{{Short description|Protein-coding gene in humans}} {{Infobox_gene}} '''Heterogeneous nuclear ribonucleoprotein G''' is a protein that in humans is encoded by the ''RBMX'' gene.<ref name="pmid10391206">{{cite journal | vauthors = Delbridge ML, Lingenfelter PA, Disteche CM, Graves JA | title = The candidate spermatogenesis gene RBMY has a homologue on the human X chromosome | journal = Nature Genetics | volume = 22 | issue = 3 | pages = 223–4 | date = Jul 1999 | pmid = 10391206 | doi = 10.1038/10279 | s2cid = 43301464 }}</ref><ref name="pmid10391207">{{cite journal | vauthors = Mazeyrat S, Saut N, Mattei MG, Mitchell MJ | title = RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene | journal = Nature Genetics | volume = 22 | issue = 3 | pages = 224–6 | date = Jul 1999 | pmid = 10391207 | doi = 10.1038/10282 | s2cid = 13071214 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RBMX RNA binding motif protein, X-linked| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=27316}}</ref>
== Function ==
This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified but their biological nature has not been determined.<ref name="entrez" />
== Interactions ==
RBMX has been shown to interact with SFRS10<ref name=pmid12165565>{{cite journal | vauthors = Hofmann Y, Wirth B | title = hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1 | journal = Human Molecular Genetics | volume = 11 | issue = 17 | pages = 2037–49 | date = Aug 2002 | pmid = 12165565 | doi = 10.1093/hmg/11.17.2037 | doi-access = free }}</ref> and CDC5L.<ref name=pmid11101529>{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6569–81 | date = Dec 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}</ref>
== References == {{reflist|30em}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Le Coniat M, Soulard M, Della Valle V, Larsen CJ, Berger R | title = Localization of the human gene encoding heterogeneous nuclear RNA ribonucleoprotein G (hnRNP-G) to chromosome 6p12 | journal = Human Genetics | volume = 88 | issue = 5 | pages = 593–5 | date = Mar 1992 | pmid = 1551662 | doi = 10.1007/bf00219352 | s2cid = 23980780 }} * {{cite journal | vauthors = Soulard M, Della Valle V, Siomi MC, Piñol-Roma S, Codogno P, Bauvy C, Bellini M, Lacroix JC, Monod G, Dreyfuss G | title = hnRNP G: sequence and characterization of a glycosylated RNA-binding protein | journal = Nucleic Acids Research | volume = 21 | issue = 18 | pages = 4210–7 | date = Sep 1993 | pmid = 7692398 | pmc = 310052 | doi = 10.1093/nar/21.18.4210 }} * {{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Research | volume = 6 | issue = 9 | pages = 807–28 | date = Sep 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 | doi-access = free }} * {{cite journal | vauthors = Venables JP, Vernet C, Chew SL, Elliott DJ, Cowmeadow RB, Wu J, Cooke HJ, Artzt K, Eperon IC | title = T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis | journal = Human Molecular Genetics | volume = 8 | issue = 6 | pages = 959–69 | date = Jun 1999 | pmid = 10332027 | doi = 10.1093/hmg/8.6.959 | doi-access = free | hdl = 2381/22292 | hdl-access = free }} * {{cite journal | vauthors = Venables JP, Elliott DJ, Makarova OV, Makarov EM, Cooke HJ, Eperon IC | title = RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing | journal = Human Molecular Genetics | volume = 9 | issue = 5 | pages = 685–94 | date = Mar 2000 | pmid = 10749975 | doi = 10.1093/hmg/9.5.685 | doi-access = free }} * {{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6569–81 | date = Dec 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }} * {{cite journal | vauthors = Lingenfelter PA, Delbridge ML, Thomas S, Hoekstra HE, Mitchell MJ, Graves JA, Disteche CM | title = Expression and conservation of processed copies of the RBMX gene | journal = Mammalian Genome | volume = 12 | issue = 7 | pages = 538–45 | date = Jul 2001 | pmid = 11420617 | doi = 10.1007/s00335001-0003-z | citeseerx = 10.1.1.721.2504 | s2cid = 7201204 }} * {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = RNA | volume = 8 | issue = 4 | pages = 426–39 | date = Apr 2002 | article-number = S1355838202021088 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }} * {{cite journal | vauthors = Hofmann Y, Wirth B | title = hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1 | journal = Human Molecular Genetics | volume = 11 | issue = 17 | pages = 2037–49 | date = Aug 2002 | pmid = 12165565 | doi = 10.1093/hmg/11.17.2037 | doi-access = free }} * {{cite journal | vauthors = Angenstein F, Evans AM, Settlage RE, Moran ST, Ling SC, Klintsova AY, Shabanowitz J, Hunt DF, Greenough WT | title = A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons | journal = The Journal of Neuroscience | volume = 22 | issue = 20 | pages = 8827–37 | date = Oct 2002 | pmid = 12388589 | doi = 10.1523/JNEUROSCI.22-20-08827.2002| pmc = 6757688 | doi-access = free }} * {{cite journal | vauthors = Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG | title = Regulation of alternative splicing by SRrp86 and its interacting proteins | journal = Molecular and Cellular Biology | volume = 23 | issue = 21 | pages = 7437–47 | date = Nov 2003 | pmid = 14559993 | pmc = 207616 | doi = 10.1128/MCB.23.21.7437-7447.2003 }} * {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry | journal = Analytical Chemistry | volume = 76 | issue = 10 | pages = 2763–72 | date = May 2004 | pmid = 15144186 | doi = 10.1021/ac035352d | bibcode = 2004AnaCh..76.2763B | url = https://figshare.com/articles/journal_contribution/3339307/files/5178523.pdf }} * {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | bibcode = 2004PNAS..10112130B | doi-access = free }} * {{cite journal | vauthors = Ong SE, Mittler G, Mann M | title = Identifying and quantifying in vivo methylation sites by heavy methyl SILAC | journal = Nature Methods | volume = 1 | issue = 2 | pages = 119–26 | date = Nov 2004 | pmid = 15782174 | doi = 10.1038/nmeth715 | s2cid = 6654604 }} {{refend}}