{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Peflin''' is a protein that in humans is encoded by the ''PEF1'' gene.<ref name="pmid10486255">{{cite journal |vauthors=Kitaura Y, Watanabe M, Satoh H, Kawai T, Hitomi K, Maki M | title = Peflin, a novel member of the five-EF-hand-protein family, is similar to the apoptosis-linked gene 2 (ALG-2) protein but possesses nonapeptide repeats in the N-terminal hydrophobic region | journal = Biochem Biophys Res Commun | volume = 263 | issue = 1 | pages = 68–75 |date=Oct 1999 | pmid = 10486255 | doi = 10.1006/bbrc.1999.1189 }}</ref><ref name="pmid11883899">{{cite journal |vauthors=Kitaura Y, Satoh H, Takahashi H, Shibata H, Maki M | title = Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions | journal = Arch Biochem Biophys | volume = 399 | issue = 1 | pages = 12–8 |date=Mar 2002 | pmid = 11883899 | doi = 10.1006/abbi.2001.2736 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PEF1 penta-EF-hand domain containing 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=553115}}</ref>
PEF1 is a Ca(2+)-binding protein that belongs to the penta-EF hand (PEF) protein family, which includes the calpain small subunit (CAPNS1; MIM 114170), sorcin (SRI; MIM 182520), grancalcin (GCA; MIM 607030), and ALG2 (PDCD6; MIM 601057) (Kitaura et al., 2001).[supplied by OMIM]<ref name="entrez" />
==Interactions== PEF1 has been shown to interact with PDCD6.<ref name=pmid11278427>{{cite journal |last=Kitaura |first=Y |author2=Matsumoto S |author3=Satoh H |author4=Hitomi K |author5=Maki M |date=Apr 2001 |title=Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner |journal=J. Biol. Chem. |volume=276 |issue=17 |pages=14053–8 | issn = 0021-9258| pmid = 11278427 |doi = 10.1074/jbc.M008649200 |doi-access=free }}</ref>
==References== {{reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Kitaura Y, Matsumoto S, Satoh H, etal |title=Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner. |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 14053–8 |year= 2001 |pmid= 11278427 |doi= 10.1074/jbc.M008649200 |doi-access= free }} *{{cite journal |vauthors=Satoh H, Nakano Y, Shibata H, Maki M |title=The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner. |journal=Biochim. Biophys. Acta |volume=1600 |issue= 1–2 |pages= 61–7 |year= 2002 |pmid= 12445460 |doi= 10.1016/S1570-9639(02)00445-4}} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Hansen C, Tarabykina S, la Cour JM, etal |title=The PEF family proteins sorcin and grancalcin interact in vivo and in vitro. |journal=FEBS Lett. |volume=545 |issue= 2–3 |pages= 151–4 |year= 2003 |pmid= 12804766 |doi=10.1016/S0014-5793(03)00518-0 |doi-access= |s2cid=42572647 }} *{{cite journal |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }} *{{cite journal |vauthors=Jordanova A, Irobi J, Thomas FP, etal |title=Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. |journal=Nat. Genet. |volume=38 |issue= 2 |pages= 197–202 |year= 2006 |pmid= 16429158 |doi= 10.1038/ng1727 |s2cid=16668375 |url=https://lirias.kuleuven.be/handle/123456789/8070 |url-access=subscription }} {{refend}}
{{gene-1-stub}}
Category:Penta-EF-hand proteins