{{Short description|Absence of the lens of the eye}} {{distinguish|Aphagia|Aphasia}} {{Infobox medical condition (new) | name = Aphakia | synonyms = | image = Starbrille 2018 PD 04.JPG | caption = A person with aphakia wearing cataract glasses, with extremely thick lenses to correct the typical extreme farsightedness. Before in-eye lens replacement was available, such glasses were much more common. | pronounce = | field = ophthalmology | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }} '''Aphakia''' is the absence of the lens of the eye, due to surgical removal, such as in cataract surgery, a perforating wound or ulcer, or congenital anomaly. It causes a loss of ability to maintain focus (accommodation), high degree of farsightedness (hyperopia),<ref name="Khurana" /> and a deep anterior chamber. Complications include detachment of the vitreous or retina, and glaucoma. Babies are rarely born with aphakia. Occurrence most often results from surgery to remove a congenital cataract. Congenital cataracts usually develop as a result of infection of the fetus or genetic reasons. It is often difficult to identify the exact cause of these cataracts, especially if only one eye is affected.
People with aphakia have relatively small pupils and their pupils dilate to a lesser degree.<ref>{{cite journal |author=Mary V Gibbens |author2=R Goel |author3=S E Smith |year=1989 |title=Effect of cataract extraction on the pupil response to mydriatics |journal=British Journal of Ophthalmology |volume=73 |issue=7 |pages=563–565 |doi=10.1136/bjo.73.7.563 |pmc=1041802 |pmid=2757997}}</ref>
==Signs and symptoms== * Hypermetropia: Without the focusing power of the lens, the eye becomes very farsighted.{{cn|date=November 2025}} * Loss of accommodation: Since the lens and its zonules are responsible for adjusting the focus of vision to different lengths, patients with aphakia will have a total loss of accommodation.{{cn|date=November 2025}} * Defective vision: High degree hypermetropia and total loss of accommodation cause defective vision for both distance and near.{{cn|date=November 2025}} * Cyanopsia: Absence of lens cause cyanopsia or blue vision.<ref name="Khurana" /> Some individuals have said that they perceive ultraviolet light, invisible to those with a lens, as whitish blue or whitish-violet.<ref>{{cite journal |author=R M Anderson |year=1983 |title=Visual perceptions and observations of an aphakic surgeon |journal=Perceptual and Motor Skills |volume=57 |issue=3_suppl |pages=1211–1218 |doi=10.2466/pms.1983.57.3f.1211 |pmid=6664798 |s2cid=20005737}}</ref><ref>{{cite news |author=David Hambling |date=29 May 2002 |title=Let the light shine in |url=https://www.theguardian.com/science/2002/may/30/medicalscience.research |newspaper=The Guardian}}</ref> * Erythropsia: Sometimes, objects appear reddish.<ref name="Khurana" /> * Deep anterior chamber: Since the lens is absent, anterior chamber will be deep.{{cn|date=November 2025}} * Iridodonesis:<ref name="Khurana" /> Iridodonesis is the vibration or agitated motion of the iris with eye movement. * Purkinje test shows only two images; the reflection from anterior and posterior corneal surfaces.<ref name="Khurana" /> * Iridectomy mark may be seen in surgical aphakia.<ref name=":0">{{Cite book |title=Textbook of ophthalmology Vol 1 |date=2002 |publisher=Jaypee Bros. Medical Publishers |others=Agarwal, Sunita. |isbn=978-81-7179-884-1 |location=New Delhi, India |oclc=49561947}}</ref> * Astigmatism: With-the-rule astigmatism due to corneal wound healing may occur in surgical aphakia, mainly after intracapsular cataract extraction or extracapsular cataract extraction.<ref name=":0" />
=== Complications === Main complications of surgical aphakia include: * Spectacle intolerance: Due to image magnification (up to 30%), optical aberration, prismatic effect and roving ring scotoma, spectacles are not well tolerated by aphakic patients.<ref name=":1" /> Due to unequal refractive power between the eyes, wearing spectacles with single-eye aphakia may cause double vision.<ref name=":1" /> * Glaucoma: Secondary angle closure glaucoma may occur due to vitreous prolapse.<ref>{{Cite journal |last=Sowka |first=Joseph W. |date=November 2002 |title=Pupil block glaucoma from traumatic vitreous prolapse in a patient with posterior chamber lens implantation |journal=Optometry (St. Louis, Mo.) |volume=73 |issue=11 |pages=685–693 |issn=1529-1839 |pmid=12516797}}</ref> * Retinal detachment<ref>{{Cite book |title=Ophthalmology |publisher=Elsevier |others=Yanoff, Myron,, Duker, Jay S., 1958- |year=2019 |isbn=978-0-323-52821-4 |edition=5th |location=Edinburgh |oclc=1051774434}}</ref> * Aphakic bullous keratopathy<ref name=":1">{{Cite book |last1=Ramanjit |first1=Sihota |title=Parsons' diseases of the eye |last2=Radhika |first2=Tandon |publisher=Elsevier |year=2015 |isbn=978-81-312-3819-6 |edition=22nd |location=New Delhi, India |oclc=905915528}}</ref>
==Causes== Surgical removal of a lens, mainly in cataract surgery, is the most common cause of aphakia.<ref name="Khurana">{{cite book |last1=Khurana |first1=AK |title=Comprehensive ophthalmology |publisher=Jaypee, The Health Sciences Publisher |year=2015 |isbn=978-93-86056-59-7 |edition=6th |pages=37–38 |chapter=Errors of refraction and accommodation}}</ref> Spontaneous traumatic absorption or congenital absence of lens matter is rare.<ref name="IJO">{{cite journal |last1=Alpar |first1=John |date=1 April 1989 |title="Present state of management of aphakia. Future of spectacles and contact lenses". |url=http://www.ijo.in/article.asp?issn=0301-4738;year=1989;volume=37;issue=2;spage=54;epage=57;aulast=Alp |journal=Indian Journal of Ophthalmology |language=en |volume=37 |issue=2 |pages=54–57 |issn=0301-4738 |pmid=2583777}}</ref><ref>{{cite web |title=Congenital primary aphakia |url=https://rarediseases.info.nih.gov/diseases/9952/congenital-primary-aphakia#:~:text=Congenital%20primary%20aphakia%20(CPA)%20is,cornea%20blends%20with%20the%20sclera). |website=rarediseases.info.nih.gov}}</ref> Traumatic subluxation or dislocation of a lens may cause it.<ref name="Khurana" /> ==Diagnosis== {{Empty section|date=November 2025}}
==Treatment== Aphakia can be corrected by wearing glasses or contact lenses, by artificial lens implantation, or by refractive corneal surgeries.<ref name="Khurana" /> Eyes with artificial lenses are described as "pseudophakic".{{cn|date=November 2025}}
==Etymology== From Ancient Greek ''a-'', privative prefix + ''phakós'', lentil, anything shaped like a lentil, e.g. a lens, via New Latin.<ref>aphakia at Wiktionary https://en.wiktionary.org/wiki/aphakia</ref><ref>aphakia. (n.d.) Farlex Partner Medical Dictionary. (2012). Retrieved April 13, 2016 from http://medical-dictionary.thefreedictionary.com/aphakia</ref>
==References== {{reflist}}
== External links == {{Medical resources | DiseasesDB = 29608 | ICD10 = {{ICD10|H|27|0|h|25}}, {{ICD10|Q|12|3|q|10}} | ICD9 = {{ICD9|379.31}}, {{ICD9|743.35}} | ICDO = | OMIM = 610256 | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = D001035 }}
{{Eye pathology}} {{Congenital malformations and deformations of eye, ear, face and neck}}
Category:Congenital disorders of eyes Category:Disorders of lens