{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Lysyl oxidase homolog 4''' is an enzyme that in humans is encoded by the ''LOXL4'' gene.<ref name="pmid11292829">{{cite journal |vauthors=Ito H, Akiyama H, Iguchi H, Iyama K, Miyamoto M, Ohsawa K, Nakamura T | title = Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage | journal = J Biol Chem | volume = 276 | issue = 26 | pages = 24023–9 |date=Jun 2001 | pmid = 11292829 | doi = 10.1074/jbc.M100861200 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LOXL4 lysyl oxidase-like 4| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=84171}}</ref>
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.<ref name="entrez" />
==See also== * LOXL1 * LOXL2 * LOXL3
==References== {{reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Molnar J, Fong KS, He QP, etal |title=Structural and functional diversity of lysyl oxidase and the LOX-like proteins |journal=Biochim. Biophys. Acta |volume=1647 |issue= 1–2 |pages= 220–4 |year= 2003 |pmid= 12686136 |doi= 10.1016/s1570-9639(03)00053-0}} *{{cite journal |vauthors=Asuncion L, Fogelgren B, Fong KS, etal |title=A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain |journal=Matrix Biol. |volume=20 |issue= 7 |pages= 487–91 |year= 2002 |pmid= 11691588 |doi=10.1016/S0945-053X(01)00161-5 }} *{{cite journal |vauthors=Mäki JM, Tikkanen H, Kivirikko KI |title=Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains |journal=Matrix Biol. |volume=20 |issue= 7 |pages= 493–6 |year= 2002 |pmid= 11691589 |doi=10.1016/S0945-053X(01)00157-3 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Holtmeier C, Görögh T, Beier U, etal |title=Overexpression of a novel lysyl oxidase-like gene in human head and neck squamous cell carcinomas |journal=Anticancer Res. |volume=23 |issue= 3B |pages= 2585–91 |year= 2003 |pmid= 12894545 }} *{{cite journal |vauthors=Kim MS, Kim SS, Jung ST, etal |title=Expression and purification of enzymatically active forms of the human lysyl oxidase-like protein 4 |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52071–4 |year= 2004 |pmid= 14551188 |doi= 10.1074/jbc.M308856200 |doi-access= free }} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }} *{{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }} *{{cite journal |vauthors=Shieh TM, Lin SC, Liu CJ, etal |title=Association of expression aberrances and genetic polymorphisms of lysyl oxidase with areca-associated oral tumorigenesis |journal=Clin. Cancer Res. |volume=13 |issue= 15 Pt 1 |pages= 4378–85 |year= 2007 |pmid= 17671119 |doi= 10.1158/1078-0432.CCR-06-2685 |doi-access= free }} {{refend}}
Category:Lysyl oxidases
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