{{Short description|Enzyme found in humans}} {{infobox gene}}

'''Caspase 4''' is an enzyme that in human is encoded by the CASP4 gene.

Caspase 4 proteolytically cleaves other proteins at an aspartic acid residue (LEVD-), and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and the murine homolog caspase 11), with a role in the immune system.<ref>{{cite journal |vauthors=Martinon F, Tschopp J |title=Inflammatory caspases and inflammasomes: master switches of inflammation |journal=Cell Death Differ. |volume=14 |issue=1 |pages=10–22 |year=2007 |pmid=16977329 |doi=10.1038/sj.cdd.4402038|doi-access=free }}</ref>

The anti-inflammatory drug indoprofen is an inhibitor of the activity of the caspase-4 enzyme.<ref>{{cite journal |vauthors=Smith C, Soti S, Jones Torey A, Nakagawa A, Xue D, and Yin H |title=NSAIDs are Caspase Inhibitors |journal=Cell Chem Biol |volume=24 |issue=3 |pages=281–292 |year=2017 |pmid=28238723|doi=10.1016/j.chembiol.2017.02.003|pmc=5357154 |doi-access=free }}</ref>

==See also== * The Proteolysis Map * Caspase

==References== {{Reflist}}

==External links== * The MEROPS online database for peptidases and their inhibitors: [https://archive.today/20121223044533/http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=C14.007 C14.007]

{{Cysteine proteases}} {{Enzymes}} {{Portal bar|Biology|border=no}}

Category:EC 3.4.22 Category:Caspases

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