AKR1C1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Aldo-keto reductase family 1 member C1''' also known as '''20α-hydroxysteroid dehydrogenase''', '''3α-hydroxysteroid dehydrogenase''', and '''dihydrodiol dehydrogenase 1/2''' is an enzyme that in humans is encoded by the ''AKR1C1'' gene.<ref name="pmid8011662">{{cite journal | vauthors = Ciaccio PJ, Tew KD | title = cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase | journal = Biochimica et Biophysica Acta (BBA) - Bioenergetics | volume = 1186 | issue = 1–2 | pages = 129–32 | date = Jun 1994 | pmid = 8011662 | doi = 10.1016/0005-2728(94)90144-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1645}}</ref>

==Superfamily of enzymes== This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This specific enzyme, AKR1C1, among other reactions, catalyzes the reduction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. The ''AKR1C1'' gene shares high sequence identity with three other gene members, and is clustered with those three genes at chromosome 10p15-p14.<ref name="entrez"/>

==Isozymes of aldo-keto reductase family 1 member C== {{AKR1CN}}

== References == {{reflist}}

== See also ==

* 3α-Hydroxysteroid dehydrogenase

==External links== * {{UCSC gene info|AKR1C1}} * {{UCSC gene info|C9}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Ciaccio PJ, Jaiswal AK, Tew KD | title = Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics | journal = The Journal of Biological Chemistry | volume = 269 | issue = 22 | pages = 15558–62 | date = Jun 1994 | doi = 10.1016/S0021-9258(17)40716-2 | pmid = 7515059 | doi-access = free }} * {{cite journal | vauthors = Khanna M, Qin KN, Cheng KC | title = Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans | journal = The Journal of Steroid Biochemistry and Molecular Biology | volume = 53 | issue = 1–6 | pages = 41–6 | date = Jun 1995 | pmid = 7626489 | doi = 10.1016/0960-0760(95)00019-V | s2cid = 11316547 | doi-access = free }} * {{cite journal | vauthors = Khanna M, Qin KN, Klisak I, Belkin S, Sparkes RS, Cheng KC | title = Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization | journal = Genomics | volume = 25 | issue = 2 | pages = 588–90 | date = Jan 1995 | pmid = 7789999 | doi = 10.1016/0888-7543(95)80066-U | doi-access = free }} * {{cite journal | vauthors = Lou H, Hammond L, Sharma V, Sparkes RS, Lusis AJ, Stolz A | title = Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding | journal = The Journal of Biological Chemistry | volume = 269 | issue = 11 | pages = 8416–22 | date = Mar 1994 | doi = 10.1016/S0021-9258(17)37210-1 | pmid = 8132567 | doi-access = free }} * {{cite journal | vauthors = Deyashiki Y, Ogasawara A, Nakayama T, Nakanishi M, Miyabe Y, Sato K, Hara A | title = Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder | journal = The Biochemical Journal | volume = 299 | issue = 2 | pages = 545–52 | date = Apr 1994 | pmid = 8172617 | pmc = 1138306 | doi = 10.1042/bj2990545}} * {{cite journal | vauthors = Qin KN, New MI, Cheng KC | title = Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase | journal = The Journal of Steroid Biochemistry and Molecular Biology | volume = 46 | issue = 6 | pages = 673–9 | date = Dec 1993 | pmid = 8274401 | doi = 10.1016/0960-0760(93)90308-J | s2cid = 36210133 }} * {{cite journal | vauthors = Stolz A, Hammond L, Lou H, Takikawa H, Ronk M, Shively JE | title = cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family | journal = The Journal of Biological Chemistry | volume = 268 | issue = 14 | pages = 10448–57 | date = May 1993 | doi = 10.1016/S0021-9258(18)82220-7 | pmid = 8486699 | doi-access = free }} * {{cite journal | vauthors = Hara A, Matsuura K, Tamada Y, Sato K, Miyabe Y, Deyashiki Y, Ishida N | title = Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells | journal = The Biochemical Journal | volume = 313 | issue = 2 | pages = 373–6 | date = Jan 1996 | pmid = 8573067 | pmc = 1216918 | doi = 10.1042/bj3130373}} * {{cite journal | vauthors = O'connor T, Ireland LS, Harrison DJ, Hayes JD | title = Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members | journal = The Biochemical Journal | volume = 343 | issue = 2 | pages = 487–504 | date = Oct 1999 | pmid = 10510318 | pmc = 1220579 | doi = 10.1042/bj3430487 }} * {{cite journal | vauthors = Nishizawa M, Nakajima T, Yasuda K, Kanzaki H, Sasaguri Y, Watanabe K, Ito S | title = Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes | journal = Genes to Cells | volume = 5 | issue = 2 | pages = 111–25 | date = Feb 2000 | pmid = 10672042 | doi = 10.1046/j.1365-2443.2000.00310.x | s2cid = 25136637 | doi-access = free }} * {{cite journal | vauthors = Zhang Y, Dufort I, Rheault P, Luu-The V | title = Characterization of a human 20alpha-hydroxysteroid dehydrogenase | journal = Journal of Molecular Endocrinology | volume = 25 | issue = 2 | pages = 221–8 | date = Oct 2000 | pmid = 11013348 | doi = 10.1677/jme.0.0250221 | doi-access = free }} * {{cite journal | vauthors = Nahoum V, Gangloff A, Legrand P, Zhu DW, Cantin L, Zhorov BS, Luu-The V, Labrie F, Breton R, Lin SX | title = Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution | journal = The Journal of Biological Chemistry | volume = 276 | issue = 45 | pages = 42091–8 | date = Nov 2001 | pmid = 11514561 | doi = 10.1074/jbc.M105610200 | doi-access = free }} * {{cite journal | vauthors = Chen CY, Hsu CP, Hsu NY, Shih CS, Lin TY, Chow KC | title = Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer | journal = Oncology Reports | volume = 9 | issue = 3 | pages = 515–9 | year = 2002 | pmid = 11956619 | doi = 10.3892/or.9.3.515 }} * {{cite journal | vauthors = Yang MD, Wu CC, Chiou SH, Chiu CF, Lin TY, Chiang IP, Chow KC | title = Reduction of dihydrodiol dehydrogenase expression in resected hepatocellular carcinoma | journal = Oncology Reports | volume = 10 | issue = 2 | pages = 271–6 | year = 2003 | pmid = 12579257 | doi = 10.3892/or.10.2.271 }} * {{cite journal | vauthors = Nakajima T, Yasuda K, Nishizawa M, Okada H, Yoshimura T, Ito S, Kanzaki H | title = Expression of 20alpha-hydroxysteroid dehydrogenase mRNA in human endometrium and decidua | journal = Endocrine Journal | volume = 50 | issue = 1 | pages = 105–11 | date = Feb 2003 | pmid = 12733716 | doi = 10.1507/endocrj.50.105 | doi-access = free }} * {{cite journal | vauthors = Couture JF, Legrand P, Cantin L, Luu-The V, Labrie F, Breton R | title = Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids | journal = Journal of Molecular Biology | volume = 331 | issue = 3 | pages = 593–604 | date = Aug 2003 | pmid = 12899831 | doi = 10.1016/S0022-2836(03)00762-9 }} * {{cite journal | vauthors = Agapova OA, Yang P, Wang WH, Lane DA, Clark AF, Weinstein BI, Hernandez MR | title = Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes | journal = Neurobiology of Disease | volume = 14 | issue = 1 | pages = 63–73 | date = Oct 2003 | pmid = 13678667 | doi = 10.1016/S0969-9961(03)00101-3 | s2cid = 21159141 }} {{refend}}

Category:EC 1.1.1

AKR1C1

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