Sialidase-4

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Sialidase-4''' is an enzyme that in humans is encoded by the ''NEU4'' gene.<ref name="entrez">{{cite web | title = Entrez Gene: NEU4 sialidase 4| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=129807}}</ref>

== Function ==

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids.<ref name="entrez"/>

== Interactions == Sialidase-4 has been shown to interact with phospholipid scramblase 1.<ref name=pmid16189514>{{cite journal|author-link30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}</ref>

== References == {{reflist}} {{Clear}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Comelli EM, Amado M, Lustig SR, Paulson JC | title = Identification and expression of Neu4, a novel murine sialidase. | journal = Gene | volume = 321 | pages = 155–61 | year = 2004 | pmid = 14637003 | doi = 10.1016/j.gene.2003.08.005 }} * {{cite journal | vauthors = Monti E, Bassi MT, Bresciani R, Civini S, Croci GL, Papini N, Riboni M, Zanchetti G, Ballabio A, Preti A, Tettamanti G, Venerando B, Borsani G | title = Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. | journal = Genomics | volume = 83 | issue = 3 | pages = 445–53 | year = 2004 | pmid = 14962670 | doi = 10.1016/j.ygeno.2003.08.019 }} * {{cite journal | vauthors = Seyrantepe V, Landry K, Trudel S, Hassan JA, Morales CR, Pshezhetsky AV | title = Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells. | journal = J. Biol. Chem. | volume = 279 | issue = 35 | pages = 37021–9 | year = 2004 | pmid = 15213228 | doi = 10.1074/jbc.M404531200 | doi-access = free }} * {{cite journal | vauthors = Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J | title = Large-scale cDNA transfection screening for genes related to cancer development and progression. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 44 | pages = 15724–9 | year = 2004 | pmid = 15498874 | pmc = 524842 | doi = 10.1073/pnas.0404089101 | bibcode = 2004PNAS..10115724W | doi-access = free }} * {{cite journal | vauthors = Stamatos NM, Liang F, Nan X, Landry K, Cross AS, Wang LX, Pshezhetsky AV | title = Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages. | journal = FEBS J. | volume = 272 | issue = 10 | pages = 2545–56 | year = 2005 | pmid = 15885103 | doi = 10.1111/j.1742-4658.2005.04679.x | s2cid = 27379898 | doi-access = free }} {{refend}}

Category:Human proteins