Sofronie may refer to:
Name
- Sofronie of Cioara, Romanian Orthodox saint
- Sofronie Drincec (born 1967), Romanian bishop
- Sofronie Vârnav, Moldavian and Romanian political figure, philanthropist, collector, and Orthodox clergyman
- Sofronie Vulpescu (1856 – 1923), Romanian cleric
Surname
- Nicoleta Daniela Șofronie (born 1988), Romanian artistic gymnast