Zonadhesin

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}}

'''Zonadhesin''' is a protein that in humans is encoded by the ZAN gene. <ref name="entrez"> {{cite web | title = Entrez Gene: Zonadhesin (gene/pseudogene) | url = https://www.ncbi.nlm.nih.gov/gene/7455 | access-date = 2018-06-28 }}</ref>

==Function==

This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition.

An allelic polymorphism in this gene results in both functional and frameshifted alleles; the reference genome represents the functional allele. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015].

== References ==

== Further reading ==

{{refbegin | 2}} *{{cite journal |vauthors=Gasper J, Swanson WJ |title=Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution |journal=Am. J. Hum. Genet. |volume=79 |issue=5 |pages=820–30 |date=November 2006 |pmid=17033959 |pmc=1698559 |doi=10.1086/508473 }} *{{cite journal |vauthors=Gnanasekar M, Suleman FG, Ramaswamy K, Caldwell JD |title=Identification of sex hormone binding globulin-interacting proteins in the brain using phage display screening |journal=Int. J. Mol. Med. |volume=24 |issue=4 |pages=421–6 |date=October 2009 |pmid=19724880 |doi= 10.3892/ijmm_00000248|doi-access=free }} *{{cite journal |vauthors=Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD |title=Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip |journal=Am. J. Hum. Genet. |volume=85 |issue=5 |pages=628–42 |date=November 2009 |pmid=19913121 |pmc=2775832 |doi=10.1016/j.ajhg.2009.10.014 }}