{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Fasciculation and elongation protein zeta-1''' is a protein that in humans is encoded by the ''FEZ1'' gene.<ref name="pmid9096408">{{cite journal |vauthors=Bloom L, Horvitz HR | title = The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 7 | pages = 3414–9 |date=May 1997 | pmid = 9096408 | pmc = 20384 | doi =10.1073/pnas.94.7.3414 |bibcode = 1997PNAS...94.3414B | doi-access = free }}</ref><ref name="pmid15843383">{{cite journal |vauthors=Suzuki T, Okada Y, Semba S, Orba Y, Yamanouchi S, Endo S, Tanaka S, Fujita T, Kuroda S, Nagashima K, Sawa H | title = Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation | journal = J Biol Chem | volume = 280 | issue = 26 | pages = 24948–56 |date=Jun 2005 | pmid = 15843383 | doi = 10.1074/jbc.M411499200 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FEZ1 fasciculation and elongation protein zeta 1 (zygin I)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9638}}</ref>
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.<ref name="entrez"/>
This protein is present in neurons, and it is believed to block the process of infection of these cells by HIV.<ref>{{Cite journal | first1 = J.| last2 = Brown | first2 = C.| last3 = Naghavi | first3 = M. H.| journal = Proceedings of the National Academy of Sciences| volume = 106| last1 = Haedicke| title = The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection| issue = 33| pages = 14040–14045| date=Aug 2009 | issn = 0027-8424| pmid = 19667186| pmc = 2729016| doi = 10.1073/pnas.0900502106|bibcode = 2009PNAS..10614040H | doi-access = free }}</ref>
==Interactions== FEZ1 has been shown to interact with Protein kinase Mζ,<ref name=pmid9971736>{{cite journal |last=Kuroda |first=S |author2=Nakagawa N |author3=Tokunaga C |author4=Tatematsu K |author5=Tanizawa K |date=Feb 1999 |title=Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein |journal=J. Cell Biol. |volume=144 |issue=3 |pages=403–11 | issn = 0021-9525| pmid = 9971736 |doi=10.1083/jcb.144.3.403 |pmc=2132904 }}</ref> NBR1<ref name=pmid11856312>{{cite journal |last=Whitehouse |first=Caroline |author2=Chambers Julie |author3=Howe Kathy |author4=Cobourne Martyn |author5=Sharpe Paul |author6=Solomon Ellen |date=Jan 2002 |title=NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube |journal=Eur. J. Biochem. |volume=269 |issue=2 |pages=538–45 | issn = 0014-2956| pmid = 11856312 |doi=10.1046/j.0014-2956.2001.02681.x |doi-access=free }}</ref> and DISC1.<ref name=pmid12874605>{{cite journal |last=Miyoshi |first=K |author2=Honda A |author3=Baba K |author4=Taniguchi M |author5=Oono K |author6=Fujita T |author7=Kuroda S |author8=Katayama T |author9=Tohyama M |date=Jul 2003 |title=Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth |journal=Mol. Psychiatry |volume=8 |issue=7 |pages=685–94 | issn = 1359-4184| pmid = 12874605 |doi = 10.1038/sj.mp.4001352 |doi-access=free }}</ref>
==References== {{reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Kuroda S, Nakagawa N, Tokunaga C |title=Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. |journal=J. Cell Biol. |volume=144 |issue= 3 |pages= 403–11 |year= 1999 |pmid= 9971736 |doi=10.1083/jcb.144.3.403 | pmc=2132904 |display-authors=etal}} *{{cite journal |vauthors=Whitehouse C, Chambers J, Howe K |title=NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube. |journal=Eur. J. Biochem. |volume=269 |issue= 2 |pages= 538–45 |year= 2002 |pmid= 11856312 |doi=10.1046/j.0014-2956.2001.02681.x |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode = 2002PNAS...9916899M |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Miyoshi K, Honda A, Baba K |title=Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. |journal=Mol. Psychiatry |volume=8 |issue= 7 |pages= 685–94 |year= 2004 |pmid= 12874605 |doi= 10.1038/sj.mp.4001352 |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Surpili MJ, Delben TM, Kobarg J |title=Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. |journal=Biochemistry |volume=42 |issue= 51 |pages= 15369–76 |year= 2004 |pmid= 14690447 |doi= 10.1021/bi034575v }} *{{cite journal |vauthors=Goehler H, Lalowski M, Stelzl U |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Okumura F, Hatakeyama S, Matsumoto M |title=Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53533–43 |year= 2005 |pmid= 15466860 |doi= 10.1074/jbc.M402916200 |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} *{{cite journal |vauthors=Yamada K, Nakamura K, Minabe Y |title=Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts. |journal=Biol. Psychiatry |volume=56 |issue= 9 |pages= 683–90 |year= 2005 |pmid= 15522253 |doi= 10.1016/j.biopsych.2004.08.015 |s2cid=42525017 |display-authors=etal}} *{{cite journal |vauthors=Stelzl U, Worm U, Lalowski M |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |display-authors=etal|url=http://edoc.mpg.de/get.epl?fid=21592&did=275687&ver=0 |hdl=11858/00-001M-0000-0010-8592-0 |s2cid=8235923 |hdl-access=free }} *{{cite journal |vauthors=Assmann EM, Alborghetti MR, Camargo ME, Kobarg J |title=FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. |journal=J. Biol. Chem. |volume=281 |issue= 15 |pages= 9869–81 |year= 2006 |pmid= 16484223 |doi= 10.1074/jbc.M513280200 |doi-access= free }} *{{cite journal |vauthors=Blasius TL, Cai D, Jih GT |title=Two binding partners cooperate to activate the molecular motor Kinesin-1. |journal=J. Cell Biol. |volume=176 |issue= 1 |pages= 11–7 |year= 2007 |pmid= 17200414 |doi= 10.1083/jcb.200605099 | pmc=2063617 |display-authors=etal}} *{{cite journal |vauthors=Koga M, Ishiguro H, Horiuchi Y |title=Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population. |journal=Neurosci. Lett. |volume=417 |issue= 3 |pages= 326–9 |year= 2007 |pmid= 17374448 |doi= 10.1016/j.neulet.2007.02.055 |s2cid=33689793 |display-authors=etal}} {{refend}}
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