HOMER3

{{Short description|Protein and coding gene in humans}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Homer protein homolog 3''' is a protein that in humans is encoded by the ''HOMER3'' gene.<ref name="pmid10653696">{{cite journal | vauthors = Soloviev MM, Ciruela F, Chan WY, McIlhinney RA | title = Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing | journal = Journal of Molecular Biology | volume = 295 | issue = 5 | pages = 1185–200 | date = Feb 2000 | pmid = 10653696 | doi = 10.1006/jmbi.1999.3436 }}</ref><ref name="pmid9808459">{{cite journal | vauthors = Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF | title = Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors | journal = Neuron | volume = 21 | issue = 4 | pages = 717–26 | date = Oct 1998 | pmid = 9808459 | doi = 10.1016/S0896-6273(00)80589-9 | s2cid = 2851554 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOMER3 homer homolog 3 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9454}}</ref>

== Function ==

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth.<ref name="entrez" />

== Interactions ==

HOMER3 has been shown to interact with TRPC1<ref name=pmid14505576>{{cite journal | vauthors = Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF | title = Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors | journal = Cell | volume = 114 | issue = 6 | pages = 777–89 | date = Sep 2003 | pmid = 14505576 | doi = 10.1016/S0092-8674(03)00716-5 | s2cid = 10552676 | doi-access = free }}</ref> and RYR1.<ref name=pmid12223488>{{cite journal | vauthors = Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN | title = Homer regulates gain of ryanodine receptor type 1 channel complex | journal = The Journal of Biological Chemistry | volume = 277 | issue = 47 | pages = 44722–30 | date = Nov 2002 | pmid = 12223488 | doi = 10.1074/jbc.M207675200 | doi-access = free }}</ref>

== See also == * HOMER1 * HOMER2

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF | title = Homer: a protein that selectively binds metabotropic glutamate receptors | journal = Nature | volume = 386 | issue = 6622 | pages = 284–8 | date = Mar 1997 | pmid = 9069287 | doi = 10.1038/386284a0 | bibcode = 1997Natur.386..284B | s2cid = 4346579 }} * {{cite journal | vauthors = Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF | title = Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins | journal = Neuron | volume = 21 | issue = 4 | pages = 707–16 | date = Oct 1998 | pmid = 9808458 | doi = 10.1016/S0896-6273(00)80588-7 | s2cid = 16431031 | doi-access = free }} * {{cite journal | vauthors = Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN | title = Homer regulates gain of ryanodine receptor type 1 channel complex | journal = The Journal of Biological Chemistry | volume = 277 | issue = 47 | pages = 44722–30 | date = Nov 2002 | pmid = 12223488 | doi = 10.1074/jbc.M207675200 | doi-access = free }} * {{cite journal | vauthors = Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF | title = Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors | journal = Cell | volume = 114 | issue = 6 | pages = 777–89 | date = Sep 2003 | pmid = 14505576 | doi = 10.1016/S0092-8674(03)00716-5 | s2cid = 10552676 | doi-access = free }} * {{cite journal | vauthors = Ishiguro K, Xavier R | title = Homer-3 regulates activation of serum response element in T cells via its EVH1 domain | journal = Blood | volume = 103 | issue = 6 | pages = 2248–56 | date = Mar 2004 | pmid = 14645007 | doi = 10.1182/blood-2003-08-2671 | doi-access = free }} * {{cite journal | vauthors = Cooper ST, Hanson IM | title = A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11 | journal = BMC Genetics | volume = 6 | article-number = 43 | year = 2006 | pmid = 16098226 | pmc = 1208879 | doi = 10.1186/1471-2156-6-43 | doi-access = free }} * {{cite journal | vauthors = Schreiner D, Müller K, Hofer HW | title = The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins | journal = FEBS Letters | volume = 580 | issue = 22 | pages = 5295–300 | date = Oct 2006 | pmid = 16979624 | doi = 10.1016/j.febslet.2006.08.079 | bibcode = 2006FEBSL.580.5295S | s2cid = 10267922 | doi-access = }} {{refend}}

Category:EVH1 domain