HOMER2

{{Short description|Protein and coding gene in humans}} {{Infobox_gene}} '''Homer protein homolog 2''' is a protein that in humans is encoded by the ''HOMER2'' gene.<ref name="pmid9808459">{{cite journal |vauthors=Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF | title = Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors | journal = Neuron | volume = 21 | issue = 4 | pages = 717–26 |date=Dec 1998 | pmid = 9808459 | doi =10.1016/S0896-6273(00)80589-9 | doi-access = free }}</ref><ref name="pmid9808458">{{cite journal |vauthors=Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF | title = Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins | journal = Neuron | volume = 21 | issue = 4 | pages = 707–16 |date=Dec 1998 | pmid = 9808458 | doi =10.1016/S0896-6273(00)80588-7 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOMER2 homer homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9455}}</ref>

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth. Four transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez" />

==Interactions== HOMER2 has been shown to interact with RYR1.<ref name=pmid12223488>{{cite journal |last=Feng |first=Wei |author2=Tu Jiancheng |author3=Yang Tianzhong |author4=Vernon Patty Shih |author5=Allen Paul D |author6=Worley Paul F |author7=Pessah Isaac N |date=Nov 2002 |title=Homer regulates gain of ryanodine receptor type 1 channel complex |journal=J. Biol. Chem. |volume=277 |issue=47 |pages=44722–30 |location = United States| issn = 0021-9258| pmid = 12223488 |doi = 10.1074/jbc.M207675200 |doi-access=free }}</ref>

==See also== * HOMER1 * HOMER3

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Soloviev MM, Ciruela F, Chan WY, McIlhinney RA |title=Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing. |journal=J. Mol. Biol. |volume=295 |issue= 5 |pages= 1185–200 |year= 2000 |pmid= 10653696 |doi= 10.1006/jmbi.1999.3436 }} *{{cite journal |vauthors=Feng W, Tu J, Yang T, etal |title=Homer regulates gain of ryanodine receptor type 1 channel complex. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 44722–30 |year= 2003 |pmid= 12223488 |doi= 10.1074/jbc.M207675200 |doi-access= free }} *{{cite journal |vauthors=Kim JT, Park SH, Kim SK, etal |title=Potential role of Homer-2a on cutaneous vascular anomaly. |journal=J. Korean Med. Sci. |volume=17 |issue= 5 |pages= 636–40 |year= 2003 |doi=10.3346/jkms.2002.17.5.636 |pmid= 12378015 |pmc=3054924}} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Shiraishi Y, Mizutani A, Mikoshiba K, Furuichi T |title=Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons. |journal=Mol. Cell. Neurosci. |volume=22 |issue= 2 |pages= 188–201 |year= 2003 |pmid= 12676529 |doi=10.1016/S1044-7431(03)00037-X |s2cid=38323844 }} *{{cite journal |vauthors=Rong R, Ahn JY, Huang H, etal |title=PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. |journal=Nat. Neurosci. |volume=6 |issue= 11 |pages= 1153–61 |year= 2003 |pmid= 14528310 |doi= 10.1038/nn1134 |s2cid=807407 }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal |vauthors=Ishibashi T, Ogawa S, Hashiguchi Y, etal |title=A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems. |journal=J. Biochem. |volume=137 |issue= 5 |pages= 617–23 |year= 2005 |pmid= 15944415 |doi= 10.1093/jb/mvi074 |doi-access= free }} *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }} *{{cite journal |vauthors=Dahl JP, Kampman KM, Oslin DW, etal |title=Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. |journal=Psychiatr. Genet. |volume=15 |issue= 4 |pages= 277–83 |year= 2006 |pmid= 16314758 |doi=10.1097/00041444-200512000-00010 |s2cid=24128233 }} {{refend}} {{PDB Gallery|geneid=9455}}