PDCD6

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Programmed cell death protein 6''' is a protein that in humans is encoded by the ''PDCD6'' gene.<ref name="pmid8560270">{{cite journal |vauthors=Vito P, Lacana E, D'Adamio L | title = Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3 | journal = Science | volume = 271 | issue = 5248 | pages = 521–5 | date=February 1996| pmid = 8560270 | doi =10.1126/science.271.5248.521 | bibcode =1996Sci...271..521V| s2cid = 22286752 | url = https://zenodo.org/record/1231054 }}</ref>

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant.<ref name="entrez">{{cite web | title = Entrez Gene: PDCD6 programmed cell death 6| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10016}}</ref>

==Interactions== PDCD6 has been shown to interact with ASK1,<ref name=pmid12372597>{{cite journal |last=Hwang |first=In-Sik |author2=Jung Yong-Sam |author3=Kim Eunhee |date=October 2002|title=Interaction of ALG-2 with ASK1 influences ASK1 localization and subsequent JNK activation |journal=FEBS Lett. |volume=529 |issue=2–3 |pages=183–7 |location = Netherlands| issn = 0014-5793| pmid = 12372597 |doi=10.1016/S0014-5793(02)03329-X |s2cid=9264865 |doi-access= |bibcode=2002FEBSL.529..183H }}</ref> PDCD6IP,<ref name=pmid9880530>{{cite journal |last=Vito |first=P |author2=Pellegrini L |author3=Guiet C |author4=D'Adamio L |date=January 1999|title=Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction |journal=J. Biol. Chem. |volume=274 |issue=3 |pages=1533–40 |location = UNITED STATES| issn = 0021-9258| pmid = 9880530 |doi=10.1074/jbc.274.3.1533 |doi-access=free }}</ref><ref name=pmid11883939>{{cite journal |last=Satoh |first=Hirokazu |author2=Shibata Hideki |author3=Nakano Yoshimi |author4=Kitaura Yasuyuki |author5=Maki Masatoshi |date=March 2002|title=ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue=5 |pages=1166–72 |location = United States| issn = 0006-291X| pmid = 11883939 |doi = 10.1006/bbrc.2002.6600 }}</ref> Fas receptor,<ref name=pmid11606059>{{cite journal |last=Jung |first=Y S |author2=Kim K S |author3=Kim K D |author4=Lim J S |author5=Kim J W |author6=Kim E |date=October 2001|title=Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue=2 |pages=420–6 |location = United States| issn = 0006-291X| pmid = 11606059 |doi = 10.1006/bbrc.2001.5769 }}</ref> ANXA11<ref name=pmid11883939/> and PEF1.<ref name=pmid11278427>{{cite journal |last=Kitaura |first=Y |author2=Matsumoto S |author3=Satoh H |author4=Hitomi K |author5=Maki M |date=April 2001|title=Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner |journal=J. Biol. Chem. |volume=276 |issue=17 |pages=14053–8 |location = United States| issn = 0021-9258| pmid = 11278427 |doi = 10.1074/jbc.M008649200 |doi-access=free }}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Krebs J, Klemenz R |title=The ALG-2/AIP-complex, a modulator at the interface between cell proliferation and cell death? A hypothesis |journal=Biochim. Biophys. Acta |volume=1498 |issue= 2–3 |pages= 153–61 |year= 2001 |pmid= 11108958 |doi= 10.1016/S0167-4889(00)00091-4|doi-access= }} *{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} *{{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }} *{{cite journal |vauthors=Vito P, Pellegrini L, Guiet C, D'Adamio L |title=Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction |journal=J. Biol. Chem. |volume=274 |issue= 3 |pages= 1533–40 |year= 1999 |pmid= 9880530 |doi=10.1074/jbc.274.3.1533 |doi-access=free }} *{{cite journal |vauthors=Tarabykina S, Møller AL, Durussel I, etal |title=Two forms of the apoptosis-linked protein ALG-2 with different Ca(2+) affinities and target recognition |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10514–8 |year= 2000 |pmid= 10744743 |doi=10.1074/jbc.275.14.10514 |doi-access=free }} *{{cite journal |vauthors=Chen B, Borinstein SC, Gillis J, etal |title=The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 19275–81 |year= 2000 |pmid= 10858458 |doi= 10.1074/jbc.M908994199 |doi-access= free }} *{{cite journal |vauthors=Kitaura Y, Matsumoto S, Satoh H, etal |title=Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 14053–8 |year= 2001 |pmid= 11278427 |doi= 10.1074/jbc.M008649200 |doi-access= free }} *{{cite journal |vauthors=Suzuki H, Fukunishi Y, Kagawa I, etal |title=Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 | pmc=311163 }} *{{cite journal |vauthors=Jung YS, Kim KS, Kim KD, etal |title=Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 2 |pages= 420–6 |year= 2001 |pmid= 11606059 |doi= 10.1006/bbrc.2001.5769 }} *{{cite journal |vauthors=Kitaura Y, Satoh H, Takahashi H, etal |title=Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions |journal=Arch. Biochem. Biophys. |volume=399 |issue= 1 |pages= 12–8 |year= 2002 |pmid= 11883899 |doi= 10.1006/abbi.2001.2736 }} *{{cite journal |vauthors=Satoh H, Shibata H, Nakano Y, etal |title=ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 5 |pages= 1166–72 |year= 2002 |pmid= 11883939 |doi= 10.1006/bbrc.2002.6600 }} *{{cite journal |vauthors=Chatellard-Causse C, Blot B, Cristina N, etal |title=Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 29108–15 |year= 2002 |pmid= 12034747 |doi= 10.1074/jbc.M204019200 |doi-access= free }} *{{cite journal |vauthors=Hwang IS, Jung YS, Kim E |title=Interaction of ALG-2 with ASK1 influences ASK1 localization and subsequent JNK activation |journal=FEBS Lett. |volume=529 |issue= 2–3 |pages= 183–7 |year= 2002 |pmid= 12372597 |doi=10.1016/S0014-5793(02)03329-X |s2cid=9264865 |doi-access= |bibcode=2002FEBSL.529..183H }} *{{cite journal |vauthors=Satoh H, Nakano Y, Shibata H, Maki M |title=The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner |journal=Biochim. Biophys. Acta |volume=1600 |issue= 1–2 |pages= 61–7 |year= 2002 |pmid= 12445460 |doi= 10.1016/S1570-9639(02)00445-4}} *{{cite journal |vauthors=Krebs J, Saremaslani P, Caduff R |title=ALG-2: a Ca2+ -binding modulator protein involved in cell proliferation and in cell death |journal=Biochim. Biophys. Acta |volume=1600 |issue= 1–2 |pages= 68–73 |year= 2002 |pmid= 12445461 |doi= 10.1016/S1570-9639(02)00446-6}} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Tomsig JL, Snyder SL, Creutz CE |title=Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10048–54 |year= 2003 |pmid= 12522145 |doi= 10.1074/jbc.M212632200 |doi-access= free }} *{{cite journal |vauthors=Hansen C, Tarabykina S, la Cour JM, etal |title=The PEF family proteins sorcin and grancalcin interact in vivo and in vitro |journal=FEBS Lett. |volume=545 |issue= 2–3 |pages= 151–4 |year= 2003 |pmid= 12804766 |doi=10.1016/S0014-5793(03)00518-0 |s2cid=42572647 |doi-access= |bibcode=2003FEBSL.545..151H }} {{refend}}

==External links== * {{UCSC genome browser|PDCD6}} * {{UCSC gene details|PDCD6}}

Category:Penta-EF-hand proteins