{{Chembox |ImageFile = Vernolepin.svg |ImageSize = 160px |PIN = (3a''R'',4''S'',5a''R'',9a''R'',9b''R'')-5a-Ethenyl-4-hydroxy-3,9-dimethylideneoctahydro-2''H''-furo[2,3-''f''][2]benzopyran-2,8(3''H'')-dione |OtherNames = Vernolepin |Section1={{Chembox Identifiers |CASNo = 18542-37-5 |CASNo_Ref = {{cascite|correct|CAS}} |UNII_Ref = {{fdacite|correct|FDA}} |UNII = 6640X1BVDX |PubChem = 442322 |ChemSpiderID = 390780 |SMILES = C=C[C@]12C[C@@H]([C@@H]3[C@@H]([C@H]1C(=C)C(=O)OC2)OC(=O)C3=C)O |InChI = 1/C15H16O5/c1-4-15-5-9(16)10-7(2)14(18)20-12(10)11(15)8(3)13(17)19-6-15/h4,9-12,16H,1-3,5-6H2/t9-,10+,11+,12-,15+/m0/s1 |InChIKey = IFYQXAXVZGMFNW-MVIRXUPPBC |StdInChI = 1S/C15H16O5/c1-4-15-5-9(16)10-7(2)14(18)20-12(10)11(15)8(3)13(17)19-6-15/h4,9-12,16H,1-3,5-6H2/t9-,10+,11+,12-,15+/m0/s1 |StdInChIKey = IFYQXAXVZGMFNW-MVIRXUPPSA-N |KEGG = C09582}} |Section2={{Chembox Properties |Formula=C<sub>15</sub>H<sub>16</sub>O<sub>5</sub> |MeltingPtC = 179 to 180 |MeltingPt_ref =<ref>{{cite journal|last=Laekeman|first=G. M.|author2=Mertens, J. |author3=Totté, J. |author4=Bult, H. |author5=Vlietinck, A. J. |author6= Herman, A. G. |title=Isolation and Pharmacological Characterization of Vernolepin|journal=Journal of Natural Products|date=1 March 1983|volume=46|issue=2|pages=161–169|doi=10.1021/np50026a003|pmid=6410002 |bibcode=1983JNAtP..46..161L }}</ref> }} }}
'''Vernolepin''' is a sesquiterpene lactone isolated from the dried fruit of ''Vernonia amygdalina''. It shows platelet anti-aggregating properties<ref>{{cite journal|last=Laekeman|first=G. M.|author2=Clerck, F. |author3=Vlietinck, A. J. |author4= Herman, A. G. |title=Vernolepin: An antiplatelet compound of natural origin|journal=Naunyn-Schmiedeberg's Archives of Pharmacology|date=1 January 1985|volume=331|issue=1|pages=108–113|doi=10.1007/BF00498859|pmid=3934564|s2cid=10373287}}</ref> and is also an irreversible DNA polymerase inhibitor,<ref>{{cite book|last=Clayden|first=Jonathan|title=Organic chemistry|year=2005|publisher=Oxford Univ. Press|location=Oxford [u.a.]|isbn=978-0-19-850346-0|pages=[https://archive.org/details/organicchemistry00clay_0/page/238 238]|edition=Reprinted (with corrections).|url-access=registration|url=https://archive.org/details/organicchemistry00clay_0/page/238}}</ref> hence may have antitumor properties.
==References== {{Reflist}}
Category:Sesquiterpene lactones Category:Secondary alcohols Category:Alkene derivatives Category:DNA polymerase inhibitors
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