{{Short description|Insufficient production of steroid hormones by the adrenal glands}} {{About|medically-recognized chronic adrenal insufficiency|a term used in alternative medicine|Adrenal fatigue}} {{Infobox medical condition (new) | name = Adrenal insufficiency | synonyms = adrenocortical insufficiency, hypocorticalism, hypocortisolism, hypoadrenocorticism, hypocorticism, hypoadrenalism | image = Illu adrenal gland.jpg | caption = Adrenal gland | field = Endocrinology | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}
'''Adrenal insufficiency''' is a condition in which the adrenal glands do not produce adequate amounts of steroid hormones. The adrenal glands—also referred to as the adrenal cortex—normally secrete glucocorticoids (primarily cortisol), mineralocorticoids (primarily aldosterone), and androgens.<ref name="ch164b.html">{{cite journal |author=Ashley B. Grossman, MD |year=2007 |title=Addison's Disease |url=http://www.merck.com/mmhe/sec13/ch164/ch164b.html |journal=Adrenal Gland Disorders}}</ref><ref name=":0">{{Citation |last1=Nicolaides |first1=Nicolas C. |title=Adrenal Insufficiency |date=2000 |url=https://www.ncbi.nlm.nih.gov/books/NBK279083/ |work=Endotext |editor-last=Feingold |editor-first=Kenneth R. |place=South Dartmouth (MA) |publisher=MDText.com, Inc. |pmid=25905309 |access-date=2022-11-02 |last2=Chrousos |first2=George P. |last3=Charmandari |first3=Evangelia |editor2-last=Anawalt |editor2-first=Bradley |editor3-last=Boyce |editor3-first=Alison |editor4-last=Chrousos |editor4-first=George}}</ref><ref name=":1">{{Citation |last1=Huecker |first1=Martin R. |title=Adrenal Insufficiency |date=2022 |url=https://www.ncbi.nlm.nih.gov/books/NBK441832/ |work=StatPearls |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=28722862 |access-date=2022-11-02 |last2=Bhutta |first2=Beenish S. |last3=Dominique |first3=Elvita}}</ref><ref>{{Cite journal |last1=Bancos |first1=Irina |last2=Hahner |first2=Stefanie |last3=Tomlinson |first3=Jeremy |last4=Arlt |first4=Wiebke |date=2015-03-01 |title=Diagnosis and management of adrenal insufficiency |url=https://doi.org/10.1016/S2213-8587(14)70142-1 |journal=The Lancet Diabetes & Endocrinology |volume=3 |issue=3 |pages=216–226 |doi=10.1016/s2213-8587(14)70142-1 |pmid=25098712 |issn=2213-8587|url-access=subscription }}</ref> These hormones are important in regulating blood pressure, electrolytes, and metabolism as a whole.<ref name=":0" /><ref name=":1" /> Deficiency of these hormones leads to symptoms ranging from abdominal pain, vomiting, muscle weakness and fatigue, low blood pressure, depression, mood and personality changes (in mild cases) to organ failure and shock (in severe cases).<ref name="ch164b.html" /><ref name=":0" /><ref name=":1" /> Adrenal crisis may occur if a person having adrenal insufficiency experiences stresses, such as an accident, injury, surgery, or severe infection; this is a life-threatening medical condition resulting from severe deficiency of cortisol in the body.<ref name=":0" /><ref name=":1" /> Death may quickly follow.<ref name="ch164b.html" />
Adrenal insufficiency can be caused by dysfunction of the adrenal gland itself, whether by destruction (e.g., Addison's disease), failure of development (e.g., adrenal dysgenesis), or enzyme deficiency (e.g., congenital adrenal hyperplasia).<ref name=":0" /><ref name=":1" /> Adrenal insufficiency can also occur when the pituitary gland or the hypothalamus do not produce adequate amounts of the hormones that assist in regulating adrenal function.<ref name="addisons_disease.aspx">{{cite journal |author=Eileen K. Corrigan |year=2007 |title=Adrenal Insufficiency (Secondary Addison's or Addison's Disease) |url=http://www.pituitary.org/disorders/addisons_disease.aspx |journal=NIH Publication No. 90-3054 |access-date=2008-08-22 |archive-date=2008-09-15 |archive-url=https://web.archive.org/web/20080915172708/http://www.pituitary.org/disorders/addisons_disease.aspx |url-status=dead }}</ref><ref name="urlJAMA -- Adrenal Insufficiency, November 16, 2005, Brender et al. 294 (19): 2528">{{cite journal |vauthors=Brender E, Lynm C, Glass RM |title=JAMA patient page. Adrenal insufficiency |journal=JAMA |volume=294 |issue=19 |page=2528 |year=2005 |pmid=16287965 |doi=10.1001/jama.294.19.2528 |doi-access=free }}</ref><ref name="urlDorlands Medical Dictionary: adrenal insufficiency">{{cite web |url=http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/four/000053970.htm |title=Dorlands Medical Dictionary: adrenal insufficiency }}</ref> This is called secondary adrenal insufficiency (when caused by lack of production of adrenocorticotropic hormone (ACTH) in the pituitary gland) or tertiary adrenal insufficiency (when caused by lack of corticotropin-releasing hormone (CRH) in the hypothalamus).<ref name=":0" /><ref name=":1" /><ref name="urlSecondary Adrenal Insufficiency: Adrenal Disorders: Merck Manual Professional">{{Cite web |title=Secondary Adrenal Insufficiency - Endocrine and Metabolic Disorders |url=https://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/adrenal-disorders/secondary-adrenal-insufficiency |website=Merck Manuals Professional Edition}}</ref>
==Types== There are three major types of adrenal insufficiency, depending on the affected organ. * '''Primary adrenal insufficiency''' is due to impairment of the adrenal glands, resulting in a lack of glucocorticoid production. Since the adrenal glands are directly affected, mineralocorticoid production is also reduced. Principal causes include: ** Autoimmune: e.g., Addison's disease (also called autoimmune adrenalitis), which has been identified to be the cause of 80–90% of primary adrenal insufficiency cases since 1950.<ref name=":0" /> ** Congenital: e.g. congenital adrenal hyperplasia, adrenoleukodystrophy<ref name=":0" /> ** Infection: e.g. tuberculosis, CMV, histoplasmosis<ref name=":0" /> ** Drugs: e.g. anticonvulsants, etomidate, metyrapone, rifampicin<ref name=":0" /> ** Vascular: e.g. hemorrhage from sepsis, adrenal vein thrombosis, hypercoagulable states such as heparin-induced thrombocytopenia and antiphospholipid syndrome<ref name=":0" /> ** Neoplasia: e.g. adenoma (tumor) of the adrenal gland<ref name=":0" /> ** Deposition disease: e.g. hemochromatosis, amyloidosis, sarcoidosis<ref name=":0" /> ** Idiopathic: undetermined cause ** Acquired: Bilateral Adrenalectomy to treat recurrent Cushing's Disease/Syndrome * '''Secondary adrenal insufficiency''' is caused by impairment of the pituitary gland, resulting in a lack of adrenocorticotropic hormone (ACTH) production and subsequent decreased adrenal stimulation. Since the adrenal glands are not directly affected, the effect on mineralocorticoid production is minimal, as ACTH primarily affects glucocorticoid production.<ref name=":0" /><ref name=":1" /> Principal causes include: ** Pituitary adenoma or craniopharyngioma: Tumors in the pituitary gland can suppress production of adrenocorticotropic hormone (ACTH).<ref name=":0" /> High-dose irradiation (>30 Gy) to the hypothalamus or the pituitary gland can cause ACTH deficiency.<ref>{{cite journal |last1=Sklar |first1=CA |last2=Antal |first2=Z |last3=Chemaitilly |first3=W |last4=Cohen |first4=LE |last5=Follin |first5=C |last6=Meacham |first6=LR |last7=Murad |first7=MH |title=Hypothalamic-Pituitary and Growth Disorders in Survivors of Childhood Cancer: An Endocrine Society Clinical Practice Guideline. |journal=The Journal of Clinical Endocrinology and Metabolism |date=1 August 2018 |volume=103 |issue=8 |pages=2761–2784 |doi=10.1210/jc.2018-01175 |pmid=29982476|s2cid=51601915 |doi-access=free }}</ref> ** Surgery or radiation: Pituitary gland surgery and/or radiation can lead to destruction of ACTH-producing tissue.<ref name=":0" /> ** Exogenous corticosteroid use: Exogenous corticosteroids suppress the stimulation of the hypothalamus and the pituitary gland to secrete CRH and ACTH, respectively.<ref name=":0" /><ref name=":1" /> These cases may present with symptoms of cortisol excess (see Cushing's syndrome).<ref name=":1" /> ** Sheehan's syndrome: Loss of blood flow to the pituitary gland following childbirth<ref name=":0" /> ** Pituitary apoplexy: Bleeding or impaired blood supply to the pituitary gland<ref name=":0" /> * '''Tertiary adrenal insufficiency''' is caused by impairment of the hypothalamus, resulting in a lack of corticotropin-releasing hormone (CRH) production, causing downstream reduction in ACTH production and subsequently decreasing adrenal stimulation.<ref name=":0" /> Since the adrenal glands are not directly affected, the effect on mineralocorticoid production is minimal, as ACTH primarily affects glucocorticoid production.<ref name=":0" /><ref name=":1" /> Principal causes include: ** Sudden withdrawal from long-term exogenous steroid use<ref name=":0" /><ref name=":1" /> ** Brain tumors<ref name=":0" /><ref name=":1" />
==Signs and symptoms== Signs and symptoms include: hypoglycemia, hyperpigmentation, dehydration, weight loss, and disorientation. Additional signs and symptoms include weakness, tiredness, dizziness, low blood pressure that falls further when standing (orthostatic hypotension), cardiovascular collapse, muscle aches, nausea, vomiting, and diarrhea. These problems may develop gradually and insidiously. Addison's disease can present with tanning of the skin that may be patchy or even all over the body. Characteristic sites of tanning are skin creases (e.g., of the hands) and the inside of the cheek (buccal mucosa). Goitre and vitiligo may also be present.<ref name="ch164b.html"/> Eosinophilia may also occur.<ref name="pmid23368869">{{cite journal | vauthors = Montgomery ND, Dunphy CH, Mooberry M, Laramore A, Foster MC, Park SI, Fedoriw YD | s2cid = 17918640 | title = Diagnostic complexities of eosinophilia | journal = Archives of Pathology & Laboratory Medicine | volume = 137 | issue = 2 | pages = 259–69 | year = 2013 | pmid = 23368869 | doi = 10.5858/arpa.2011-0597-RA | url = http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2011-0597-RA | url-access = subscription }}</ref> Hyponatremia is a sign of secondary insufficiency.<ref>{{cite journal |last1=Jessani |first1=Naureen |last2=Jehangir |first2=Waqas |last3=Behman |first3=Daisy |last4=Yousif |first4=Abdalla |last5=Spiler |first5=Ira J. |title=Secondary Adrenal Insufficiency: An Overlooked Cause of Hyponatremia |journal=Journal of Clinical Medicine Research |date=April 2015 |volume=7 |issue=4 |pages=286–288 |doi=10.14740/jocmr2041w |pmid=25699130 |pmc=4330026 }}</ref>
==Pathophysiology== thumb|660x660px|Diagram detailing the hypothalamus–pituitary–adrenal axis in the normal state, primary adrenal insufficiency, secondary adrenal insufficiency, and tertiary adrenal insufficiency thumb|The adrenal cortex produces different hormones in different areas of the organs, called ''zonas''.
When functioning normally, the adrenal glands secrete glucocorticoids (primarily cortisol) in the ''zona fasciculata'' and mineralocorticoids (primarily aldosterone) in the ''zona glomerulosa'' to regulate metabolism, blood pressure, and electrolyte balance.<ref name=":2">{{Citation |last1=Thau |first1=Lauren |title=Physiology, Cortisol |date=2022 |url=https://www.ncbi.nlm.nih.gov/books/NBK538239/ |work=StatPearls |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=30855827 |access-date=2022-11-08 |last2=Gandhi |first2=Jayashree |last3=Sharma |first3=Sandeep}}</ref> Adrenal hormone production is controlled by the hypothalamic–pituitary–adrenal axis, in which the hypothalamus produces corticotropin-releasing hormone (CRH), which stimulates the pituitary gland to produce adrenocorticotropic hormone (ACTH), which stimulates the adrenal gland to produce cortisol.<ref name=":2" /> High levels of cortisol inhibit the production of both CRH and ACTH, forming a negative feedback loop.<ref name=":2" /> The types of adrenal insufficiency thus refer to the level of the axis in which the dysfunction originates: primary, secondary, and tertiary for adrenal glands, pituitary gland, and hypothalamus, respectively.<ref name=":0" /><ref name=":1" />
In adrenal insufficiency, cortisol production is deficient, which may be accompanied by a deficiency in aldosterone production (predominantly in primary adrenal insufficiency).<ref name=":0" /><ref name=":1" /> Depending on the cause and type of adrenal insufficiency, the mechanism of the disease differs. Generally, the symptoms manifest through the systemic effects of cortisol and aldosterone.<ref name=":0" /><ref name=":1" /> In secondary and tertiary adrenal insufficiency, there is no effect on the production of aldosterone within the ''zona glomerulosa'' as this process is regulated by the renin–angiotensin–aldosterone system (RAAS), not ACTH.<ref name=":1" />
Adrenal insufficiency can also affect the ''zona reticularis'' and disrupt production of androgens, which are precursors to testosterone and estrogen.<ref name=":0" /><ref name=":1" /> This leads to a deficiency of sex hormones and can contribute to symptoms of depression and menstrual irregularities.<ref name=":0" /><ref name=":1" />
=== Cortisol deficiency === Cortisol increases blood sugar by inducing gluconeogenesis (glucose production) in the liver, lipolysis (fat breakdown) in adipose tissue, and proteolysis (muscle breakdown) in muscle while increasing glucagon secretion and decreasing insulin secretion in the pancreas.<ref name=":2" /> Overall, these actions cause the body to use fat stores and muscle for energy. Deficiency results in hypoglycemia, with associated nausea, vomiting, fatigue, and weakness.<ref name=":0" />
Cortisol potentiates the effectiveness of angiotensin II and catecholamines such as norepinephrine in vasoconstriction. Thus, a deficiency can contribute to hypotension, though this effect is most pronounced in mineralocorticoid deficiency.<ref name=":0" />
In primary adrenal insufficiency, the lack of negative feedback from cortisol leads to increased production of CRH and ACTH.<ref name=":0" /><ref name=":1" /> ACTH is derived from pro-opiomelanocortin (POMC), which is cleaved into ACTH as well as α-MSH, which regulates production of melanin in the skin.<ref>{{Cite journal |last1=Videira |first1=Inês Ferreira dos Santos |last2=Moura |first2=Daniel Filipe Lima |last3=Magina |first3=Sofia |date=2013 |title=Mechanisms regulating melanogenesis |journal=Anais Brasileiros de Dermatologia |volume=88 |issue=1 |pages=76–83 |doi=10.1590/S0365-05962013000100009 |issn=0365-0596 |pmc=3699939 |pmid=23539007}}</ref> The overproduction of α-MSH leads to the characteristic hyperpigmentation of Addison's disease.<ref>{{Cite journal |last1=Nieman |first1=Lynnette K. |last2=Chanco Turner |first2=Maria L. |date=July–August 2006 |title=Addison's disease |journal=Clinics in Dermatology |volume=24 |issue=4 |pages=276–280 |doi=10.1016/j.clindermatol.2006.04.006 |issn=0738-081X |pmid=16828409}}</ref>
=== Aldosterone deficiency === Although the production of aldosterone occurs within the adrenal cortex, it is not induced by adrenocorticotropic (ACTH); instead, it is regulated by the renin–angiotensin–aldosterone system (RAAS).<ref name=":3">{{Citation |last1=Arai |first1=Keiko |title=Aldosterone Deficiency and Resistance |date=2000 |url=https://www.ncbi.nlm.nih.gov/books/NBK279079/ |work=Endotext |editor-last=Feingold |editor-first=Kenneth R. |place=South Dartmouth (MA) |publisher=MDText.com, Inc. |pmid=25905305 |access-date=2022-11-08 |last2=Papadopoulou-Marketou |first2=Nektaria |last3=Chrousos |first3=George P. |editor2-last=Anawalt |editor2-first=Bradley |editor3-last=Boyce |editor3-first=Alison |editor4-last=Chrousos |editor4-first=George}}</ref> Renin production in the juxtaglomerular cells of the kidney is induced by decreased arterial blood pressure, decreased sodium content in the distal convoluted tubule, and increased sympathetic tone.<ref name=":3" /> Renin initiates the downstream sequence of cleavage of angiotensinogen to angiotensin I to angiotensin II, in which angiotensin II stimulates aldosterone production in the ''zona glomerulosa''.<ref name=":3" /> Thus, dysfunction of the pituitary gland or the hypothalamus does not affect the production of aldosterone.<ref name=":0" /><ref name=":1" /> However, in primary adrenal insufficiency, damage to the adrenal cortex (e.g. autoimmune adrenalitis a.k.a. Addison's disease) can lead to destruction of the ''zona glomerulosa'' and therefore a loss of aldosterone production.
Aldosterone acts on mineralocorticoid receptors on epithelial cells lining the distal convoluted tubule, activating epithelial sodium channels (ENaC) and the Na⁺/K⁺-ATPase pump.<ref name=":3" /> This results in the absorption of sodium (with resulting retention of fluid) and the excretion of potassium.<ref name=":3" /> Deficiency of aldosterone leads to urinary loss of sodium and effective circulating volume, as well as retention of potassium.<ref name=":3" /> This can cause hypotension (in severe cases, shock), dizziness (from orthostatic hypotension), dehydration, and salt craving. {{cn|date=March 2025}}
Unlike mineralocorticoid deficiency, glucocorticoid deficiency does not cause a negative sodium balance (in fact, a positive sodium balance may occur).<ref>{{cite journal |last1=Schrier |first1=R. W. |year=2006 |title=Body Water Homeostasis: Clinical Disorders of Urinary Dilution and Concentration |journal=Journal of the American Society of Nephrology |volume=17 |issue=7 |pages=1820–32 |doi=10.1681/ASN.2006030240 |pmid=16738014 |doi-access=free}}</ref>
== Causes == Causes of acute adrenal insufficiency are mainly sudden withdrawal of long-term corticosteroid therapy, Waterhouse–Friderichsen syndrome, and stress in people with underlying chronic adrenal insufficiency.<ref name=Robbins20-7>Table 20-7 in: {{cite book |author1=Mitchell, Richard Sheppard |author2=Kumar, Vinay |author3=Abbas, Abul K. |author4=Fausto, Nelson |title=Robbins Basic Pathology|publisher=Saunders |location=Philadelphia |year= 2007|isbn=978-1-4160-2973-1 }} 8th edition.</ref> The latter is termed critical illness–related corticosteroid insufficiency.<ref>{{Cite journal |last1=Téblick |first1=Arno |last2=Gunst |first2=Jan |last3=Van den Berghe |first3=Greet |date=2022-06-16 |title=Critical Illness-induced Corticosteroid Insufficiency: What It Is Not and What It Could Be |journal=The Journal of Clinical Endocrinology and Metabolism |volume=107 |issue=7 |pages=2057–2064 |doi=10.1210/clinem/dgac201 |issn=1945-7197 |pmc=9202732 |pmid=35358303}}</ref>
For chronic adrenal insufficiency, the major contributors are autoimmune adrenalitis (Addison's Disease), tuberculosis, AIDS, and metastatic disease.<ref name=Robbins20-7/> Minor causes of chronic adrenal insufficiency are systemic amyloidosis, fungal infections, hemochromatosis, and sarcoidosis.<ref name=Robbins20-7/>
Causes of adrenal insufficiency can be categorized by the mechanism through which they cause the adrenal glands to produce insufficient cortisol. These are adrenal destruction (disease processes leading to glandular damage), impaired steroidogenesis (the gland is present but is biochemically unable to produce cortisol), or adrenal dysgenesis (the gland has not formed adequately during development).<ref name="Ten">{{cite journal |last1=Ten |first1=Svetlana |last2=New |first2=Maria |last3=Maclaren |first3=Noel |title=Addison's Disease 2001 |journal=The Journal of Clinical Endocrinology & Metabolism |date=July 2001 |volume=86 |issue=7 |pages=2909–2922 |doi=10.1210/jcem.86.7.7636 |pmid=11443143 |doi-access=free }}</ref>
===Adrenal destruction=== Autoimmune adrenalitis (Addison's disease) is the most common cause of primary adrenal insufficiency in the industrialised world, causing 80–90% of cases since 1950.<ref name=":0" /> Autoimmune destruction of the adrenal cortex is caused by an immune reaction against the enzyme 21-hydroxylase (a phenomenon first described in 1992).<ref>{{cite journal |vauthors=Winqvist O, Karlsson FA, Kämpe O |date=June 1992 |title=21-Hydroxylase, a major autoantigen in idiopathic Addison's disease |journal=The Lancet |volume=339 |issue=8809 |pages=1559–62 |doi=10.1016/0140-6736(92)91829-W |pmid=1351548 |s2cid=19666235}}</ref> This may be isolated or in the context of autoimmune polyendocrine syndrome (APS type 1 or 2), in which other hormone-producing organs, such as the thyroid and pancreas, may also be affected.<ref>{{cite journal |last1=Husebye |first1=E. S. |last2=Perheentupa |first2=J. |last3=Rautemaa |first3=R. |last4=Kämpe |first4=O. |date=May 2009 |title=Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I |journal=Journal of Internal Medicine |volume=265 |issue=5 |pages= 514–529 |doi=10.1111/j.1365-2796.2009.02090.x |pmid=19382991 |doi-access=free}}</ref>
Autoimmune adrenalitis may be part of type 2 autoimmune polyglandular syndrome, which can include type 1 diabetes, hyperthyroidism, and autoimmune thyroid disease (also known as autoimmune thyroiditis, Hashimoto's thyroiditis, and Hashimoto's disease).<ref name="topic47.htm">{{cite journal |author=Thomas A Wilson, MD |year=2007 |title=Adrenal Insufficiency |url=http://www.emedicine.com/PED/topic47.htm |journal=Adrenal Gland Disorders}}</ref> Hypogonadism may also present with this syndrome. Other diseases that are more common in people with autoimmune adrenalitis include premature ovarian failure, celiac disease, and autoimmune gastritis with pernicious anemia.<ref name="BornsteinAllolio2016">{{cite journal |vauthors=Bornstein SR, Allolio B, Arlt W, Barthel A, Don-Wauchope A, Hammer GD et al. |year=2016 |title=Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline |journal=J Clin Endocrinol Metab |type=Practice Guideline. Review |volume=101 |issue=2 |pages=364–89 |doi=10.1210/jc.2015-1710 |pmc=4880116 |pmid=26760044}}</ref>
Adrenal destruction is a feature of adrenoleukodystrophy (ALD).<ref name="921176192.html">{{Cite web |date=11 March 1999 |orig-year=7 April 1998 |title=Adrenoleukodystrophy: What is Adrenoleukodystrophy? |url=http://healthlink.mcw.edu/article/921176192.html |archive-url=https://web.archive.org/web/20000109145216/http://healthlink.mcw.edu/article/921176192.html |archive-date=9 January 2000 |url-status=dead |work=MCW HealthLink |publisher=Medical College of Wisconsin |access-date=5 April 2024}}</ref> Destruction also occurs when the adrenal glands are involved in metastasis (seeding of cancer cells from elsewhere in the body, especially lung), hemorrhage (e.g. in Waterhouse–Friderichsen syndrome or antiphospholipid syndrome), particular infections which can spread to the adrenal cortex (tuberculosis, histoplasmosis, coccidioidomycosis), or the deposition of abnormal protein in amyloidosis.<ref name="medical-library.net">{{cite web |last1=Kennedy |first1=Ron |title=Addison's Disease |url=http://www.medical-library.net/content/view/570/41/ |url-status=dead |archive-url=https://web.archive.org/web/20130412101933/http://www.medical-library.net/content/view/570/41/ |archive-date=2013-04-12 |access-date=2015-07-29 |publisher=The Doctors' Medical Library}}</ref>
===Impaired steroidogenesis=== To form cortisol, the adrenal gland requires cholesterol, which is then converted biochemically into steroid hormones. Interruptions in the delivery of cholesterol include Smith–Lemli–Opitz syndrome and abetalipoproteinemia.{{needs verification|date=August 2020}}
Of the synthesis problems, congenital adrenal hyperplasia is the most common (in various forms: 21-hydroxylase, 17α-hydroxylase, 11β-hydroxylase and 3β-hydroxysteroid dehydrogenase), lipoid CAH due to deficiency of StAR and mitochondrial DNA mutations.<ref name="Ten" /> Some medications interfere with steroid synthesis enzymes (e.g. ketoconazole), while others accelerate the normal breakdown of hormones by the liver (e.g. rifampicin, phenytoin).<ref name="Ten" />
Adrenal insufficiency can also result when a patient has a brain mass in the pituitary gland (e.g. pituitary adenoma, craniopharyngioma) which can take up space and interfere with the secretion of pituitary hormones such as ACTH, therefore leading to decreased adrenal stimulation (secondary adrenal insufficiency).<ref name=":0" /> The same can occur with masses in the hypothalamus (tertiary adrenal insufficiency).<ref name=":0" />
==== Corticosteroid withdrawal ==== Use of high-dose steroids for more than a week begins to produce suppression of the person's adrenal glands because the exogenous glucocorticoids suppress release of hypothalamic corticotropin-releasing hormone (CRH) and pituitary adrenocorticotropic hormone (ACTH). With prolonged suppression, the adrenal glands atrophy (physically shrink), and can take months to recover full function after discontinuation of the exogenous glucocorticoid. During this recovery time, the person is vulnerable to adrenal insufficiency during times of stress, such as illness, due to both adrenal atrophy and suppression of CRH and ACTH release.<ref name="medicinenet">{{cite web |last1=Kaminstein |first1=David S. |title=Steroid Drug Withdrawal |url=http://www.medicinenet.com/steroid_withdrawal/article.htm |access-date=10 April 2013 |publisher=MedicineNet |editor1=William C. Shiel Jr.}}</ref><ref>{{cite journal |last1=Dernis |first1=Emmanuelle |last2=Ruyssen-Witrand |first2=Adeline |last3=Mouterde |first3=Gaël |last4=Maillefert |first4=Jean-Francis |last5=Tebib |first5=Jacques |last6=Cantagrel |first6=Alain |last7=Claudepierre |first7=Pascal |last8=Fautrel |first8=Bruno |last9=Gaudin |first9=Philippe |last10=Pham |first10=Thao |last11=Schaeverbeke |first11=Thierry |last12=Wendling |first12=Daniel |last13=Saraux |first13=Alain |last14=Loët |first14=Xavier Le |date=October 2010 |title=Use of glucocorticoids in rheumatoid arthritis – {{sic|nolink=y|Pratical}} modalities of glucocorticoid therapy: Recommendations for clinical practice based on data from the literature and expert opinion |journal=Joint Bone Spine |volume=77 |issue=5 |pages=451–457 |doi=10.1016/j.jbspin.2009.12.010 |pmid=20471886}}</ref> Use of steroids joint injections may also result in adrenal suppression after discontinuation.<ref>{{cite book |last1=Stitik |first1=Todd P. |url=https://books.google.com/books?id=sI7MZLDHcjQC&pg=PA47 |title=Injection Procedures: Osteoarthritis and Related Conditions |date=2010 |publisher=Springer Science & Business Media |isbn=9780387765952 |page=47 |language=en}}</ref>
===Adrenal dysgenesis=== All causes in this category are genetic and generally very rare. These include mutations to the ''SF1'' transcription factor, congenital adrenal hypoplasia due to ''DAX-1'' gene mutations and mutations to the ACTH receptor gene (or related genes, such as in the Triple A or Allgrove syndrome). ''DAX-1'' mutations may cluster in a syndrome with glycerol kinase deficiency with a number of other symptoms when ''DAX-1'' is deleted together with a number of other genes.<ref name="Ten" />
==Diagnosis== The first step of diagnosing adrenal insufficiency is confirming inappropriately low cortisol secretion.<ref name=":0" /> This is followed by determining the origin of dysfunction (adrenal glands, pituitary gland, or hypothalamus) and therefore the type of adrenal insufficiency (primary, secondary, or tertiary).<ref name=":0" /> After narrowing down the source, further testing can elucidate the cause of insufficiency.<ref name=":0" />
If a patient is suspected to be experiencing an acute adrenal crisis, immediate treatment with IV corticosteroids is imperative and should not be delayed for any testing, as the patient's health can deteriorate rapidly and result in death without replacing the corticosteroids.<ref name=":0" /><ref name=":1" /> Dexamethasone should be used as the corticosteroid of choice in these cases as it is the only corticosteroid that will not affect diagnostic test results.<ref name=":0" /><ref name=":4">{{EMedicine|article|116467|Addison Disease|workup}}</ref>
To confirm inappropriately low cortisol secretion, testing may include baseline morning cortisol level in the blood or morning cortisol level in the saliva.<ref name=":0" /> Cortisol levels typically peak in the morning; thus, low values indicate true adrenal insufficiency.<ref name=":0" /> Urinary free cortisol can also be measured, but is not necessary for diagnosis.<ref name=":0" />
To determine the origin of dysfunction, the ACTH stimulation test is the best initial test as it can differentiate between primary and secondary adrenal insufficiency.<ref name=":0" /> If cortisol levels remain low following ACTH stimulation, then the diagnosis is primary adrenal insufficiency.<ref name=":0" /> If cortisol levels increase following ACTH stimulation, then the diagnosis is either secondary or tertiary adrenal insufficiency.<ref name=":0" /> The corticotropin-releasing hormone test can then differentiate between secondary and tertiary adrenal insufficiency.<ref name=":0" /> Additional testing can include basal plasma ACTH, renin, and aldosterone concentrations, as well as a blood chemistry panel to check for electrolyte imbalances.<ref name=":0" />
Depending on the type of adrenal insufficiency, there are several possible causes and therefore many different avenues of testing (see Causes above). For primary adrenal insufficiency, the most common cause is autoimmune adrenalitis (Addison's disease); therefore, 21-hydroxylase autoantibodies should be checked.<ref name=":0" /> Structural abnormalities of the adrenal glands can be detected on CT imaging.<ref name=":0" /> For secondary and tertiary adrenal insufficiency, an MRI of the brain can be obtained to detect structural abnormalities such as masses, metastasis, hemorrhage, infarction, or infection.<ref name=":0" />
=== Effects === {| border="4" cellspacing="1" cellpadding="4" style="text-align:center; margin:10px;" |- | style="background:#ddcef2" | '''Source of pathology'''|| style="background:#cef2e0" |'''CRH'''|| style="background:#cef2e0" |'''ACTH'''|| style="background:#cef2e0" |'''DHEA'''|| style="background:#cef2e0" |'''DHEA-S'''|| style="background:#cef2e0" |'''cortisol'''||style="background:#cef2e0;" |'''aldosterone'''|| style="background:#cef2e0" |'''renin'''|| style="background:#cef2e0" |'''Na'''|| style="background:#cef2e0" |'''K'''|| style="background:#f2e0ce" |'''Causes'''<sup>5</sup> |- | style="background:#cedff2" | '''hypothalamus'''<br />(tertiary)<sup>1</sup>|| style="background:#F8F8F8" |low|| style="background:#F8F8F8"|low|| style="background:#F8F8F8" |low|| style="background:#F8F8F8" |low|| style="background:#F8F8F8" |low<sup>3</sup>||style="background:#F8F8F8" |normal|| style="background:#F8F8F8" |low|| style="background:#F8F8F8" |low|| style="background:#F8F8F8" |low||style="background:#F8F8F8" |tumor of the hypothalamus (adenoma), antibodies, environment (i.e. toxins), head injury |- | style="background:#cedff2" | '''pituitary'''<br />(secondary)|| style="background:#F8F8F8" |high<sup>2</sup>|| style="background:#F8F8F8"|low|| style="background:#F8F8F8" |low|| style="background:#F8F8F8" |low|| style="background:#F8F8F8" |low<sup>3</sup>||style="background:#F8F8F8" |normal|| style="background:#F8F8F8" |low|| style="background:#F8F8F8" |low|| style="background:#F8F8F8" |normal||style="background:#F8F8F8" |tumor of the pituitary (adenoma), antibodies, environment, head injury,<br />'''surgical removal'''<sup>6</sup>, Sheehan's syndrome |- | style="background:#cedff2" | '''adrenal glands'''<br />(primary)<sup>7</sup>|| style="background:#F8F8F8" |high|| style="background:#F8F8F8"|high|| style="background:#F8F8F8" |high|| style="background:#F8F8F8" |high|| style="background:#F8F8F8" |low<sup>4</sup>||style="background:#F8F8F8" |low|| style="background:#F8F8F8" |high|| style="background:#F8F8F8" |low|| style="background:#F8F8F8" |high||style="background:#F8F8F8" |tumor of the adrenal (adenoma), stress, antibodies, environment, Addison's disease, trauma, surgical removal (resection), miliary tuberculosis of the adrenal |}
{| border="2" cellspacing="1" cellpadding="2" style="margin:10px;" |- | '''1'''|| Automatically includes diagnosis of secondary (hypopituitarism) |- | '''2'''|| Only if CRH production in the hypothalamus is intact |- | '''3'''|| Value doubles or more in stimulation |- | '''4'''|| Value less than doubles in stimulation |- | '''5'''|| Most common, does not include all possible causes |- | '''6'''|| Usually because of a very large tumor (macroadenoma) |- | '''7'''|| Includes Addison's disease |}
==Treatment== In general, the treatment of adrenal insufficiency requires replacement of deficient hormones, as well as treatment of any underlying cause.<ref name=":0" /><ref name=":1" /> All types of adrenal insufficiency will require glucocorticoid repletion.<ref name=":0" /><ref name=":1" /> Many cases (typically, primary adrenal insufficiency) will also require mineralocorticoid repletion.<ref name=":0" /><ref name=":1" /> In rarer cases, repletion of androgens may also be indicated, typically in female patients with mood disturbances and changes in well-being.<ref name=":0" /><ref name=":1" /> * Adrenal crisis (acute) treatment ** Intravenous fluids<ref name="ch164b.html" /><ref name=":0" /><ref name=":1" /> ** Intravenous glucocorticoids<ref name="ch164b.html" /><ref name=":0" /><ref name=":1" /> *** typically hydrocortisone (Cortef) but dexamethasone (Decadron) may be used if diagnostic studies are necessary, as dexamethasone does not affect testing results<ref name=":0" /><ref name=":4" /> ** Supportive measures and correction of any additional issues such as electrolyte abnormalities<ref name=":0" /><ref name=":1" /> * Chronic adrenal insufficiency treatment ** Glucocorticoid deficiency (low cortisol) *** Oral glucocorticoids<ref name=":0" /><ref name=":1" /> **** Hydrocortisone (brand name: Cortef), or **** Prednisone (brand name: Deltasone), or **** Dexamethasone (brand name: Decadron) ** Mineralocorticoid deficiency (low aldosterone) treatment *** Oral mineralocorticoids<ref name=":0" /><ref name=":1" /> **** Fludrocortisone (brand name: Florinef) ** Sex hormone deficiency (low androgen) *** Oral androgens<ref name=":0" /><ref name=":1" /> **** Dehydroepiandrosterone (DHEA)
== Prognosis == Primary adrenal insufficiency predisposes to a higher risk of death, mostly due to infection, cardiovascular disease, and adrenal crisis.<ref name=":0" /> Delayed diagnosis can impair quality of life, and lack of treatment brings high mortality.<ref name=":0" /> However, with proper diagnosis, monitoring, and treatment, people with adrenal insufficiency can live normally.<ref name=":1" />
== Epidemiology == The most common cause of primary adrenal insufficiency (Addison's disease) overall is autoimmune adrenalitis.<ref name=":0" /> The prevalence of Addison's disease ranges from 5 to 221 per million in different countries.<ref name="pmid31321757">{{cite journal | vauthors = Betterle C, Presotto F, Furmaniak J | title = Epidemiology, pathogenesis, and diagnosis of Addison's disease in adults | journal = J Endocrinol Invest | volume = 42 | issue = 12 | pages = 1407–1433 | date = December 2019 | pmid = 31321757 | doi = 10.1007/s40618-019-01079-6 | s2cid = 197663861 | url = }}</ref>
In children, congenital adrenal hyperplasia (CAH) is the most common cause of adrenal insufficiency, with an incidence of 1 in 14,200 live births.<ref name=":1" />
== See also == * Addison's disease – primary adrenocortical insufficiency * Adrenal fatigue (hypoadrenia) – a term used in alternative medicine to describe a believed exhaustion of the adrenal glands * Cushing's syndrome – overproduction of cortisol * Insulin tolerance test – another test used to identify sub-types of adrenal insufficiency * Adrenal gland disorder
==References== {{reflist|30em}}
==Further reading== * {{cite journal |last1=Bornstein |first1=Stefan R. |last2=Allolio |first2=Bruno |last3=Arlt |first3=Wiebke |last4=Barthel |first4=Andreas |last5=Don-Wauchope |first5=Andrew |last6=Hammer |first6=Gary D. |last7=Husebye |first7=Eystein S. |last8=Merke |first8=Deborah P. |last9=Murad |first9=M. Hassan |last10=Stratakis |first10=Constantine A. |last11=Torpy |first11=David J. |title=Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline |journal=The Journal of Clinical Endocrinology & Metabolism |date=February 2016 |volume=101 |issue=2 |pages=364–389 |doi=10.1210/jc.2015-1710 |pmid=26760044 |pmc=4880116 }}
<!-- BEFORE inserting new links here you should first post it to the talk page, otherwise your edit may be reverted--> {{Medical resources | DiseasesDB = | ICD11 = {{ICD11|5A74}} | ICD10 = {{ICD10|E|27|1|e|20}}-{{ICD10|E|27|4|e|20}} | ICD9 = {{ICD9|255.4}} | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = emerg | eMedicineTopic = 16 | MeshID = D000309 }} {{Hypothalamic disease}} {{Shock types}}
{{DEFAULTSORT:Adrenal Insufficiency}} Category:Adrenal gland disorders