{{short description|Family of aldo-keto reductase enzymes}} [[File:Protein AKR1C1 PDB 1ihi.png|thumb|right|300px|class=bg-transparent|AKR1C1, a member of the AKR1 family.]]
'''Aldo-keto reductase family 1''' ('''AKR1''') is a family of aldo-keto reductase enzymes that is involved in steroid metabolism.<ref name="pmid24189185">{{cite journal | vauthors = Rižner TL, Penning TM | title = Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism | journal = Steroids | volume = 79 | pages = 49–63 | year = 2014 | pmid = 24189185 | pmc = 3870468 | doi = 10.1016/j.steroids.2013.10.012 }}</ref> It includes the AKR1C and AKR1D subgroups, which respectively consist of AKR1C1–AKR1C4 and AKR1D1.<ref name="pmid24189185" /> Together with short-chain dehydrogenase/reductases (SDRs), these enzymes catalyze oxidoreductions, act on the C3, C5, C11, C17 and C20 positions of steroids, and function as {{abbrlink|3α-HSD|3α-Hydroxysteroid dehydrogenases}}, {{abbrlink|3β-HSDs|3β-Hydroxysteroid dehydrogenases}}, 5β-reductases, {{abbrlink|11β-HSDs|11β-Hydroxysteroid dehydrogenases}}, {{abbrlink|17β-HSDs|17β-hydroxysteroid dehydrogenases}}, and {{abbrlink|20α-HSDs|20α-Hydroxysteroid dehydrogenases}}, respectively.<ref name="pmid24189185" /> The AKR1C enzymes act as 3-, 17- and 20-ketosteroid reductases, while AKR1D1 acts as the sole 5β-reductase in humans.<ref name="pmid24189185" />
==Members== AKR1A1; AKR1B1; AKR1B10; AKR1C1; AKR1C2; AKR1C3; AKR1C4; AKR1D1; Others
==See also== * Steroidogenic enzyme
==References== {{Reflist|2}}
{{Alcohol oxidoreductases}} {{Enzymes}} {{Portal bar|Biology|border=no}}
Category:Enzymes
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