{{cs1 config|name-list-style=vanc}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Phospholipid scramblase 1''' ('''PL scramblase 1''') is an enzyme that in humans is encoded by the ''PLSCR1'' gene.<ref name="pmid9218461">{{cite journal | vauthors = Zhou Q, Zhao J, Stout JG, Luhm RA, Wiedmer T, Sims PJ | title = Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids | journal = J Biol Chem | volume = 272 | issue = 29 | pages = 18240–4 | date = August 1997 | pmid = 9218461 | doi = 10.1074/jbc.272.29.18240 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLSCR1 phospholipid scramblase 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5359}}</ref>
== Interactions ==
PLSCR1 has been shown to interact with: {{div col|colwidth=20em}} * CPSF6,<ref name = pmid16189514/> * Epidermal growth factor receptor,<ref name = pmid12009895/> * NEU4,<ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}</ref> * SHC1,<ref name = pmid12009895>{{cite journal | vauthors = Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ | title = Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor | journal = Biochemistry | volume = 41 | issue = 20 | pages = 6338–45 | date = May 2002 | pmid = 12009895 | doi = 10.1021/bi025610l}}</ref><ref name = pmid12871937>{{cite journal | vauthors = Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T | title = Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor | journal = J. Biol. Chem. | volume = 278 | issue = 39 | pages = 37413–8 | date = September 2003 | pmid = 12871937 | doi = 10.1074/jbc.M306182200 | doi-access = free }}</ref> * SLPI,<ref name = pmid10869562>{{cite journal | vauthors = Tseng CC, Tseng CP | title = Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement | journal = FEBS Lett. | volume = 475 | issue = 3 | pages = 232–6 | date = June 2000 | pmid = 10869562 | doi = 10.1016/s0014-5793(00)01700-2| s2cid = 35688498 | doi-access = }}</ref> and * TFG.<ref name = pmid16189514/> {{Div col end}}
== See also == *Scramblase
== References == {{reflist}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Bassé F, Stout JG, Sims PJ, Wiedmer T | title = Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid. | journal = J. Biol. Chem. | volume = 271 | issue = 29 | pages = 17205–10 | year = 1996 | pmid = 8663431 | doi = 10.1074/jbc.271.29.17205 | doi-access = free }} * {{cite journal | vauthors = Zhou Q, Sims PJ, Wiedmer T | title = Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids. | journal = Biochemistry | volume = 37 | issue = 8 | pages = 2356–60 | year = 1998 | pmid = 9485382 | doi = 10.1021/bi972625o }} * {{cite journal | vauthors = Zhao J, Zhou Q, Wiedmer T, Sims PJ | title = Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids. | journal = Biochemistry | volume = 37 | issue = 18 | pages = 6361–6 | year = 1998 | pmid = 9572851 | doi = 10.1021/bi980218m }} * {{cite journal | vauthors = Kasukabe T, Kobayashi H, Kaneko Y, Okabe-Kado J, Honma Y | title = Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene | journal = Biochem. Biophys. Res. Commun. | volume = 249 | issue = 2 | pages = 449–55 | year = 1998 | pmid = 9712717 | doi = 10.1006/bbrc.1998.9190 }} * {{cite journal | vauthors = Zhou Q, Zhao J, Al-Zoghaibi F, Zhou A, Wiedmer T, Silverman RH, Sims PJ | title = Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha | journal = Blood | volume = 95 | issue = 8 | pages = 2593–9 | year = 2000 | pmid = 10753839 | doi = 10.1182/blood.V95.8.2593| url = http://www.bloodjournal.org/content/bloodjournal/95/8/2593.full.pdf?sso-checked=true }} * {{cite journal | vauthors = Frasch SC, Henson PM, Kailey JM, Richter DA, Janes MS, Fadok VA, Bratton DL | title = Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta | journal = J. Biol. Chem. | volume = 275 | issue = 30 | pages = 23065–73 | year = 2000 | pmid = 10770950 | doi = 10.1074/jbc.M003116200 | doi-access = free }} * {{cite journal | vauthors = Tseng CC, Tseng CP | title = Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement | journal = FEBS Lett. | volume = 475 | issue = 3 | pages = 232–6 | year = 2000 | pmid = 10869562 | doi = 10.1016/S0014-5793(00)01700-2 | s2cid = 35688498 | doi-access = }} * {{cite journal | vauthors = Wiedmer T, Zhou Q, Kwoh DY, Sims PJ | title = Identification of three new members of the phospholipid scramblase gene family | journal = Biochim. Biophys. Acta | volume = 1467 | issue = 1 | pages = 244–53 | year = 2000 | pmid = 10930526 | doi = 10.1016/S0005-2736(00)00236-4 | doi-access = free }} * {{cite journal | vauthors = Sun J, Zhao J, Schwartz MA, Wang JY, Wiedmer T, Sims PJ | title = c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1 | journal = J. Biol. Chem. | volume = 276 | issue = 31 | pages = 28984–90 | year = 2001 | pmid = 11390389 | doi = 10.1074/jbc.M102505200 | doi-access = free }} * {{cite journal | vauthors = Silverman RH, Halloum A, Zhou A, Dong B, Al-Zoghaibi F, Kushner D, Zhou Q, Zhao J, Wiedmer T, Sims PJ | title = Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1 | journal = Cancer Res. | volume = 62 | issue = 2 | pages = 397–402 | year = 2002 | pmid = 11809687 }} * {{cite journal | vauthors = Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ | title = Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor | journal = Biochemistry | volume = 41 | issue = 20 | pages = 6338–45 | year = 2002 | pmid = 12009895 | doi = 10.1021/bi025610l }} * {{cite journal | vauthors = Zhou Q, Zhao J, Wiedmer T, Sims PJ | title = Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1 | journal = Blood | volume = 99 | issue = 11 | pages = 4030–8 | year = 2002 | pmid = 12010804 | doi = 10.1182/blood-2001-12-0271 | doi-access = free }} * {{cite journal | vauthors = Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS | title = Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase | journal = J. Biol. Chem. | volume = 277 | issue = 31 | pages = 28051–7 | year = 2002 | pmid = 12023963 | doi = 10.1074/jbc.M202665200 | doi-access = free }} * {{cite journal | vauthors = Nakamaki T, Okabe-Kado J, Yamamoto-Yamaguchi Y, ((Hino Ki)), Tomoyasu S, Honma Y, Kasukabe T | title = Role of MmTRA1b/phospholipid scramblase1 gene expression in the induction of differentiation of human myeloid leukemia cells into granulocytes | journal = Exp. Hematol. | volume = 30 | issue = 5 | pages = 421–9 | year = 2002 | pmid = 12031648 | doi = 10.1016/S0301-472X(02)00779-8 | doi-access = free }} * {{cite journal | vauthors = Wiedmer T, Zhao J, Nanjundan M, Sims PJ | title = Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane | journal = Biochemistry | volume = 42 | issue = 5 | pages = 1227–33 | year = 2003 | pmid = 12564925 | doi = 10.1021/bi026679w }} * {{cite journal | vauthors = Kametaka S, Shibata M, Moroe K, Kanamori S, Ohsawa Y, Waguri S, Sims PJ, Emoto K, Umeda M, Uchiyama Y | title = Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE)) | journal = J. Biol. Chem. | volume = 278 | issue = 17 | pages = 15239–45 | year = 2003 | pmid = 12586838 | doi = 10.1074/jbc.M208611200 | doi-access = free}} * {{cite journal | vauthors = Rami A, Sims J, Botez G, Winckler J | title = Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia | journal = Neurochem. Int. | volume = 43 | issue = 1 | pages = 79–87 | year = 2003 | pmid = 12605885 | doi = 10.1016/S0197-0186(02)00194-8 | s2cid = 44845123 }} * {{cite journal | vauthors = Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T | title = Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor | journal = J. Biol. Chem. | volume = 278 | issue = 39 | pages = 37413–8 | year = 2003 | pmid = 12871937 | doi = 10.1074/jbc.M306182200 | doi-access = free }} {{refend}}
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