{{Short description|Family of bacteria}} {{Automatic taxobox | image = | image_caption = | parent_authority = Gupta ''et al''. 2013 | taxon = Eggerthellaceae | authority = Gupta ''et al''. 2013<ref name="Gupta">{{cite journal |vauthors=Gupta RS, Chen WJ, Adeolu M, Chai Y | title = Molecular signatures for the class ''Coriobacteriia'' and its different clades; Proposal for division of the class ''Coriobacteriia'' into the emended order ''Coriobacteriales'', containing the emended family ''Coriobacteriaceae'' and ''Atopobiaceae'' fam. nov., and ''Eggerthellales'' ord. nov., containing the family ''Eggerthellaceae'' fam. nov. | journal = Int J Syst Evol Microbiol | year = 2013 | volume = 63 | issue = Pt 9 | pages = 3379–3397| doi = 10.1099/ijs.0.048371-0 | pmid = 23524353 }}</ref><ref name=LPSN/> | subdivision_ranks = Genera | subdivision_ref = <ref name=NCBI/> | subdivision = See text }}
The '''Eggerthellaceae''' are a family of Gram-positive, rod- or coccus-shaped Actinomycetota.<ref name="Gupta"/> It is the sole family within the order '''Eggerthellales'''.<ref name=LPSN/>
The name ''Eggerthellaceae'' is derived from the Latin term ''Eggerthella,'' referring to the type genus of the family and the suffix "-ceae," an ending used to denote a family. Together, ''Eggerthellaceae'' refers to a family whose nomenclatural type is the genus ''Eggerthella''.<ref name=":0">{{Citation|last=Gupta|first=Radhey S.|editor1-first=Lorena|editor1-last=Carro|title=Eggerthellaceae|date=2021|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/9781118960608.fbm00384|work=Bergey's Manual of Systematics of Archaea and Bacteria|pages=1–11|publisher=American Cancer Society|language=en|doi=10.1002/9781118960608.fbm00384|isbn=978-1-118-96060-8|s2cid=243126790 |access-date=2021-07-05|url-access=subscription}}</ref>
== Biochemical characteristics and molecular signatures == Members of this family are mostly anaerobic, non-motile (with the exception of some ''Gordonibacter'' and ''Senegalimassilia'' species that exhibit motility), asaccharolytic and do not form spores.<ref name=":0" /> ''Eggerthellaceae'' species are commonly isolated from human and animal faeces and other human sources such as the colon, vagina, oral cavity and blood.<ref name=":0" /> Some species have also been isolated from human samples of periodontal or endodontic infections, Crohn's disease and severe blood bacteremia.<ref name=":0" /> The G+C content for ''Eggerthellaceae'' species is between 43.4 and 66.3 mol%.<ref name=":0" />
Analysis of genome sequences identified 13 conserved signature indels (CSIs) in diverse proteins that are exclusively present in different ''Eggerthellaceae'' species. The proteins containing these CSIs are: excinuclease ABC subunit UvrC, DNA polymerase III subunit alpha, ribonuclease III, tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase (MiaB), peptide chain release factor 2, 16S rRNA (cytosine(1402)-N(4))-methyltransferase, elongation factor Tu, UDP-N-acetylglucosamine 1-carboxyvinyltransferase DNA polymerase III subunit epsilon, UDP-glucose 4-epimerase and DNA-directed RNA polymerase subunit alpha.<ref name="Gupta" /><ref name=":0" /> The identified CSIs provide reliable and important means to distinguish members of ''Eggerthellaceae'' from all other Coriobacteriia as well as other bacteria.
==Phylogeny== The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN)<ref name=LPSN>{{lpsn3|family/eggerthellaceae|Eggerthellaceae}}</ref> and National Center for Biotechnology Information (NCBI).<ref name=NCBI>{{cite web |author=C.L. Schoch |url=https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?command=show&mode=tree&id=1643826&lvl=3 |title=Eggerthellaceae |access-date=2025-02-28 |publisher=National Center for Biotechnology Information (NCBI) taxonomy database |display-authors=et al.}}</ref>
{| class="wikitable" |- ! colspan=1 | Nouioui et al. 2018<ref name="Nouioui">{{cite journal |vauthors=Nouioui I, Carro L, García-López M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Markus Göker M | year = 2018 | title = Genome-Based Taxonomic Classification of the Phylum ''Actinobacteria'' | journal = Front. Microbiol. | volume = 9 | pages = 2007 | pmid = 30186281 | pmc = 6113628 | doi = 10.3389/fmicb.2018.02007| doi-access = free}}</ref>{{efn|''Asaccharobacter'', ''Ellagibacter'', ''Enteroscipio'', ''Paraeggerthella'', and ''Rubneribacter'' are not included in this phylogenetic tree.}} ! colspan=1 | conserved signature indels by Gupta & Carro 2021<ref name=":0" /> |- | style="vertical-align:top| {{Clade | style=font-size:90%;line-height:80% |1={{clade |1=Coriobacteriales |2={{clade |label1=Eggerthellales |1={{clade |1=''Slackia'' |2={{clade |1={{clade |1=''Cryptobacterium'' |2=''Denitrobacterium'' }} |2={{clade |1={{clade |1=''Senegalimassilia'' |2={{clade |1=''Eggerthella'' |2=''Gordonibacter'' }} }} |2=''Adlercreutzia'' }} }} }} }} }} }} | {{Clade | style=font-size:90%;line-height:80% thumb }} |}
{| class="wikitable" |- ! colspan=1 | 16S rRNA based LTP_10_2024<ref>{{cite web |title=The LTP |url=https://imedea.uib-csic.es/mmg/ltp/#LTP| access-date=10 December 2024}}</ref><ref>{{cite web |title=LTP_all tree in newick format |url=https://imedea.uib-csic.es/mmg/ltp/wp-content/uploads/ltp/LTP_all_10_2024.ntree |access-date=10 December 2024}}</ref><ref>{{cite web |title=LTP_10_2024 Release Notes |url=https://imedea.uib-csic.es/mmg/ltp/wp-content/uploads/ltp/LTP_10_2024_release_notes.pdf |access-date=10 December 2024}}</ref> ! colspan=1 | 120 marker proteins based GTDB 10-RS226<ref name="about">{{cite web |title=GTDB release 10-RS226 |url=https://gtdb.ecogenomic.org/about#4%7C |website=Genome Taxonomy Database|access-date=1 May 2025}}</ref><ref name="tree_bac">{{cite web |title=bac120_r226.sp_label |url=https://data.gtdb.ecogenomic.org/releases/release226/226.0/auxillary_files/bac120_r226.sp_labels.tree |website=Genome Taxonomy Database|access-date=1 May 2025}}</ref><ref name="taxon_history">{{cite web |title=Taxon History |url=https://gtdb.ecogenomic.org/taxon_history/ |website=Genome Taxonomy Database|access-date=1 May 2025}}</ref> |- | style="vertical-align:top| {{Clade | style=font-size:90%;line-height:80% |1={{clade |1={{clade |label1=Eggerthellaceae~ |1={{clade |1=''Anaerotardibacter'' |2=''Raoultibacter'' }} }} |2={{clade |1=Atopobiaceae |2={{clade |1={{clade |label1=Eggerthellaceae~ |1={{clade |1=''Cryptobacterium'' |2={{clade |1=''Curtanaerobium'' |2=''Denitrobacterium'' }} }} }} |2={{clade |1={{clade |1=''Slackia'' |2=Coriobacteriaceae }} |2={{clade |label1=Eggerthellaceae |1={{clade |1={{clade |1=''Ellagibacter'' |2=''Senegalimassilia'' }} |2={{clade |1={{clade |1=''Berryella'' |2=''Adlercreutzia'' [incl. ''Parvibacter''] }} |2={{clade |1={{clade |1=''Rubneribacter'' |2=''Xiamenia'' }} |2={{clade |1={{clade |1=''Adlercreutzia agrestimuris'' <small>Afrizal et al. 2023</small> |2=''Enteroscipio'' }} |2={{clade |1=''Arabiibacter'' |2={{clade |1=''Paraeggerthella'' |2={{clade |1=''Gordonibacter'' |2=''Eggerthella'' }} }} }} }} }} }} }} }} }} }} }} }} }} | {{Clade | style=font-size:90%;line-height:80% |1={{clade |2={{clade |1=Coriobacteriaceae |2=Atopobiaceae }} |1={{clade |label1=Eggerthellaceae |1={{clade |1="''Phoenicibacter''" <small>Bilen et al. 2019</small> |2={{clade |1=''Berryella'' <small>Wylensek et al. 2021</small> |2={{clade |1={{clade |1={{clade |1="''Ca.'' Aveggerthella" <small>Gilroy et al. 2021</small> |2=''Raoultibacter'' <small>Traore et al. 2022</small> }} |2={{clade |1=''Slackia'' <small>Wade et al. 1999</small> |2={{clade |1=''Anaerotardibacter'' <small>Afrizal et al. 2024</small> |2={{clade |1={{clade |1=''Cryptobacterium'' <small>Nakazawa et al. 1999</small> |2="''Hugonella''" <small>Elsawi et al. 2017</small> }} |2={{clade |1=''Curtanaerobium'' <small>Sun et al. 2023</small> |2=''Denitrobacterium'' <small>Anderson et al. 2000</small> }} }} }} }} }} |2={{clade |1={{clade |1=''Ellagibacter'' <small>Beltran et al. 2018</small> |2=''Senegalimassilia'' <small>corrig. Lagier et al. 2014</small> }} |2={{clade |1={{clade |1="''Ca.'' Aphodovivens" <small>Gilroy et al. 2021</small> |2={{clade |1={{clade |1="''Adlercreutzia murintestinalis''" <small>Afrizal et al. 2022</small> |2=''Parvibacter'' <small>Clavel et al. 2013</small> }} |2=''Adlercreutzia'' <small>Maruo et al. 2008</small> }} }} |2={{clade |1=''Xiamenia'' <small>Zhang et al. 2022</small> |2={{clade |1=''Gordonibacter'' <small>Wurdemann et al. 2009</small> |2={{clade |1=''Enteroscipio'' <small>Danylec et al. 2018</small> |2={{clade |1={{clade |1=''Arabiibacter'' <small>Lo et al. 2023</small> |2=''Rubneribacter'' <small>Danylec et al. 2018</small> }} |2={{clade |1=''Paraeggerthella'' <small>Wurdemann et al. 2009</small> |2=''Eggerthella'' <small>Wade et al. 1999</small> }} }} }} }} }} }} }} }} }} }} }} }} }} |} Genera incertae sedis: * "''Allenteromonas''" <small>Liu et al. 2020</small> * "''Mucirhabdus''" <small>Liu et al. 2020</small> * "''Stereobacter''" <small>Liu et al. 2020</small> * "''Stereobacterium''" <small>Liu et al. 2020</small> * ''Umbribacter'' <small>Srinivasan et al. 2025</small>
==Notes== {{notelist}}
==References== {{Reflist}}
{{Bacteria classification}} {{Taxonbar|from1=Q26211110|from2=Q26211121}}
Category:Actinomycetota Category:Bacteria families Category:Long stubs with short prose
{{Actinobacteria-stub}}