{{short description|Volume of arterial blood effectively perfusing tissue}}
In hematology, '''effective circulating volume''' ('''ECV''') is the volume of arterial blood effectively perfusing tissue.<ref name="Rennke">{{cite book |last1=Rennke |first1=Helmut G. |last2=Denker |first2=Bradley M. |title=Renal Pathophysiology: The Essentials |date=2007 |publisher=Lippincott Williams & Wilkins |isbn=9780781796262 |page=[https://archive.org/details/renalpathophysio0000renn/page/46 46] |url=https://archive.org/details/renalpathophysio0000renn |url-access=registration |quote=Effective circulating volume. |access-date=1 November 2018 |language=en}}</ref><ref>{{cite book |last1=Marik |first1=Paul Ellis |title=Handbook of Evidence-Based Critical Care |date=2001 |publisher=Springer Science & Business Media |isbn=9780387951539 |page=110 |url=https://books.google.com/books?id=AVH-OrOifV8C&q=%22Effective+circulating+volume%22 |access-date=1 November 2018 |language=en}}</ref> ECV is a dynamic quantity and not a measurable, distinct compartment.<ref name="Rennke" /> This concept is useful for discussion of cardiovascular and renal physiology.
Though ECV normally varies with extracellular fluid (ECF), they become uncoupled in diseases, such as congestive heart failure (CHF) or hepatic cirrhosis. In such cases, decreased ECV may lead to volume depletion responses and edema.{{cn|date=March 2021}}
Decreased ECV can stimulate renin secretion or stimulate a sympathetic nervous system response or prostaglandin release (all of which help mediate renal blood flow and glomerular filtration rate among other things).{{cn|date=March 2021}}
==See also== * Blood plasma
==References== {{reflist}}
==Sources== * John Bullock, Michael B. Wang, Joseph Boyle. ''NMS Physiology''. 4th ed., Lippincott Williams & Wilkins, 2001. pp 337-339.
Category:Cardiovascular physiology