CtRNA

{{Infobox rfam | Name = ctRNA | image = RF00489.jpg | width = | caption = Predicted secondary structure and sequence conservation of ctRNA_p42d | Symbol = ctRNA_p42d | AltSymbols = | Rfam = RF00489 | miRBase = | miRBase_family = | RNA_type = Gene; antisense | Tax_domain = Bacteria | GO = | SO = {{SO|0000644}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }}

In molecular biology '''ctRNA''' (counter-transcribed RNA) is a plasmid encoded noncoding RNA that binds to the mRNA of {{chem name|repB}} and causes translational inhibition.<ref name="Ven03">{{cite journal | last = Venkova-Canova | first = T |author2=Patek M |author3=Nesvera J | year = 2003 | title = Control of rep gene expression in plasmid pGA1 from Corynebacterium glutamicum | journal = J Bacteriol | volume = 185 | pages = 2402–2409 | pmid = 12670963 | doi = 10.1128/JB.185.8.2402-2409.2003 | issue = 8 | pmc = 152619}}</ref> ctRNA is encoded by plasmids and functions in rolling circle replication to maintain a low copy number. In ''Corynebacterium glutamicum'', it achieves this by antisense pairing with the mRNA of {{chem name|RepB}}, a replication initiation protein.<ref name="Ven03" /> In ''Enterococcus faecium'' the plasmid pJB01 contains three open reading frames, copA, {{chem name|repB}}, and {{chem name|repC}}. The pJB01 ctRNA is coded on the opposite strand from the {{chem name|copA}}/{{chem name|repB}} intergenic region and partially overlaps an atypical ribosome binding site for {{chem name|repB}}.<ref name="pmid18511887">{{cite journal |vauthors=Kim SW, Jeong IS, Jeong EJ |title=The terminal and internal hairpin loops of the ctRNA of plasmid pJB01 play critical roles in regulating copy number |journal=Mol. Cells |volume=26 |issue=1 |pages=26–33 |date=July 2008 |pmid=18511887 |display-authors=etal}}</ref>

==See also== *S-element

==References== {{reflist}}

==External links== * {{Rfam|id=RF00236|name=ctRNA_pGA1}} * {{Rfam|id=RF00489|name=ctRNA_p42d}} * {{Rfam|id=RF00238|name=ctRNA_pND324}} * {{Rfam|id=RF00242|name=ctRNA_pT181}}

Category:Antisense RNA Category:Genetics techniques