Golgin subfamily A member 2

{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Golgin subfamily A member 2''', also known as '''130 kDa cis-Golgi matrix protein 1''' ('''GM130''') is a protein that in humans is encoded by the ''GOLGA2'' gene.<ref name="pmid8315394">{{cite journal | vauthors = Fritzler MJ, Hamel JC, Ochs RL, Chan EK | title = Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex | journal = The Journal of Experimental Medicine | volume = 178 | issue = 1 | pages = 49–62 | date = Jul 1993 | pmid = 8315394 | pmc = 2191081 | doi = 10.1084/jem.178.1.49 }}</ref>

== Function ==

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis.<ref name="Mascanzoni">{{cite journal |vauthors=Mascanzoni F, Iannitti R, Colanzi A |title=Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle |journal=Cells |volume=11 |issue=3 |date=January 2022 |page=354 |pmid=35159164 |pmc=8834581 |doi=10.3390/cells11030354 |url= |doi-access=free }}</ref> The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: GOLGA2 golgi autoantigen, golgin subfamily a, 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2801}}</ref>

A patient with a neuromuscular disorder has been identified that is homozygous for a deletion mutation in this gene, and morpholino knockdown in zebrafish has shown similar phenotypes.<ref name="pmid26742501">{{cite journal | vauthors = Shamseldin HE, Bennett AH, Alfadhel M, Gupta V, Alkuraya FS | title = GOLGA2, encoding a master regulator of golgi apparatus, is mutated in a patient with a neuromuscular disorder | journal = Human Genetics | volume = 135 | issue = 2 | pages = 245–51 | year = 2016 | pmid = 26742501 | pmc = 4975006 | doi = 10.1007/s00439-015-1632-8 }}</ref>

== Interactions ==

GOLGA2 has been shown to interact with: {{div col|colwidth=20em}} * GORASP1,<ref name = pmid11739401/><ref name = pmid10487747/><ref name = pmid11739402/><ref name = pmid11781572>{{cite journal | vauthors = Marra P, Maffucci T, Daniele T, Tullio GD, Ikehara Y, Chan EK, Luini A, Beznoussenko G, Mironov A, De Matteis MA | title = The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment | journal = Nature Cell Biology | volume = 3 | issue = 12 | pages = 1101–13 | date = Dec 2001 | pmid = 11781572 | doi = 10.1038/ncb1201-1101 | s2cid = 25743225 }}</ref> * GORASP2,<ref name = pmid11739401/><ref name = pmid10487747>{{cite journal | vauthors = Shorter J, Watson R, Giannakou ME, Clarke M, Warren G, Barr FA | title = GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system | journal = The EMBO Journal | volume = 18 | issue = 18 | pages = 4949–60 | date = Sep 1999 | pmid = 10487747 | pmc = 1171566 | doi = 10.1093/emboj/18.18.4949 }}</ref><ref name = pmid11739402>{{cite journal | vauthors = Barr FA, Preisinger C, Kopajtich R, Körner R | title = Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus | journal = The Journal of Cell Biology | volume = 155 | issue = 6 | pages = 885–91 | date = Dec 2001 | pmid = 11739402 | pmc = 2150891 | doi = 10.1083/jcb.200108102 }}</ref> * RAB1A,<ref name = pmid11739401/><ref name = pmid12788069>{{cite journal | vauthors = Weide T, Teuber J, Bayer M, Barnekow A | title = MICAL-1 isoforms, novel rab1 interacting proteins | journal = Biochemical and Biophysical Research Communications | volume = 306 | issue = 1 | pages = 79–86 | date = Jun 2003 | pmid = 12788069 | doi = 10.1016/s0006-291x(03)00918-5}}</ref><ref name = pmid11718716>{{cite journal | vauthors = Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T | title = Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER | journal = FEBS Letters | volume = 508 | issue = 2 | pages = 201–9 | date = Nov 2001 | pmid = 11718716 | doi = 10.1016/s0014-5793(01)02993-3| s2cid = 21545088 | doi-access = free }}</ref> * RAB1B<ref name = pmid11306556>{{cite journal | vauthors = Weide T, Bayer M, Köster M, Siebrasse JP, Peters R, Barnekow A | title = The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b | journal = EMBO Reports | volume = 2 | issue = 4 | pages = 336–41 | date = Apr 2001 | pmid = 11306556 | pmc = 1083862 | doi = 10.1093/embo-reports/kve065 }}</ref> and * RAB2A.<ref name = pmid11739401>{{cite journal | vauthors = Pfeffer SR | title = Constructing a Golgi complex | journal = The Journal of Cell Biology | volume = 155 | issue = 6 | pages = 873–5 | date = Dec 2001 | pmid = 11739400 | pmc = 2150916 | doi = 10.1083/jcb.200109095 }}</ref><ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}</ref> * WAC protein<ref name="pmid26687599">{{cite journal | vauthors = Joachim J, Jefferies HB, Razi M, Frith D, Snijders AP, Chakravarty P, Judith D, Tooze SA | title = Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130 | journal = Molecular Cell | volume = 60 | issue = 6 | pages = 899–913 | year = 2015 | pmid = 26687599 | pmc = 4691241 | doi = 10.1016/j.molcel.2015.11.018 }}</ref> {{Div col end}}

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Nakamura N, Rabouille C, Watson R, Nilsson T, Hui N, Slusarewicz P, Kreis TE, Warren G | title = Characterization of a cis-Golgi matrix protein, GM130 | journal = The Journal of Cell Biology | volume = 131 | issue = 6 Pt 2 | pages = 1715–26 | date = Dec 1995 | pmid = 8557739 | pmc = 2120691 | doi = 10.1083/jcb.131.6.1715 }} * {{cite journal | vauthors = Nakamura N, Lowe M, Levine TP, Rabouille C, Warren G | title = The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner | journal = Cell | volume = 89 | issue = 3 | pages = 445–55 | date = May 1997 | pmid = 9150144 | doi = 10.1016/S0092-8674(00)80225-1 | s2cid = 2135774 | doi-access = free }} * {{cite journal | vauthors = Barr FA, Puype M, Vandekerckhove J, Warren G | title = GRASP65, a protein involved in the stacking of Golgi cisternae | journal = Cell | volume = 91 | issue = 2 | pages = 253–62 | date = Oct 1997 | pmid = 9346242 | doi = 10.1016/S0092-8674(00)80407-9 | s2cid = 11655667 | doi-access = free }} * {{cite journal | vauthors = Sohda M, Misumi Y, Yano A, Takami N, Ikehara Y | title = Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane | journal = The Journal of Biological Chemistry | volume = 273 | issue = 9 | pages = 5385–8 | date = Feb 1998 | pmid = 9478999 | doi = 10.1074/jbc.273.9.5385 | doi-access = free }} * {{cite journal | vauthors = Barr FA, Nakamura N, Warren G | title = Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae | journal = The EMBO Journal | volume = 17 | issue = 12 | pages = 3258–68 | date = Jun 1998 | pmid = 9628863 | pmc = 1170664 | doi = 10.1093/emboj/17.12.3258 }} * {{cite journal | vauthors = Lowe M, Rabouille C, Nakamura N, Watson R, Jackman M, Jämsä E, Rahman D, Pappin DJ, Warren G | title = Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis | journal = Cell | volume = 94 | issue = 6 | pages = 783–93 | date = Sep 1998 | pmid = 9753325 | doi = 10.1016/S0092-8674(00)81737-7 | s2cid = 10765081 | doi-access = free }} * {{cite journal | vauthors = Barr FA | title = A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins | journal = Current Biology | volume = 9 | issue = 7 | pages = 381–4 | date = Apr 1999 | pmid = 10209123 | doi = 10.1016/S0960-9822(99)80167-5 | s2cid = 14404566 | doi-access = free | bibcode = 1999CBio....9..381B }} * {{cite journal | vauthors = Shorter J, Watson R, Giannakou ME, Clarke M, Warren G, Barr FA | title = GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system | journal = The EMBO Journal | volume = 18 | issue = 18 | pages = 4949–60 | date = Sep 1999 | pmid = 10487747 | pmc = 1171566 | doi = 10.1093/emboj/18.18.4949 }} * {{cite journal | vauthors = Bouchireb N, Clark MS | title = Human golgin-95 gene (GOLGA2). Map position 9q32-34.1 | journal = Chromosome Research | volume = 7 | issue = 6 | pages = 501 | year = 1999 | pmid = 10560974 | doi = 10.1023/A:1009210232273 | s2cid = 28928573 }} * {{cite journal | vauthors = Linstedt AD, Jesch SA, Mehta A, Lee TH, Garcia-Mata R, Nelson DS, Sztul E | title = Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminus | journal = The Journal of Biological Chemistry | volume = 275 | issue = 14 | pages = 10196–201 | date = Apr 2000 | pmid = 10744704 | doi = 10.1074/jbc.275.14.10196 | doi-access = free }} * {{cite journal | vauthors = Lowe M, Gonatas NK, Warren G | title = The mitotic phosphorylation cycle of the cis-Golgi matrix protein GM130 | journal = The Journal of Cell Biology | volume = 149 | issue = 2 | pages = 341–56 | date = Apr 2000 | pmid = 10769027 | pmc = 2175168 | doi = 10.1083/jcb.149.2.341 }} * {{cite journal | vauthors = Alvarez C, Garcia-Mata R, Hauri HP, Sztul E | title = The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic | journal = The Journal of Biological Chemistry | volume = 276 | issue = 4 | pages = 2693–700 | date = Jan 2001 | pmid = 11035033 | doi = 10.1074/jbc.M007957200 | doi-access = free }} * {{cite journal | vauthors = Moyer BD, Allan BB, Balch WE | title = Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering | journal = Traffic | volume = 2 | issue = 4 | pages = 268–76 | date = Apr 2001 | pmid = 11285137 | doi = 10.1034/j.1600-0854.2001.1o007.x | s2cid = 43069518 | doi-access = free }} * {{cite journal | vauthors = Weide T, Bayer M, Köster M, Siebrasse JP, Peters R, Barnekow A | title = The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b | journal = EMBO Reports | volume = 2 | issue = 4 | pages = 336–41 | date = Apr 2001 | pmid = 11306556 | pmc = 1083862 | doi = 10.1093/embo-reports/kve065 }} * {{cite journal | vauthors = Puthenveedu MA, Linstedt AD | title = Evidence that Golgi structure depends on a p115 activity that is independent of the vesicle tether components giantin and GM130 | journal = The Journal of Cell Biology | volume = 155 | issue = 2 | pages = 227–38 | date = Oct 2001 | pmid = 11591729 | pmc = 2198842 | doi = 10.1083/jcb.200105005 }} * {{cite journal | vauthors = Miles S, McManus H, Forsten KE, Storrie B | title = Evidence that the entire Golgi apparatus cycles in interphase HeLa cells: sensitivity of Golgi matrix proteins to an ER exit block | journal = The Journal of Cell Biology | volume = 155 | issue = 4 | pages = 543–55 | date = Nov 2001 | pmid = 11696556 | pmc = 2198853 | doi = 10.1083/jcb.200103104 }} * {{cite journal | vauthors = Majoul I, Straub M, Hell SW, Duden R, Söling HD | title = KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET | journal = Developmental Cell | volume = 1 | issue = 1 | pages = 139–53 | date = Jul 2001 | pmid = 11703931 | doi = 10.1016/S1534-5807(01)00004-1 | doi-access = free }} * {{cite journal | vauthors = Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T | title = Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER | journal = FEBS Letters | volume = 508 | issue = 2 | pages = 201–9 | date = Nov 2001 | pmid = 11718716 | doi = 10.1016/S0014-5793(01)02993-3 | s2cid = 21545088 | doi-access = free }} * {{cite journal | vauthors = Short B, Preisinger C, Körner R, Kopajtich R, Byron O, Barr FA | title = A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic | journal = The Journal of Cell Biology | volume = 155 | issue = 6 | pages = 877–83 | date = Dec 2001 | pmid = 11739401 | pmc = 2150909 | doi = 10.1083/jcb.200108079 }} {{refend}}

{{Commons category|GM130}}