Psammoma body

{{short description|Microscopic nodule of calcium in the body}} [[File:Meningioma showing Psammoma body.jpg|thumbnail|Micrograph of psammoma body in the centre of the field in a meningioma of brain. H&E stain.]]

A '''psammoma body''' is a round collection of calcium, seen microscopically. The term is derived {{ety|el|''άμμος'' (ámmos)|sand}}.

==Cause== Psammoma bodies are associated with the papillary (nipple-like) histo morphology and are thought to arise from, # Infarction and calcification of papillae tips. # Calcification of intralymphatic tumor thrombi.<ref>{{cite journal |vauthors=Johannessen JV, Sobrinho-Simões M |title=The origin and significance of thyroid psammoma bodies |journal=Lab. Invest. |volume=43 |issue=3 |pages=287–96 |date=September 1980 |pmid=7401638 }}</ref>

==Association with lesions== Psammoma bodies are commonly seen in certain tumors such as: * Papillary thyroid carcinoma<ref>Chapter 20 in: {{cite book |author1=Mitchell, Richard Sheppard |author2=Kumar, Vinay |author3=Abbas, Abul K |author4=Fausto, Nelson |title=Robbins Basic Pathology|publisher=Saunders |location=Philadelphia |year= 2007|isbn=978-1-4160-2973-1 }} 8th edition.</ref> * Papillary renal cell carcinoma<ref>{{cite web |url= https://www.lecturio.com/concepts/renal-cell-carcinoma/| title= Renal Cell Carcinoma|website=The Lecturio Medical Concept Library |access-date= 1 October 2021}}</ref> * Ovarian papillary serous cystadenoma and cystadenocarcinoma<ref>[http://library.med.utah.edu/WebPath/FEMHTML/FEM072.html Ovarian papillary serous cystadenocarcinoma] at [http://library.med.utah.edu/WebPath/ WebPath], The Internet Pathology Laboratory for Medical Education at Mercer University School of Medicine. Retrieved July 2011</ref> * Endometrial adenocarcinomas (papillary serous carcinoma ~3%-4%) * Meningiomas, in the central nervous system<ref>{{cite web |url=http://spinwarp.ucsd.edu/neuroweb/Text/br-300b.htm |url-status=dead |archive-url=https://web.archive.org/web/20000301035114/http://spinwarp.ucsd.edu/NeuroWeb/Text/br-300b.htm |archive-date=2000-03-01 |title=Brain Stem & Posterior Fossa}}</ref> * Peritoneal and pleural mesothelioma * Somatostatinoma (pancreas)<ref>{{cite journal | doi = 10.1148/rg.306105523 | volume=30 | title=Pancreatic Endocrine Tumors: Radiologic-Clinicopathologic Correlation | journal=RadioGraphics | pages=1445–1464 | year=2010 | author=Lewis RB| issue=6 | pmid=21071369 }}</ref> * Prolactinoma of the pituitary <ref>Robbin's Pathology, Eight Ed</ref> *Glucagonoma<ref>{{cite web |url= https://www.lecturio.com/concepts/glucagonoma/| title= Glucagonoma |website=The Lecturio Medical Concept Library |access-date= 1 October 2021}}</ref> * Micropapillary subtype of lung adenocarcinoma<ref>{{cite journal | pmid = 31352072 | doi=10.1016/j.jtho.2019.07.008 | volume=14 | title=Expansion of the Concept of Micropapillary Adenocarcinoma to Include a Newly Recognized Filigree Pattern as Well as the Classical Pattern Based on 1468 Stage I Lung Adenocarcinomas | year=2019 | author=Emoto K, Eguchi T, Tan KS, Takahashi Y, Aly RG, Rekhtman N, Travis WD, Adusumilli PS | journal=J Thorac Oncol | issue=11 | pages=1948–1961| pmc=8785415 | doi-access=free }}</ref>

==Benign lesions== [[Image:Psammomatous_melanotic_schwannoma_-_very_high_mag.jpg|thumb|right|150px|Micrograph of a psammomatous melanotic schwannoma with a psammoma body, as may be seen in Carney complex. H&E stain.]] Psammoma bodies may be seen in: * Endosalpingiosis<ref name=pmid1774734>{{cite journal |vauthors=Hallman KB, Nahhas WA, Connelly PJ |title=Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report |journal=J Reprod Med |volume=36 |issue=9 |pages=675–8 |date=September 1991 |pmid=1774734 }}</ref> * Psammomatous melanotic schwannoma * Melanocytic nevus<ref>Rapini, Ronald. ''Practical Dermatopathology''. Elsevier Mosby, 2005, p. 10.</ref>

==Appearance== Psammoma bodies usually have a laminar appearance, are circular, acellular and basophilic.

==References== {{Reflist|2}}

==External links== {{wiktionary|papillary}} Slides: * [https://archive.today/20020123120030/http://bl-msci-007c.ads.iu.edu/c602web/602/c602web/cns/sl38_1.htm Meningioma] * [https://web.archive.org/web/20060110184326/http://cpmcnet.columbia.edu/dept/thyroid/papillary.html Thyroid cancer] * [http://www.memfert.com/laels91/laels%2038.jpg Endometriosis (peritoneum)] * [https://www.youtube.com/watch?v=ddEB5ITx2fw Video of psammoma bodies in meningioma]

Category:Histopathology