[[File:Vacuolar interface dermatitis, annotated.jpg|thumb|Vacuolar interface dermatitis, with lymphocytes in the dermis and epidermis (black arrow indicates one), and vacuolization (white arrow) at the dermoepidermal junction.]] [[Image:Vacuolar interface dermatitis - high mag.jpg|thumb|right|Micrograph of a vacuolar interface dermatitis with dermal mucin, as may be seen in lupus. H&E stain.]] '''Vacuolar interface dermatitis''' ('''VAC''', also known as '''liquefaction degeneration''', '''vacuolar alteration''' or '''hydropic degeneration''') is a dermatitis with vacuolization at the dermoepidermal junction, with lymphocytic inflammation at the epidermis and dermis.<ref name="bolognia">{{cite book |author=Bolognia, Jean L.|title=Dermatology |publisher=Mosby |location=St. Louis |year=2007 |pages=11 |isbn=1-4160-2999-0 |display-authors=etal}}</ref>
==Causes== {{Table of causes of vacuolar interface dermatitis}} An interface dermatitis with vacuolar alteration, not otherwise specified, may be caused by viral exanthems, phototoxic dermatitis, acute radiation dermatitis, erythema dyschromicum perstans, lupus erythematosus and dermatomyositis.<ref name="Alsaad2005unless"/>
==References== {{reflist}}
Category:Dermatologic terminology