{{Short description|Tumor of the membranes surrounding the brain and spinal cord (meninges)}} {{cs1 config|name-list-style=vanc}} {{Infobox medical condition (new) | name = Meningioma | synonyms = Meningeal tumor<ref name=NCI2016/> | image = Huge Meningioma.jpg | caption = An MRI of the brain, demonstrating the appearance of a meningioma | field = Neurosurgery, Neuro-oncology | symptoms = None, seizures, dementia, trouble talking, vision problems, one sided weakness<ref name=Fer2018/> | complications = | onset = Adults<ref name=NCI2016/> | duration = | types = WHO Grade 1, 2, or 3<ref name=NCI2016/> | causes = | risks = Ionizing radiation, family history<ref name=Wi2010/> | diagnosis = Medical imaging<ref name=Fer2018/> | differential = Haemangiopericytoma, lymphoma, schwannoma, solitary fibrous tumour, metastasis<ref name=Sta2017/> | prevention = | treatment = Observation, surgery, radiation therapy<ref name=Fer2018/> | medication = Anticonvulsants, corticosteroids<ref name=Fer2018/> | prognosis = 95% ten year survival with complete removal<ref>{{cite book| vauthors = Goodman C, Fuller KS |title=Pathology for the Physical Therapist Assistant – E-Book|date=2011|publisher=Elsevier Health Sciences|isbn=978-1-4377-0893-6 |page=192 |url= https://books.google.com/books?id=eJb5RHpCF6oC&pg=SL5-PA190 |language=en|url-status=live|archive-url=https://web.archive.org/web/20170910183411/https://books.google.com/books?id=eJb5RHpCF6oC&pg=SL5-PA190|archive-date=2017-09-10}}</ref> | frequency = c. 1 per 1,000 (US)<!-- prevalence --><ref name=Wi2010/> | deaths = }} <!-- Definition and symptoms --> '''Meningioma''', also known as '''meningeal tumor''', is typically a slow-growing tumor that forms from the meninges, the membranous layers surrounding the brain and spinal cord.<ref name=NCI2016>{{cite web|title=Adult Central Nervous System Tumors Treatment|url=https://www.cancer.gov/types/brain/patient/adult-brain-treatment-pdq|website=National Cancer Institute|language=en|date=26 August 2016|url-status=live|archive-url=https://web.archive.org/web/20170728010619/https://www.cancer.gov/types/brain/patient/adult-brain-treatment-pdq|archive-date=28 July 2017}}</ref> Symptoms depend on the location and occur as a result of the tumor pressing on nearby tissue.<ref name=Wi2010>{{cite journal | vauthors = Wiemels J, Wrensch M, Claus EB | title = Epidemiology and etiology of meningioma | journal = Journal of Neuro-Oncology | volume = 99 | issue = 3 | pages = 307–314 | date = September 2010 | pmid = 20821343 | pmc = 2945461 | doi = 10.1007/s11060-010-0386-3 }}</ref><ref name=WCR2014>{{cite book|title=World Cancer Report 2014|date=2014|publisher=World Health Organization|isbn=978-92-832-0429-9|pages=Chapter 5.16}}</ref> Many cases never produce symptoms.<ref name=Fer2018/> Occasionally seizures, dementia, trouble talking, vision problems, one sided weakness, or loss of bladder control may occur.<ref name=Fer2018/>
<!-- Cause and diagnosis --> Risk factors include exposure to ionizing radiation such as during radiation therapy, a family history of the condition, and neurofibromatosis type 2.<ref name=Fer2018/><ref name=Wi2010/> They appear to be able to form from a number of different types of cells including arachnoid cells.<ref name=NCI2016/><ref name=Fer2018>{{cite book| vauthors = Ferri FF |title=Ferri's Clinical Advisor 2018 E-Book: 5 Books in 1 |date=2017 |publisher=Elsevier Health Sciences|isbn=978-0-323-52957-0|page=809|url=https://books.google.com/books?id=wGclDwAAQBAJ&pg=PA809|language=en|url-status=live|archive-url=https://web.archive.org/web/20170910183411/https://books.google.com/books?id=wGclDwAAQBAJ&pg=PA809|archive-date=2017-09-10}}</ref> Diagnosis is typically by medical imaging.<ref name=Fer2018/>
<!-- Treatment and prognosis --> If there are no symptoms, periodic observation may be all that is required.<ref name=Fer2018/> Most cases that result in symptoms can be cured by surgery.<ref name=NCI2016/> Following complete removal fewer than 20% recur.<ref name=Fer2018/> If surgery is not possible or all the tumor cannot be removed, radiosurgery may be helpful.<ref name=Fer2018/> Chemotherapy has not been found to be useful.<ref name=Fer2018/> A small percentage grow rapidly and are associated with worse outcomes.<ref name=NCI2016/>
<!-- Epidemiology and history --> About one per thousand people in the United States are currently affected.<ref name=Wi2010/> Onset is usually in adults.<ref name=NCI2016/> In this group they represent about 30% of brain tumors.<ref name=Sta2017>{{cite journal | vauthors = Starr CJ, Cha S | title = Meningioma mimics: five key imaging features to differentiate them from meningiomas | journal = Clinical Radiology | volume = 72 | issue = 9 | pages = 722–728 | date = September 2017 | pmid = 28554578 | doi = 10.1016/j.crad.2017.05.002 }}</ref> Women are affected about twice as often as men.<ref name=Wi2010/> Meningiomas were reported as early as 1614 by Felix Plater.<ref name=Lee2008>{{cite book| vauthors = Lee JH |title=Meningiomas: Diagnosis, Treatment, and Outcome|url=https://books.google.com/books?id=c_j9piinzy8C&pg=PA3|date=2008-12-11|publisher=Springer Science & Business Media|isbn=978-1-84628-784-8|pages=3–13}}</ref>
==Signs and symptoms== [[File:Meningioma seen at autopsy.jpg|thumb|Meningioma seen at autopsy, as a tumor of the dura mater extending into the cranial cavity, and can be detached from the bone along with the rest of the dura mater]] Small tumors (e.g., < 2.0 cm) usually are incidental findings at autopsy without having caused symptoms. Larger tumors may cause symptoms, depending on the size and location.{{citation needed|date=October 2021}} * Focal seizures may be caused by meningiomas that overlie the cerebrum. * Progressive spastic weakness in legs and incontinence may be caused by tumors that overlie the parasagittal frontoparietal region.{{Citation needed|date=March 2012}} * Tumors of the Sylvian aqueduct may cause myriad motor, sensory, aphasic, and seizure symptoms, depending on the location. * Increased intracranial pressure eventually occurs, but is less frequent than in gliomas. * Diplopia (Double vision) or uneven pupil size may be symptoms if related pressure causes a third and/or sixth nerve palsy.
==Causes== The causes of meningiomas are not well understood.<ref>{{cite web|url=https://www.mayoclinic.com/health/meningioma/DS00901/DSECTION=causes|title=Meningioma|publisher=Mayo Clinic|access-date=February 27, 2012|url-status=live|archive-url=https://web.archive.org/web/20120228223235/http://www.mayoclinic.com/health/meningioma/DS00901/DSECTION%3Dcauses|archive-date=February 28, 2012}}</ref> Most cases are sporadic, appearing randomly, while some are familial. Persons who have undergone radiation, especially to the scalp, are more at risk for developing meningiomas, as are those who have had a brain injury.<ref name="pmid8334619">{{cite journal | vauthors = Longstreth WT, Dennis LK, McGuire VM, Drangsholt MT, Koepsell TD | title = Epidemiology of intracranial meningioma | journal = Cancer | volume = 72 | issue = 3 | pages = 639–648 | date = August 1993 | pmid = 8334619 | doi = 10.1002/1097-0142(19930801)72:3<639::AID-CNCR2820720304>3.0.CO;2-P | doi-access = free }}</ref> Atomic bomb survivors from Hiroshima had a higher than typical frequency of developing meningiomas, with the incidence increasing the closer that they were to the site of the explosion. Dental X-rays are correlated with an increased risk of meningioma, in particular for people who had frequent dental X-rays in the past, when the X-ray dose of a dental X-ray was higher than in the present.<ref name="pmid22492363">{{cite journal | vauthors = Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M | title = Dental x-rays and risk of meningioma | journal = Cancer | volume = 118 | issue = 18 | pages = 4530–4537 | date = September 2012 | pmid = 22492363 | pmc = 3396782 | doi = 10.1002/cncr.26625 }}</ref>
According to Medscape Medical News article by Megan Brooks dated 12/18/2025, "The FDA has approved a label change on the long-acting injectable contraceptive depot medroxyprogesterone acetate, commonly known as Depo-Provera, to warn users of a potential risk of meningioma."{{cn|date=April 2026}}
Having excess body fat increases the risk.<ref>{{cite journal | vauthors = Niedermaier T, Behrens G, Schmid D, Schlecht I, Fischer B, Leitzmann MF | title = Body mass index, physical activity, and risk of adult meningioma and glioma: A meta-analysis | journal = Neurology | volume = 85 | issue = 15 | pages = 1342–1350 | date = October 2015 | pmid = 26377253 | doi = 10.1212/WNL.0000000000002020 | s2cid = 38916981 }}</ref> In 2020, the European Medicine Agency issued a warning that high doses of cyproterone acetate may contribute to risk of meningioma, and to use the minimum dosage or alternative treatment for most indications, with the exception of prostate carcinoma.<ref>EMA. European Medicines Agency. Assessment report cyproterone. 13 February 2020. https://www.ema.europa.eu/en/documents/referral/cyproterone-article-31-referral-prac-assessment-report_en.pdf. Accessed 9 Apr 2020.</ref>
A 2012 review found that mobile telephone use was unrelated to meningioma.<ref>{{cite journal | vauthors = Repacholi MH, Lerchl A, Röösli M, Sienkiewicz Z, Auvinen A, Breckenkamp J, d'Inzeo G, Elliott P, Frei P, Heinrich S, Lagroye I, Lahkola A, McCormick DL, Thomas S, Vecchia P | display-authors = 6 | title = Systematic review of wireless phone use and brain cancer and other head tumors | journal = Bioelectromagnetics | volume = 33 | issue = 3 | pages = 187–206 | date = April 2012 | pmid = 22021071 | doi = 10.1002/bem.20716 | bibcode = 2009BioEl..30...45D | s2cid = 13519292 }}</ref>
People with neurofibromatosis type 2 (NF-2) have a 50% chance of developing one or more meningiomas.<ref name="Bachir Shah Shapiro Koehler 2021 p. 690">{{cite journal | last1=Bachir | first1=Suha | last2=Shah | first2=Sanjit | last3=Shapiro | first3=Scott | last4=Koehler | first4=Abigail | last5=Mahammedi | first5=Abdelkader | last6=Samy | first6=Ravi N. | last7=Zuccarello | first7=Mario | last8=Schorry | first8=Elizabeth | last9=Sengupta | first9=Soma | title=Neurofibromatosis Type 2 (NF2) and the Implications for Vestibular Schwannoma and Meningioma Pathogenesis | journal=International Journal of Molecular Sciences | publisher=MDPI AG | volume=22 | issue=2 | date=January 12, 2021 | issn=1422-0067 | doi=10.3390/ijms22020690 | page=690| doi-access=free | pmid=33445724 | pmc=7828193 }}</ref>
92% of meningiomas are benign. 8% are either atypical or malignant.<ref name=Lee2008/>
===Genetics=== The most frequent genetic mutations (~50%) involved in meningiomas are inactivation mutations in the neurofibromatosis 2 gene (merlin) on chromosome 22q.<ref name="Bachir Shah Shapiro Koehler 2021 p. 690"/>
''TRAF7'' mutations are present in about one-fourth of meningiomas. Mutations in the ''TRAF7'', ''KLF4'', ''AKT1'', and ''SMO'' genes are commonly expressed in benign skull-base meningiomas. Mutations in NF2 are commonly expressed in meningiomas located in the cerebral and cerebellar hemispheres.<ref>{{cite journal | vauthors = Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K, Avşar T, Li J, Murray PB, Henegariu O, Yilmaz S, Günel JM, Carrión-Grant G, Yilmaz B, Grady C, Tanrikulu B, Bakircioğlu M, Kaymakçalan H, Caglayan AO, Sencar L, Ceyhun E, Atik AF, Bayri Y, Bai H, Kolb LE, Hebert RM, Omay SB, Mishra-Gorur K, Choi M, Overton JD, Holland EC, Mane S, State MW, Bilgüvar K, Baehring JM, Gutin PH, Piepmeier JM, Vortmeyer A, Brennan CW, Pamir MN, Kiliç T, Lifton RP, Noonan JP, Yasuno K, Günel M | display-authors = 6 | title = Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO | journal = Science | volume = 339 | issue = 6123 | pages = 1077–1080 | date = March 2013 | pmid = 23348505 | pmc = 4808587 | doi = 10.1126/science.1233009 | bibcode = 2013Sci...339.1077C }}</ref>
==Pathophysiology== [[File:Histopathology of meningioma.png|thumb|Histopathology of a typical WHO grade 1 meningioma, H&E stain. It is of the meningothelial histologic type, which is the most common meningioma type. It shows its typical findings:<br />- A woven architectural pattern<br />- Psammoma bodies (spheroid calcifications)<br />- Syncytial cells (having indistinct cell membranes) with eosinophilic (pink) cytoplasms<br />- Round uniform nuclei<br />- Whorls (concentric cell arrangements)<ref>Image by Mikael Häggström, MD. Reference for typical findings: {{cite web|url=https://www.pathologyoutlines.com/topic/cnstumormeningiomageneral.html|title=Meningioma|website=Pathology Outlines|author=Chunyu Cai, M.D., Ph.D.}} Last author update: 10 November 2021</ref>]] [[Image:Meningioma high mag.jpg|thumb|right|Micrograph of a meningioma showing the characteristic whorling, HPS stain]] [[Image:Meningioma - brain invasion - high mag.jpg|thumb|right|Micrograph of a meningioma with brain invasion (WHO Grade II). The tumour (bottom/right of image) has the typical "pushing border" invasion into the cerebral cortex (top/left of image), HPS stain.]] Meningiomas arise from arachnoidal cap cells,<ref name="urlmoon.ouhsc.edu">{{cite web |url=http://moon.ouhsc.edu/kfung/jty1/Com/Com306-1-Diss.htm |title=moon.ouhsc.edu |access-date=2008-11-30 |archive-url=https://web.archive.org/web/20081205014303/http://moon.ouhsc.edu/kfung/JTY1/Com/Com306-1-Diss.htm |archive-date=2008-12-05 }}</ref> most of which are near the vicinity of the venous sinuses, and this is the site of greatest prevalence for meningioma formation. Some subtypes may arise from the pial cap cells that migrate during the development together with blood vessels into the brain parenchyma.<ref name=":0" /> They most frequently are attached to the dura over the superior parasagittal surface of frontal and parietal lobes, along the sphenoid ridge, in the olfactory grooves, the Sylvian region, superior cerebellum along the ''falx cerebri'', cerebellopontine angle, and the spinal cord. The tumor is usually gray, well-circumscribed, and takes on the form of the space it occupies. They usually are dome-shaped, with the base lying on the dura.{{citation needed|date=July 2021}}
===Locations=== * Falx cerebri '''falcine''' (25%) * Convexity (surface of the brain) (19%) * Sphenoid ridge (17%) * Suprasellar (9%) * Posterior fossa (8%) * Olfactory groove (8%) * Middle fossa/Meckel's cave (4%) * Tentorial (3%) * Peri-torcular (3%) * Intraparenchymal (rare)<ref name=":0">{{cite journal | vauthors = Papic V, Lasica N, Jelaca B, Vuckovic N, Kozic D, Djilvesi D, Fimic M, Golubovic J, Pajicic F, Vulekovic P | display-authors = 6 | title = Primary Intraparenchymal Meningiomas: A Case Report and a Systematic Review | journal = World Neurosurgery | volume = 153 | pages = 52–62 | date = September 2021 | pmid = 34242832 | doi = 10.1016/j.wneu.2021.06.139 }}</ref>
Other uncommon locations are the lateral ventricle, foramen magnum, and the orbit/optic nerve sheath.<ref name=Lee2008/> Meningiomas also may occur as a spinal tumor, more often in women than in men. This occurs more often in Western countries than Asian.{{citation needed|date=October 2021}} [[File:Meningioma showing Psammoma body.jpg|thumbnail|Micrograph of a psammoma body in the centre of the field in a meningioma of brain. H&E stain.]] Histologically, meningioma cells are relatively uniform, with a tendency to encircle one another, forming whorls and psammoma bodies (laminated calcific concretions).<ref name="urlNeuropathology For Medical Students">{{cite web |url=http://www.pathology.vcu.edu/WirSelfInst/neuro_medStudents/tumor-1.html |title=Neuropathology For Medical Students |access-date=2008-11-30 |archive-url=https://web.archive.org/web/20090107042703/http://www.pathology.vcu.edu/WirSelfInst/neuro_medStudents/tumor-1.html |archive-date=2009-01-07 }}</ref> As such, they also have a tendency to calcify and are highly vascularized.{{citation needed|date=June 2022}}
Meningiomas often are considered benign tumors that can be removed by surgery, but most recurrent meningiomas correspond to histologic benign tumors. The metabolic phenotype of these benign recurrent meningiomas indicated an aggressive metabolism resembling that observed for atypical meningioma.<ref name="monleon">{{cite journal | vauthors = Monleón D, Morales JM, Gonzalez-Segura A, Gonzalez-Darder JM, Gil-Benso R, Cerdá-Nicolás M, López-Ginés C | title = Metabolic aggressiveness in benign meningiomas with chromosomal instabilities | journal = Cancer Research | volume = 70 | issue = 21 | pages = 8426–8434 | date = November 2010 | pmid = 20861191 | doi = 10.1158/0008-5472.CAN-10-1498 | doi-access = free }}</ref>
==Diagnosis== thumb|A meningioma that previously had been operated on, with surrounding edema thumb|MRI image of a meningioma with contrast thumb|Low-grade and high-grade meningioma. H&E stain.<ref>{{cite journal| author=Wu C, Zhong J, Lin L, Chen Y, Xue Y, Shi P| title=Segmentation of HE-stained meningioma pathological images based on pseudo-labels. | journal=PLOS ONE | year= 2022 | volume= 17 | issue= 2 | article-number= e0263006 | pmid=35120175 | doi=10.1371/journal.pone.0263006 | pmc=8815980 | doi-access=free | bibcode=2022PLoSO..1763006W }}<br />- Creative Commons Attribution 4.0 International license</ref> thumb|Histologic variants of meningioma, H&E stain<ref>{{cite journal| author=Brabec J, Friedjungová M, Vašata D, Englund E, Bengzon J, Knutsson L | display-authors=etal| title=Meningioma microstructure assessed by diffusion MRI: An investigation of the source of mean diffusivity and fractional anisotropy by quantitative histology. | journal=NeuroImage Clin | year= 2023 | volume= 37 | issue= | article-number= 103365 | pmid=36898293 | doi=10.1016/j.nicl.2023.103365 | pmc=10020119 }}<br />- "This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/)"</ref> Meningiomas are visualized readily with contrast CT, MRI with gadolinium,<ref>{{Radiopaedia|Meningioma}}</ref> and arteriography, all attributed to the fact that meningiomas are extra-axial and vascularized. CSF protein levels are usually found to be elevated when lumbar puncture is used to obtain spinal fluid.{{citation needed|date=July 2021}} On T1-weighted contrast-enhanced MRI, they may show a typical dural tail sign absent in some rare forms of meningiomas.<ref name=":0" />
Although the majority of meningiomas are benign, they may have malignant presentations. Classification of meningiomas are based upon the WHO classification system.<ref name="pmid15540215">{{cite journal | vauthors = Wrobel G, Roerig P, Kokocinski F, Neben K, Hahn M, Reifenberger G, Lichter P | title = Microarray-based gene expression profiling of benign, atypical and anaplastic meningiomas identifies novel genes associated with meningioma progression | journal = International Journal of Cancer | volume = 114 | issue = 2 | pages = 249–256 | date = March 2005 | pmid = 15540215 | doi = 10.1002/ijc.20733 | doi-access = free }}</ref> * Benign (Grade I) – (90%) – meningothelial, fibrous, transitional, psammomatous, angioblastic * Atypical (Grade II) – (7%) – chordoid, clear cell, atypical (includes brain invasion) * Anaplastic/malignant (Grade III) – (2%) – papillary, rhabdoid, anaplastic (most aggressive) In a 2008 review of the latter two categories, atypical and anaplastic-meningioma cases, the mean overall survival for atypical meningiomas was found to be 11.9 years vs. 3.3 years for anaplastic meningiomas. Mean relapse-free survival for atypical meningiomas was 11.5 years vs. 2.7 years for anaplastic meningiomas.<ref name="pmid17766430">{{cite journal | vauthors = Yang SY, Park CK, Park SH, Kim DG, Chung YS, Jung HW | title = Atypical and anaplastic meningiomas: prognostic implications of clinicopathological features | journal = Journal of Neurology, Neurosurgery, and Psychiatry | volume = 79 | issue = 5 | pages = 574–580 | date = May 2008 | pmid = 17766430 | doi = 10.1136/jnnp.2007.121582 | hdl-access = free | s2cid = 35950380 | hdl = 10371/62023 }}</ref>
Malignant anaplastic meningioma is aggressive. Although anaplastic meningioma has higher chances of distant metastasis than the other two types, the overall incidence of meningioma metastasis is only 0.18%; which is considered rare.<ref>{{cite journal | vauthors = Vuong HG, Ngo TN, Dunn IF | title = Incidence, risk factors, and prognosis of meningiomas with distant metastases at presentation | journal = Neuro-Oncology Advances | volume = 3 | issue = 1 | article-number = vdab084 | date = 2021-01-01 | pmid = 34345819 | pmc = 8324175 | doi = 10.1093/noajnl/vdab084 }}</ref> Even if, by general rule, neoplasms of the nervous system (brain tumors) cannot metastasize into the body because of the blood–brain barrier, anaplastic meningioma can. Although they are inside the cerebral cavity, they are located on the bloodside of the BBB, because meningiomas tend to be connected to blood vessels. Thus, cancerized cells can escape into the bloodstream, which is why meningiomas, when they metastasize, often turn up around the lungs.{{citation needed|date=July 2021}}
Anaplastic meningioma and hemangiopericytoma are difficult to distinguish, even by pathological means, as they look similar, especially, if the first occurrence is a meningeal tumor, and both tumors occur in the same types of tissue.{{Citation needed|date=February 2012}}
Although usually benign a "petro-clival" menigioma is typically fatal without treatment due to its location. Until the 1970s no treatment was available for this type of meningioma; however, since that time a range of surgical and radiological treatments have evolved. Nevertheless, the treatment of this type of meningioma remains a challenge with relatively frequent poor outcomes.<ref>{{cite journal | vauthors = Maurer AJ, Safavi-Abbasi S, Cheema AA, Glenn CA, Sughrue ME | title = Management of petroclival meningiomas: a review of the development of current therapy | journal = Journal of Neurological Surgery. Part B, Skull Base | volume = 75 | issue = 5 | pages = 358–367 | date = October 2014 | pmid = 25276602 | pmc = 4176539 | doi = 10.1055/s-0034-1373657 }}</ref>
==Prevention== The risk of meningioma can be reduced by maintaining a normal body weight,<ref>{{cite journal | vauthors = Lauby-Secretan B, Scoccianti C, Loomis D, Grosse Y, Bianchini F, Straif K | title = Body Fatness and Cancer--Viewpoint of the IARC Working Group | journal = The New England Journal of Medicine | volume = 375 | issue = 8 | pages = 794–798 | date = August 2016 | pmid = 27557308 | pmc = 6754861 | doi = 10.1056/nejmsr1606602 }}</ref> and by avoiding unnecessary dental x-rays.<ref>{{cite web |url=http://www.webmd.com/brain/news/20120410/dental-x-rays-linked-brain-tumors |title=Dental X-rays Linked to Brain Tumors |access-date=2016-09-23 |url-status=live |archive-url=https://web.archive.org/web/20160927032101/http://www.webmd.com/brain/news/20120410/dental-x-rays-linked-brain-tumors |archive-date=2016-09-27 }}</ref>
==Treatment==
===Observation=== Observation with close imaging follow-up may be used in select cases if a meningioma is small and asymptomatic. In a retrospective study on 43 patients, 63% of patients were found to have no growth on follow-up, and the 37% found to have growth at an average of 4 mm / year.<ref>{{cite journal | vauthors = Herscovici Z, Rappaport Z, Sulkes J, Danaila L, Rubin G | title = Natural history of conservatively treated meningiomas | journal = Neurology | volume = 63 | issue = 6 | pages = 1133–1134 | date = September 2004 | pmid = 15452322 | doi = 10.1212/01.wnl.0000138569.45818.50 | s2cid = 43221656 }}</ref> In this study, younger patients were found to have tumors that were more likely to have grown on repeat imaging; thus are poorer candidates for observation. In another study, clinical outcomes were compared for 213 patients undergoing surgery vs. 351 patients under watchful observation.<ref>{{cite journal | vauthors = Yano S, Kuratsu J | title = Indications for surgery in patients with asymptomatic meningiomas based on an extensive experience | journal = Journal of Neurosurgery | volume = 105 | issue = 4 | pages = 538–543 | date = October 2006 | pmid = 17044555 | doi = 10.3171/jns.2006.105.4.538 | s2cid = 40577595 }}</ref> Only 6% of the conservatively treated patients developed symptoms later, while among the surgically treated patients, 5.6% developed persistent morbid condition, and 9.4% developed surgery-related morbid condition.{{citation needed|date=July 2021}}
Observation is not recommended in tumors already causing symptoms. Furthermore, close follow-up with imaging is required with an observation strategy to rule out an enlarging tumor.<ref>{{cite journal | vauthors = Olivero WC, Lister JR, Elwood PW | title = The natural history and growth rate of asymptomatic meningiomas: a review of 60 patients | journal = Journal of Neurosurgery | volume = 83 | issue = 2 | pages = 222–224 | date = August 1995 | pmid = 7616265 | doi = 10.3171/jns.1995.83.2.0222 | doi-access = }}</ref>
===Surgery=== Meningiomas can usually be surgically resected (removed) and result in a permanent cure if the tumor is superficial on the dural surface and easily accessible. Transarterial embolization has become a standard procedure in preoperative management of meningiomas.<ref name="pmid15355012">{{cite journal | vauthors = Dowd CF, Halbach VV, Higashida RT | title = Meningiomas: the role of preoperative angiography and embolization | journal = Neurosurgical Focus | volume = 15 | issue = 1 | article-number = E10 | date = July 2003 | pmid = 15355012 | doi = 10.3171/foc.2003.15.1.10 |url=http://www.aans.org/education/journal/neurosurgical/july03/15-1-10.pdf |access-date=2007-01-02 |archive-url=https://web.archive.org/web/20070110093430/http://www.aans.org/education/journal/neurosurgical/july03/15-1-10.pdf |archive-date=2007-01-10 }}</ref> If invasion of the adjacent bone occurs, total removal is nearly impossible. It is rare for benign meningiomas to become malignant.{{citation needed|date=July 2021}}
The probability of a tumor recurring or growing after surgery may be estimated by comparing the tumor's WHO (World Health Organization) grade and by the extent of surgery by the Simpson Criteria.<ref>{{cite journal | vauthors = Simpson D | title = The recurrence of intracranial meningiomas after surgical treatment | journal = Journal of Neurology, Neurosurgery, and Psychiatry | volume = 20 | issue = 1 | pages = 22–39 | date = February 1957 | pmid = 13406590 | pmc = 497230 | doi = 10.1136/jnnp.20.1.22 }}</ref>
{| border="1" style="margin:1em auto;" ! Simpson Grade !! Completeness of Resection !! 10-year Recurrence |- | Grade I || complete removal including resection of underlying bone and associated dura || style="text-align:center;"| 9% |- | Grade II || complete removal and coagulation of dural attachment || style="text-align:center;"| 19% |- | Grade III || complete removal without resection of dura or coagulation || style="text-align:center;"| 29% |- | Grade IV || subtotal resection || style="text-align:center;"| 40% |- |Grade V |simple decompression ± biopsy |n/a |}
===Radiation therapy=== Radiation therapy may include photon-beam or proton-beam treatment, or fractionated external beam radiation. Radiosurgery may be used in lieu of surgery in small tumors located away from critical structures.<ref name="pmid17695387">{{cite journal | vauthors = Kollová A, Liscák R, Novotný J, Vladyka V, Simonová G, Janousková L | title = Gamma Knife surgery for benign meningioma | journal = Journal of Neurosurgery | volume = 107 | issue = 2 | pages = 325–336 | date = August 2007 | pmid = 17695387 | doi = 10.3171/JNS-07/08/0325 }}</ref> Fractionated external-beam radiation also can be used as primary treatment for tumors that are surgically unresectable or, for patients who are inoperable for medical reasons.{{citation needed|date=July 2021}}
Radiation therapy often is considered for WHO grade I meningiomas after subtotal (incomplete) tumor resections. The clinical decision to irradiate after a subtotal resection is somewhat controversial, as no class I randomized, controlled trials exist on the subject.<ref name="pmid3403313">{{cite journal | vauthors = Taylor BW, Marcus RB, Friedman WA, Ballinger WE, Million RR | title = The meningioma controversy: postoperative radiation therapy | journal = International Journal of Radiation Oncology, Biology, Physics | volume = 15 | issue = 2 | pages = 299–304 | date = August 1988 | pmid = 3403313 | doi = 10.1016/S0360-3016(98)90008-6 }}</ref> Numerous retrospective studies, however, have suggested strongly that the addition of postoperative radiation to incomplete resections improves both progression-free survival (i.e. prevents tumor recurrence) and improves overall survival.<ref>{{cite journal | vauthors = Goldsmith BJ, Wara WM, Wilson CB, Larson DA | title = Postoperative irradiation for subtotally resected meningiomas. A retrospective analysis of 140 patients treated from 1967 to 1990 | journal = Journal of Neurosurgery | volume = 80 | issue = 2 | pages = 195–201 | date = February 1994 | pmid = 8283256 | doi = 10.3171/jns.1994.80.2.0195 }}</ref>
In the case of a grade III meningioma, the current standard of care involves postoperative radiation treatment regardless of the degree of surgical resection.<ref name="pmid10656373">{{cite journal | vauthors = Goyal LK, Suh JH, Mohan DS, Prayson RA, Lee J, Barnett GH | title = Local control and overall survival in atypical meningioma: a retrospective study | journal = International Journal of Radiation Oncology, Biology, Physics | volume = 46 | issue = 1 | pages = 57–61 | date = January 2000 | pmid = 10656373 | doi = 10.1016/S0360-3016(99)00349-1 | doi-access = free }}</ref> This is due to the proportionally higher rate of local recurrence for these higher-grade tumors. Grade II tumors may behave variably and there is no standard of whether to give radiotherapy following a gross total resection. Subtotally resected grade II tumors should be radiated.{{citation needed|date=July 2021}}
===Chemotherapy=== Likely, current chemotherapies are not effective. Antiprogestin agents have been used, but with variable results.<ref name="pmid15006250">{{cite journal | vauthors = Wahab M, Al-Azzawi F | title = Meningioma and hormonal influences | journal = Climacteric | volume = 6 | issue = 4 | pages = 285–292 | date = December 2003 | pmid = 15006250 | doi = 10.1080/cmt.6.4.285.292 | s2cid = 27776126 }}</ref> A 2007 study of whether hydroxyurea has the capacity to shrink unresectable or recurrent meningiomas is being further evaluated.<ref>{{cite journal | vauthors = Newton HB | title = Hydroxyurea chemotherapy in the treatment of meningiomas | journal = Neurosurgical Focus | volume = 23 | issue = 4 | article-number = E11 | year = 2007 | pmid = 17961035 | doi = 10.3171/foc-07/10/e11 | doi-access = free }}</ref>
==Epidemiology== Many individuals have meningiomas, but remain asymptomatic, so the meningiomas are discovered during an autopsy. One to two percent of all autopsies reveal meningiomas that were unknown to the individuals during their lifetime, since there were never any symptoms. In the 1970s, tumors causing symptoms were discovered in 2 out of 100,000 people, while tumors discovered without causing symptoms occurred in 5.7 out of 100,000, for a total incidence of 7.7/100,000. With the advent of modern sophisticated imaging systems such as CT scans, the discovery of asymptomatic meningiomas has tripled.{{citation needed|date=July 2021}}
Meningiomas are more likely to appear in women than men, though when they appear in men, they are more likely to be malignant. Meningiomas may appear at any age, but most commonly are noticed in men and women age 50 or older, with meningiomas becoming more likely with age. They have been observed in all cultures, Western and Eastern, in roughly the same statistical frequency as other possible brain tumors.<ref name=Lee2008/>
==History== The neoplasms currently referred to as meningiomas were referred to with a wide range of names in older medical literature, depending on the source. Various descriptors included "fungoid tumors", "fungus of the dura mater", "epithelioma", "psammoma", "dural sarcoma", "dural endothelioma", "fibrosarcoma", "angioendothelioma", "arachnoidal fibroboastoma", "endotheliosis of the meninges", "meningeal fibroblastoma", "meningoblastoma", "mesothelioma of the meninges", "sarcoma of the dura", and others.{{citation needed|date=July 2021}}
The modern term "meningioma" was used first by Harvey Cushing (1869–1939) in 1922, to describe a set of tumors that occur throughout the neuraxis (brain and spinal cord), but have various commonalities.<ref name="OkonkwoLaws2009">{{Cite book|vauthors =Okonkwo DO, Laws ER|year=2009|pages=3–10|doi=10.1007/978-1-84628-784-8_1|title =Meningiomas|isbn =978-1-84882-910-7|chapter =Meningiomas: Historical Perspective}}</ref><ref name="Prayson2009">{{Cite book|vauthors =Prayson RA|year=2009|pages=31–43|doi=10.1007/978-1-84628-784-8_5|title =Meningiomas|isbn =978-1-84882-910-7|chapter =Pathology of Meningiomas}}</ref> Charles Oberling then separated these into subtypes based on cell structure and, over the years, several other researchers have defined dozens of different subtypes as well. In 1979, the World Health Organization (WHO) classified seven subtypes, upgraded in 2000 to a classification system with nine low-grade variants (grade I tumors) and three variants each of grade II and grade III meningiomas.<ref name="Prayson2009"/> The most common subtypes are Meningotheliomatous (63%), transitional or mixed-type (19%), fibrous (13%), and psammomatous (2%).<ref name=Lee2008/>
The earliest evidence of a probable meningioma is from a skull approximately 365,000 years old, which was found in Germany. Other probable examples have been discovered in other continents around the world, including North and South America, and Africa.{{citation needed|date=October 2021}}
The earliest written record of what was probably a meningioma is from the 1600s, when Felix Plater (1536–1614) of the University of Basel performed an autopsy on Sir Caspar Bonecurtius.<ref name="OkonkwoLaws2009"/> Surgery for removal of a meningioma was first attempted in the sixteenth century, but the first known successful surgery for removal of a meningioma of the convexity (parasagittal) was performed in 1770 by Anoine Luis.<ref>{{cite journal | vauthors = Louis A | year = 1774 | title = Mêmoire sur les Tumeurs Fungueuses de la Dure-mère | journal = Mem Acad Roy Chir | volume = 5 | pages = 1–59 }}</ref> The first documented successful removal of a skull base meningioma was performed in 1835 by Zanobi Pecchioli, Professor of Surgery at the University of Siena.<ref name=Lee2008/> Other notable meningioma researchers have been William Macewen (1848–1924), and William W. Keen (1837–1932).<ref name="OkonkwoLaws2009"/>
Improvements in meningioma research and treatment over the last century have occurred in terms of the surgical techniques for removal of the tumor, and related improvements in anesthesia, antiseptic methods, techniques to control blood loss, better ability to determine which tumors are and are not operable,<ref>{{Cite book| publisher = Thieme| isbn = 978-1-60406-053-9| vauthors = DeMonte F, Al-Mefty O, McDermott M | title = Al-Mefty's Meningiomata| edition=2nd|year = 2011}}</ref> and to effectively differentiate between the different meningioma subtypes.<ref>{{cite journal | vauthors = Al-Kadi OS | title = A multiresolution clinical decision support system based on fractal model design for classification of histological brain tumours | journal = Computerized Medical Imaging and Graphics | volume = 41 | pages = 67–79 | date = April 2015 | pmid = 24962336 | doi = 10.1016/j.compmedimag.2014.05.013 | arxiv = 1512.08051 | s2cid = 2518941 }}</ref>
==Notable cases== * Leonard Wood (1860–1927), underwent successful surgery by Dr. Harvey Cushing for a meningioma circa 1910, a major advance in neurosurgery at the time.<ref name="OkonkwoLaws2009"/> * Crystal Lee Sutton (1940–2009), American union organizer and inspiration for the film ''Norma Rae'', died of a malignant meningioma.<ref name="insurer_delay_timesnews">{{cite news|url=http://www.thetimesnews.com/news/rapids-15070-sutton-roanoke.html|title=Real 'Norma Rae' has new battle involving cancer|work=The Times-News|date=2008-06-28| vauthors = Handgraaf B |archive-url=https://web.archive.org/web/20120302231039/http://www.thetimesnews.com/news/rapids-15070-sutton-roanoke.html|archive-date=2012-03-02|access-date=2012-02-25}}</ref><ref>{{cite news|url=http://www.southernstudies.org/2009/09/real-norma-rae-dies-of-cancer-after-insurer-delayed-treatment.html|title=Real 'Norma Rae' dies of cancer after insurer delayed treatment|work=Facing South|publisher=Institute for Southern Studies|date=2009-09-14| vauthors = Sturgis S |archive-url=https://web.archive.org/web/20131027002233/http://www.southernstudies.org/2009/09/real-norma-rae-dies-of-cancer-after-insurer-delayed-treatment.html|archive-date=2013-10-27|access-date=2012-02-25}}</ref> * Elizabeth Taylor (1932–2011), American actress, underwent surgery in February 1997 to remove a benign meningioma.<ref>{{cite news|url=http://edition.cnn.com/SHOWBIZ/9702/26/liz.taylor/|archive-url=https://web.archive.org/web/20190101051736/http://edition.cnn.com/SHOWBIZ/9702/26/liz.taylor/|archive-date=January 1, 2019|title=Elizabeth Taylor home from hospital after brain surgery|work=CNN News|date=February 26, 1997|access-date=2018-12-31}}</ref> * Kathi Goertzen (1958–2012), television news anchor in Seattle who underwent a very public battle with recurring tumors. She died on August 13, 2012, of complications related to her treatment.<ref>{{cite web|url=http://www.king5.com/story/news/2014/08/03/13150826/|title=News anchor Kathi Goertzen dies after long illness|author=Staff|publisher=CBS-Channel 5 KING|date=February 6, 2013|access-date=March 5, 2015|archive-url=https://web.archive.org/web/20150403073955/http://www.king5.com/story/news/2014/08/03/13150826/|archive-date=April 3, 2015}}</ref> * Eileen Ford (1922–2014), American model agency executive and co-founder of Ford Models. Died on July 9, 2014, from complications of meningioma and osteoporosis.<ref>[http://www.cnn.com/2014/07/10/showbiz/eileen-ford-obit/index.html Notice of death of Eileen Ford, with causes provided] {{webarchive|url=https://web.archive.org/web/20140713005808/http://www.cnn.com/2014/07/10/showbiz/eileen-ford-obit/index.html |date=2014-07-13 }}, CNN.com, July 10, 2014; accessed July 13, 2014.</ref> * Mary Tyler Moore (1936–2017), American actress, underwent surgery in May 2011 to remove a benign meningioma.<ref>{{cite news|url=https://abcnews.go.com/Health/mary-tyler-moore-undergoes-brain-surgery-meningioma-tumor/story?id=13589156|title=Mary Tyler Moore has brain surgery for meningioma tumor|work=ABC News|date=May 12, 2011| vauthors = Goldman R |access-date=2012-02-25|url-status=live|archive-url=https://web.archive.org/web/20120221002433/https://abcnews.go.com/Health/mary-tyler-moore-undergoes-brain-surgery-meningioma-tumor/story?id=13589156#.T0lWBXnubL8|archive-date=February 21, 2012}}</ref><ref>{{cite news|title=Boy, did she make it|work=The New York Times|date=January 26, 2012| vauthors = Genzlinger N |access-date=February 25, 2012|url=https://www.nytimes.com/2012/01/27/arts/television/mary-tyler-moore-to-receive-screen-actors-guild-award.html|url-status=live|archive-url=https://web.archive.org/web/20120215142805/http://www.nytimes.com/2012/01/27/arts/television/mary-tyler-moore-to-receive-screen-actors-guild-award.html|archive-date=February 15, 2012}}</ref> * Jack Daulton (1956–), American trial lawyer and art collector, underwent three surgeries in 2011–2012 in connection with the removal of a golf-ball-size benign meningioma over his left motor cortex; he fully recovered without disability or recurrence.<ref>{{cite web | title = Jack Daulton's Brain Surgery Saga, final chapter (cranioplasty after meningioma tumor removal) | url = https://www.youtube.com/watch?v=Bljirn0Gkyc&t=57s | work = YouTube | date = 10 April 2012 }}</ref> * Simone Giertz (1990–), Swedish inventor and professional YouTuber, underwent surgery to remove a grade I meningioma in 2018 and radiation therapy after tumor regrowth in 2019.
== References == {{Reflist}}
== External links == * [https://web.archive.org/web/20120205092841/http://rad.usuhs.edu/medpix/medpix.html?mode=image_finder&srchstr=meningioma&srch_type=all&action=search#top MR/CT scans of meningioma] from MedPix * [https://archive.today/20121215050825/http://rad.usuhs.edu/medpix/raw_image.html?mode=cow_viewer&pt_id=13349&imid=51843 MR/CT scans of pneumosinus dilatans] from MedPix * [https://www.cancer.net/cancer-types/meningioma Cancer.Net: Meningioma]
{{Nervous tissue tumors}} {{Medical resources | DiseasesDB = 8008 | ICD10 = {{ICD10|C|70||c|70}}, {{ICD10|D|32||d|32}} | ICD9 = {{ICD9|225.2}} | ICDO = {{ICDO|9530|0}} | OMIM = 607174 | MedlinePlus = | eMedicineSubj = neuro | eMedicineTopic = 209 | eMedicine_mult = {{eMedicine2|radio|439}} | MeshID = D008579 }} {{Authority control}}
Category:Brain tumor Category:Nervous system neoplasia Category:Wikipedia medicine articles ready to translate