxifen, ethamoxytriphetol, fispemifene, idoxifene, lasofoxifene, levormeloxifene, miproxifene, nafoxidine, nitromifene, ormeloxifene, ospemifene, panomifene, pipendoxifene, raloxifene, tamoxifen, toremifene, trioxifene, zindoxifene, zuclomifene * Antiandrogens: apalutamide, bicalutamide, cimetidine, darolutamide, DIMP, enzalutamide, EPI-001, EPI-506, flutamide, hydroxyflutamide, inocoterone, inocoterone acetate, nilutamide, RU-58642, RU-58841, and topilutamide * {{abbrlink|SARMs|Selective androgen receptor modulators}}: AC-262,356, acetothiolutamide, andarine, BMS-564,929, enobosarm (ostarine), LGD-2226, LGD-3303, LGD-4033, S-23, and S-40503 * Aromatase inhibitors: anastrozole, aminoglutethimide, fadrozole, finrozole, letrozole, liarozole, norendoxifen, rogletimide (pyridoglutethimide), vorozole * Other steroidogenesis inhibitors: aminoglutethimide, ketoconazole, orteronel, seviteronel, others * Miscellaneous: tanaproget (progestogen), finerenone (antimineralocorticoid), esaxerenone (antimineralocorticoid), apararenone (antimineralocorticoid), AZD5423 (glucocorticoid), mapracorat ({{abbrlink|SGRM|Selective glucocorticoid receptor modulator}})

==References== {{Reflist|30em}}

==Further reading== * {{cite journal | vauthors = Miquel JF, Gilbert J | title = A chemical classification of nonsteroidal antagonists of sex-steroid hormone action | journal = J. Steroid Biochem. | volume = 31 | issue = 4B | pages = 525–44 | year = 1988 | doi = 10.1016/0022-4731(88)90004-0 | pmid = 3059055 }} * {{cite journal|last1=Buijsman|first1=Rogier|last2=Hermkens|first2=Pedro|last3=Rijn|first3=Rachel|last4=Stock|first4=H.|last5=Teerhuis|first5=N.|title=Non-Steroidal Steroid Receptor Modulators|journal=Current Medicinal Chemistry|volume=12|issue=9|year=2005|pages=1017–1075|issn=0929-8673|doi=10.2174/0929867053764671|pmid=16821162}} * {{cite journal | vauthors = Hermkens PH, Kamp S, Lusher S, Veeneman GH | title = Non-steroidal steroid receptor modulators | journal = IDrugs | volume = 9 | issue = 7 | pages = 488–94 | year = 2006 | pmid = 16821162 | doi = 10.2174/0929867053764671}}

{{Navboxes | title = Steroid receptor modulators | list1 = {{Androgen receptor modulators}} {{Estrogen receptor modulators}} {{Glucocorticoid receptor modulators}} {{Mineralocorticoid receptor modulators}} {{Progesterone receptor modulators}} }}

Category:Pharmacology