{{Short description|American neuropathologist (1935–2023)}} '''Donald Lowell Price''' (June 16, 1935 – May 5, 2023) was an American neuropathologist and professor at the Johns Hopkins School of Medicine. His research aimed to understand the molecular basis of neurodegenerative diseases, particularly Alzheimer's disease. Price received a number of awards for his work and served as the President of both the American Association of Neuropathologists and the Society for Neuroscience. <ref name=":0">{{Cite web|url=http://pathology.jhu.edu/department/priceResearchFund.pdf|title=The Donald L. Price Research Fund|date=May 18, 2008|website=Johns Hopkins Medicine}}</ref>
== Background == Price was born in Stamford, Connecticut on June 16, 1935. He attended Wesleyan University, where he received a Bachelor of Arts in English Literature. In 1961, he received his medical degree from Albany Medical College of Union University. Following graduation, Dr. Price was a Medical Intern and Resident at the New England Medical Center, Boston, MA ( 1961–1963), and he completed a Neurology Residency at the Massachusetts General Hospital, Boston, MA (1963-1968). He was a Staff Neurologist at the National Naval Medical Center in Bethesda, Maryland (1966–1968). He returned to Boston as a Senior Fellow in Neuropathology at Mass General (1968–1969) and as a Research Fellow in Cell/Molecular Biology (with Keith Porter)(1969-1970) at Harvard University.<ref name=Priceobit/> Price died after a long illness on May 5, 2023, at the age of 87.<ref name=Priceobit>{{Cite web|url=https://www.legacy.com/us/obituaries/washingtonpost/name/donald-price-obituary?id=52138748|title=Donald Price Obituary|website=Legacy.com }}</ref>
== Career == Price's first faculty appointment was as an assistant professor in the Departments of Neurology and Pathology at Harvard Medical School in 1970. In 1971, he was recruited to the Johns Hopkins School of Medicine, becoming the Founding Director of the Division of Neuropathology. At Hopkins, Price was a professor of pathology, Neurology, and Neuroscience.
Price served as President of the American Association of Neuropathologists from 1989 to 1990.<ref>{{Cite web|url=https://www.neuropath.org/past-presidents|title=Past Presidents and Officers|website=www.neuropath.org|access-date=2020-03-30}}</ref> From 2000 to 2001, he served as President of the Society for Neuroscience. Price was a member of The Institute of Medicine (National Academy of Sciences)(1998).<ref>{{Cite web|url=https://www.sfn.org/about/volunteer-leadership/sfn-presidents|title=SfN Presidents|website=www.sfn.org|language=en|access-date=2020-03-30}}</ref>
Over the course of his career, Price trained hundreds of medical and graduate students, house officers and postdoctoral fellows. His trainees include many prominent basic scientists and clinicians at a variety of medical schools, universities, and government institutions.<ref>{{Cite web|url=https://neurotree.org/beta/tree.php?pid=14831&cnodecount=3&pnodecount=4|title=Neurotree - Donald L. Price Family Tree}}</ref> During the "Decade of the Brain" (1990-2000), Price was ranked among the top ten neuroscientists as authors of high-impact papers in neuroscience by Science Watch (12 102 2001).
== Research == Price first focused on the biology of motor neurons, but later in his career, he became interested in brain mechanisms underlying neurodegenerative diseases, particularly [Alzheimer's disease]".<ref name=":1">{{Cite journal|last=Troncoso|first=Juan|date=2012-11-01|title=Meritorious Contributions to Neuropathology|journal=Journal of Neuropathology & Experimental Neurology|language=en|volume=71|issue=11|pages=1030–1031|doi=10.1097/NEN.0b013e318273643e|issn=0022-3069|doi-access=free}}</ref> He often used animal models in order to "allow a more direct insight into pathogenesis", in parallel with comparative analyses of disease in humans. His work with transgenic mice sought to experimentally test new treatment mechanisms before they reached human subjects.<ref>{{Cite journal|last1=Price|first1=D. L.|last2=Tanzi|first2=R. E.|last3=Borchelt|first3=D. R.|last4=Sisodia|first4=S. S.|date=1998|title=Alzheimer's disease: genetic studies and transgenic models|journal=Annual Review of Genetics|volume=32|pages=461–493|doi=10.1146/annurev.genet.32.1.461|issn=0066-4197|pmid=9928488}}</ref> These studies identified specific genes that are often risk factors, particularly genes related to the generation and aggregation of Amyloid beta, a key component of Abeta plaques in the brain. thumb|Defects in the Brain due to Alzheimer's disease|319x319px In 1985, Price became Principal Investigator of the Alzheimer's Disease Research Center at Johns Hopkins University, one of the first federally funded Alzheimer's Disease Research Centers in the United States.
== Awards and honors == {| class="wikitable" |- ! Year !! Award/Honor |- | 1989 || Metropolitan Life Foundation Award<ref>{{Cite web|url=http://mlfawards.afar.org/winners.php|title=Winners {{!}} MetLife Foundation Awards in Medical Research|website=mlfawards.afar.org|access-date=2020-03-30|archive-date=2012-01-23|archive-url=https://web.archive.org/web/20120123033126/http://mlfawards.afar.org/winners.php}}</ref> |- | 1990 || President of the American Association of Neuropathologists |-1991 Soriano Award for Outstanding Contribution to Neuroscience | 1992 || Potamkin Prize for Alzheimer's Disease Research |- | 1994 || Leadership in Alzheimer's Disease (LEAD) Award (National Institute of Aging) |- | 2000-2001 || President of the Society for Neuroscience |- | 2001 || Wartenberg Award<ref>{{Cite web|url=https://www.aan.com/conferences-community/annual-meeting/program/browse-plenary-sessions/plenary-history/|title=Plenary History|website=www.aan.com|language=en|access-date=2020-03-30}}</ref> |- | 2012 || The Award for Meritorious Contributions to Neuropathology<ref name=":1" /> |- | 2015 || AAIC Lifetime Achievement Awards in Alzheimer's Disease<ref>{{Cite web|url=http://alz.org/aaic/about/award-lifetime-list.asp|title=AAIC 2019 - Awards|date=2016-03-18|website=AAIC|language=en|access-date=2020-03-30}}</ref> |- |1986 2000|| 2 Javits Neuroscience Investigator Merit Awards (National Institute of Neurological Disorders and Stroke)<ref name=":0" /> |}
== Publications == Below are some of Price's highly cited publications:<ref name=":1" />
* {{cite book|doi=10.1201/9780429260353-17|chapter-url=https://www.researchgate.net/publication/334079755|chapter=Pathology, Neurobiology, and Animal Models of Alzheimer's Disease|title=Alzheimer's Disease|year=2019|last1=Troncoso|first1=Juan C.|last2=Crain|first2=Barbara J.|last3=Sisodia|first3=Sangram S.|last4=Price|first4=Donald L.|pages=125–144|isbn=978-0-429-26035-3|s2cid=243260534 }} * {{cite book|doi=10.1016/B978-0-12-398270-4.00021-5|chapter-url=https://www.researchgate.net/publication/282594766|chapter=Alzheimer Disease|title=Neurobiology of Brain Disorders|year=2015|last1=Savonenko|first1=Alena V.|last2=Melnikova|first2=Tatiana|last3=Li|first3=Tong|last4=Price|first4=Donald L.|last5=Wong|first5=Philip C.|pages=321–338|isbn=978-0-12-398270-4}} *{{cite book|doi=10.1016/B978-0-12-374947-5.00045-6|chapter=Motor Neuron Diseases|title=Basic Neurochemistry|year=2012|last1=Wong|first1=Philip C.|last2=Chiang|first2=Po-Min|last3=Martin|first3=Lee J.|last4=Koliatsos|first4=Vassilis|last5=Price|first5=Donald L.|pages=801–814|isbn=978-0-12-374947-5}} *{{cite journal|doi=10.1016/j.brainres.2012.04.031|title=Rodent models of TDP-43: Recent advances|year=2012|last1=Tsao|first1=William|last2=Jeong|first2=Yun Ha|last3=Lin|first3=Sophie|last4=Ling|first4=Jonathan|last5=Price|first5=Donald L.|last6=Chiang|first6=Po-Min|last7=Wong|first7=Philip C.|journal=Brain Research|volume=1462|pages=26–39|pmid=22608070|pmc=3613131}} *{{cite journal|doi=10.1371/journal.pone.0028179|title=Increased Expression of PS1 is Sufficient to Elevate the Level and Activity of γ-Secretase in Vivo|year=2011|last1=Li|first1=Tong|last2=Li|first2=Yue-Ming|last3=Ahn|first3=Kwangwook|last4=Price|first4=Donald L.|last5=Sisodia|first5=Sangram S.|last6=Wong|first6=Philip C.|journal=PLOS ONE|volume=6|issue=11|article-number=e28179|pmid=22140537|pmc=3226664|bibcode=2011PLoSO...628179L|doi-access=free }} *{{cite journal|doi=10.1523/JNEUROSCI.6810-10.2011|title=Reduced BACE1 Activity Enhances Clearance of Myelin Debris and Regeneration of Axons in the Injured Peripheral Nervous System|year=2011|last1=Farah|first1=M. H.|last2=Pan|first2=B. H.|last3=Hoffman|first3=P. N.|last4=Ferraris|first4=D.|last5=Tsukamoto|first5=T.|last6=Nguyen|first6=T.|last7=Wong|first7=P. C.|last8=Price|first8=D. L.|last9=Slusher|first9=B. S.|last10=Griffin|first10=J. W.|journal=Journal of Neuroscience|volume=31|issue=15|pages=5744–5754|pmid=21490216|pmc=3302726}} *{{cite journal|doi=10.1073/pnas.91.17.8292|title=Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity|year=1994|last1=Borchelt|first1=D. R.|last2=Lee|first2=M. K.|last3=Slunt|first3=H. S.|last4=Guarnieri|first4=M.|last5=Xu|first5=Z. S.|last6=Wong|first6=P. C.|last7=Brown|first7=R. H.|last8=Price|first8=D. L.|last9=Sisodia|first9=S. S.|last10=Cleveland|first10=D. W.|journal=Proceedings of the National Academy of Sciences|volume=91|issue=17|pages=8292–8296|pmid=8058797|pmc=44592|bibcode=1994PNAS...91.8292B|doi-access=free }}
== References == {{Reflist}}
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{{DEFAULTSORT:Price, Donald}} Category:1935 births Category:2023 deaths Category:American neuropathologists Category:Harvard University alumni Category:Harvard Medical School faculty Category:People from Stamford, Connecticut Category:Wesleyan University alumni Category:Albany Medical College alumni Category:Johns Hopkins University faculty Category:Presidents of the Society for Neuroscience