AKAP1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''A kinase anchor protein 1, mitochondrial''' is an enzyme that in humans is encoded by the ''AKAP1'' gene.<ref name="pmid8769136">{{cite journal |vauthors=Trendelenburg G, Hummel M, Riecken EO, Hanski C | title = Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain | journal = Biochem Biophys Res Commun | volume = 225 | issue = 1 | pages = 313–9 |date=Sep 1996 | pmid = 8769136 | doi = 10.1006/bbrc.1996.1172 }}</ref><ref name="pmid7499250">{{cite journal |vauthors=Lin RY, Moss SB, Rubin CS | title = Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells | journal = J Biol Chem | volume = 270 | issue = 46 | pages = 27804–11 |date=Jan 1996 | pmid = 7499250 | doi =10.1074/jbc.270.46.27804 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AKAP1 A kinase (PRKA) anchor protein 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8165}}</ref>

== Function ==

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.<ref name="entrez" />

== Interactions ==

AKAP1 has been shown to interact with: {{div col|colwidth=20em}} * C3orf15,<ref name = pmid12223483/> * MYCBP,<ref name = pmid12223483>{{cite journal | date = Nov 2002 |vauthors=Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H | title = AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase | journal = J. Biol. Chem. | volume = 277 | issue = 47 | pages = 45480–92 | pmid = 12223483 | doi = 10.1074/jbc.M206201200| doi-access = free }}</ref><ref name = pmid11483602>{{cite journal | date = Sep 2001 |vauthors=Furusawa M, Ohnishi T, Taira T, Iguchi-Ariga SM, Ariga H | title = AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase | journal = J. Biol. Chem. | volume = 276 | issue = 39 | pages = 36647–51 | pmid = 11483602 | doi = 10.1074/jbc.M103885200| doi-access = free }}</ref> * PRKAR1A,<ref name = pmid12634056>{{cite journal | date = Mar 2003 |vauthors=Carlson CR, Ruppelt A, Taskén K | title = A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system | journal = J. Mol. Biol. | volume = 327 | issue = 3 | pages = 609–18 | pmid = 12634056 | doi = 10.1016/S0022-2836(03)00093-7}}</ref><ref name = pmid10764601>{{cite journal | date = April 2000 | vauthors = Herberg FW, Maleszka A, Eide T, Vossebein L, Tasken K | title = Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding | journal = J. Mol. Biol. | volume = 298 | issue = 2 | pages = 329–39 | pmid = 10764601 | doi = 10.1006/jmbi.2000.3662}}</ref> * PRKAR1B,<ref name = pmid12634056/> and * PRKAR2A.<ref name = pmid10764601/><ref name = pmid10413680>{{cite journal | date = Aug 1999 |vauthors=Kapiloff MS, Schillace RV, Westphal AM, Scott JD | title = mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes | journal = J. Cell Sci. | volume = 112 | issue = 16| pages = 2725–36 |doi=10.1242/jcs.112.16.2725 | pmid = 10413680 }}</ref> {{Div col end}}

==References== {{Reflist}}

==External links== * {{UCSC gene info|AKAP1}}

==Further reading== {{Refbegin | 2}} *{{cite journal |vauthors=Lester LB, Scott JD |title=Anchoring and scaffold proteins for kinases and phosphatases |journal=Recent Prog. Horm. Res. |volume=52 |pages= 409–29; discussion 429–30 |year= 1997 |pmid= 9238861 }} *{{cite journal |vauthors=Michel JJ, Scott JD |title=AKAP mediated signal transduction |journal=Annu. Rev. Pharmacol. Toxicol. |volume=42 |pages= 235–57 |year= 2002 |pmid= 11807172 |doi= 10.1146/annurev.pharmtox.42.083101.135801 }} *{{cite journal |vauthors=Huang LJ, Durick K, Weiner JA |title=Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits |journal=J. Biol. Chem. |volume=272 |issue= 12 |pages= 8057–64 |year= 1997 |pmid= 9065479 |doi=10.1074/jbc.272.12.8057 |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Huang LJ, Wang L, Ma Y |title=NH2-Terminal Targeting Motifs Direct Dual Specificity A-Kinase–anchoring Protein 1 (D-AKAP1) to Either Mitochondria or Endoplasmic Reticulum |journal=J. Cell Biol. |volume=145 |issue= 5 |pages= 951–9 |year= 1999 |pmid= 10352013 |doi=10.1083/jcb.145.5.951 | pmc=2133123 |display-authors=etal}} *{{cite journal |vauthors=Herberg FW, Maleszka A, Eide T |title=Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding |journal=J. Mol. Biol. |volume=298 |issue= 2 |pages= 329–39 |year= 2000 |pmid= 10764601 |doi= 10.1006/jmbi.2000.3662 |display-authors=etal}} *{{cite journal |vauthors=Steen RL, Martins SB, Taskén K, Collas P |title=Recruitment of Protein Phosphatase 1 to the Nuclear Envelope by a-Kinase Anchoring Protein Akap149 Is a Prerequisite for Nuclear Lamina Assembly |journal=J. Cell Biol. |volume=150 |issue= 6 |pages= 1251–62 |year= 2000 |pmid= 10995432 |doi=10.1083/jcb.150.6.1251 | pmc=2150688 }} *{{cite journal |vauthors=Furusawa M, Ohnishi T, Taira T |title=AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36647–51 |year= 2001 |pmid= 11483602 |doi= 10.1074/jbc.M103885200 |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Razani B, Lisanti MP |title=Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A |journal=Am. J. Physiol., Cell Physiol. |volume=281 |issue= 4 |pages= C1241–50 |year= 2001 |pmid= 11546661 |doi= 10.1152/ajpcell.2001.281.4.C1241|s2cid=34190425 }} *{{cite journal |vauthors=Yukitake H, Furusawa M, Taira T |title=AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45480–92 |year= 2003 |pmid= 12223483 |doi= 10.1074/jbc.M206201200 |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H |title=AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50885–92 |year= 2003 |pmid= 12414807 |doi= 10.1074/jbc.M206387200 |doi-access= free }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Carlson CR, Ruppelt A, Taskén K |title=A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system |journal=J. Mol. Biol. |volume=327 |issue= 3 |pages= 609–18 |year= 2003 |pmid= 12634056 |doi=10.1016/S0022-2836(03)00093-7 }} *{{cite journal |vauthors=Steen RL, Beullens M, Landsverk HB |title=AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase |journal=J. Cell Sci. |volume=116 |issue= Pt 11 |pages= 2237–46 |year= 2004 |pmid= 12697839 |doi= 10.1242/jcs.00432 |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 | pmc=395752 |doi-access=free }} *{{cite journal |vauthors=Cardone L, Carlucci A, Affaitati A |title=Mitochondrial AKAP121 Binds and Targets Protein Tyrosine Phosphatase D1, a Novel Positive Regulator of src Signaling |journal=Mol. Cell. Biol. |volume=24 |issue= 11 |pages= 4613–26 |year= 2004 |pmid= 15143158 |doi= 10.1128/MCB.24.11.4613-4626.2004 | pmc=416429 |display-authors=etal}} *{{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |display-authors=etal|doi-access=free }} {{Refend}}

Category:A-kinase-anchoring proteins