{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc|display-authors=6}} {{Infobox_gene}} '''Neighbor of BRCA1 gene 1 protein''' is a protein that in humans is encoded by the ''NBR1'' gene.<ref name="Campbell_1994">{{cite journal | vauthors = Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, Bast RC, Solomon E | title = A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1 | journal = Human Molecular Genetics | volume = 3 | issue = 4 | pages = 589–594 | date = April 1994 | pmid = 8069304 | doi = 10.1093/hmg/3.4.589 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NBR1 neighbor of BRCA1 gene 1 | url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4077 }}</ref>
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene ''BRCA1''. Three alternatively spliced variants encoding the same protein have been identified for this gene.<ref name="entrez" /> One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.<ref>{{cite journal | vauthors = Kirkin V, McEwan DG, Novak I, Dikic I | title = A role for ubiquitin in selective autophagy | journal = Molecular Cell | volume = 34 | issue = 3 | pages = 259–269 | date = May 2009 | pmid = 19450525 | doi = 10.1016/j.molcel.2009.04.026 | doi-access = free }}</ref>
== Interactions ==
NBR1 has been shown to interact with FEZ1.<ref name="Whitehouse_2002">{{cite journal | vauthors = Whitehouse C, Chambers J, Howe K, Cobourne M, Sharpe P, Solomon E | title = NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube | journal = European Journal of Biochemistry | volume = 269 | issue = 2 | pages = 538–545 | date = January 2002 | pmid = 11856312 | doi = 10.1046/j.0014-2956.2001.02681.x | doi-access = free }}</ref>
== References == {{reflist}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W | title = A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 | journal = Science | volume = 266 | issue = 5182 | pages = 66–71 | date = October 1994 | pmid = 7545954 | doi = 10.1126/science.7545954 | doi-access = free | bibcode = 1994Sci...266...66M }} * {{cite journal | vauthors = Harshman K, Bell R, Rosenthal J, Katcher H, Miki Y, Swenson J, Gholami Z, Frye C, Ding W, Dayananth P | title = Comparison of the positional cloning methods used to isolate the BRCA1 gene | journal = Human Molecular Genetics | volume = 4 | issue = 8 | pages = 1259–1266 | date = August 1995 | pmid = 7581362 | doi = 10.1093/hmg/4.8.1259 }} * {{cite journal | vauthors = Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S | title = Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 1 | issue = 5 | pages = 223–229 | year = 1995 | pmid = 7584044 | doi = 10.1093/dnares/1.5.223 | doi-access = free }} * {{cite journal | vauthors = Brown MA, Nicolai H, Xu CF, Griffiths BL, Jones KA, Solomon E, Hosking L, Trowsdale J, Black DM, McFarlane R | title = Regulation of BRCA1 | journal = Nature | volume = 372 | issue = 6508 | pages = 733 | year = 1995 | pmid = 7997258 | doi = 10.1038/372733a0 | s2cid = 40825012 | doi-access = free | bibcode = 1994Natur.372..733B }} * {{cite journal | vauthors = Brown MA, Xu CF, Nicolai H, Griffiths B, Chambers JA, Black D, Solomon E | title = The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21 | journal = Oncogene | volume = 12 | issue = 12 | pages = 2507–2513 | date = June 1996 | pmid = 8700509 }} * {{cite journal | vauthors = Dimitrov S, Brennerova M, Forejt J | title = Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes | journal = Gene | volume = 262 | issue = 1–2 | pages = 89–98 | date = January 2001 | pmid = 11179671 | doi = 10.1016/S0378-1119(00)00549-7 }} * {{cite journal | vauthors = Whitehouse C, Chambers J, Howe K, Cobourne M, Sharpe P, Solomon E | title = NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube | journal = European Journal of Biochemistry | volume = 269 | issue = 2 | pages = 538–545 | date = January 2002 | pmid = 11856312 | doi = 10.1046/j.0014-2956.2001.02681.x | doi-access = free }} * {{cite journal | vauthors = Wistow G, Bernstein SL, Ray S, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K | title = Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium | journal = Molecular Vision | volume = 8 | pages = 185–195 | date = June 2002 | pmid = 12107412 }} * {{cite journal | vauthors = Lamark T, Perander M, Outzen H, Kristiansen K, Øvervatn A, Michaelsen E, Bjørkøy G, Johansen T | title = Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins | journal = The Journal of Biological Chemistry | volume = 278 | issue = 36 | pages = 34568–34581 | date = September 2003 | pmid = 12813044 | doi = 10.1074/jbc.M303221200 | doi-access = free }} * {{cite journal | vauthors = Lange S, Xiang F, Yakovenko A, Vihola A, Hackman P, Rostkova E, Kristensen J, Brandmeier B, Franzen G, Hedberg B, Gunnarsson LG, Hughes SM, Marchand S, Sejersen T, Richard I, Edström L, Ehler E, Udd B, Gautel M | title = The kinase domain of titin controls muscle gene expression and protein turnover | journal = Science | volume = 308 | issue = 5728 | pages = 1599–1603 | date = June 2005 | pmid = 15802564 | doi = 10.1126/science.1110463 | s2cid = 2809403 | citeseerx = 10.1.1.383.9888 | bibcode = 2005Sci...308.1599L }} * {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–1178 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | s2cid = 4427026 | bibcode = 2005Natur.437.1173R }} {{refend}} {{PDB Gallery|geneid=4077}}
Category:Human proteins
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