[[File:Oxypertine.svg|thumb|right|200px|class=skin-invert-image|Oxypertine, the most well-known drug of the pertine group.]]

The '''pertines''', also known as '''phenylpiperazinylethylindoles''', are a group of antipsychotics of the cyclized tryptamine and phenylpiperazine families that includes the following drugs:<ref name="Elks2014">{{cite book | last=Elks | first=J. | title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies | publisher=Springer | date=14 November 2014 | isbn=978-1-4757-2085-3 | url=https://books.google.com/books?id=0vXTBwAAQBAJ | access-date=18 June 2025 | page=}}</ref><ref name="MegensKennis1996">{{cite journal | vauthors = Megens AA, Kennis LE | title = Risperidone and related 5HT2/D2 antagonists: a new type of antipsychotic agent? | journal = Prog Med Chem | series = Progress in Medicinal Chemistry | volume = 33 | issue = | pages = 185–232 | date = 1996 | pmid = 8776944 | doi = 10.1016/s0079-6468(08)70306-0 | isbn = 978-0-444-82310-6 | url = }}</ref>

* Alpertine (WIN-31665) * Milipertine (WIN-18935) * Oxypertine (WIN-18501) * Solypertine (WIN-18413)

Oxypertine is known to show high affinity for the serotonin 5-HT<sub>2</sub> and dopamine D<sub>2</sub> receptors (K<sub>i</sub> = 8.6{{nbsp}}nM and 30{{nbsp}}nM, respectively) and to also act as a catecholamine depleting agent.<ref name="MegensKennis1996" /><ref name="BakHasslerKim1969">{{cite journal | vauthors = Bak IJ, Hassler R, Kim JS | title = Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin | journal = Zeitschrift für Zellforschung und Mikroskopische Anatomie | volume = 101 | issue = 3 | pages = 448–462 | year = 1969 | pmid = 5362847 | doi = 10.1007/BF00335580 | s2cid = 32583722 }}</ref> Oxypertine, milipertine, and solypertine all antagonize the behavioral effects of tryptamine, a serotonin receptor agonist, and apomorphine, a dopamine receptor agonist, in animals.<ref name="MegensKennis1996" /><ref name="NiemegeersJanssen1979">{{cite journal | vauthors = Niemegeers CJ, Janssen PA | title = A systematic study of the pharmacological activities of dopamine antagonists | journal = Life Sciences | volume = 24 | issue = 24 | pages = 2201–2216 | date = June 1979 | pmid = 388130 | doi = 10.1016/0024-3205(79)90096-1 | publisher = Elsevier BV }}</ref>

Some of the pertines, like milipertine and solypertine, are notable in containing an NBOMe-like moiety.<ref name="Elks2014" /><ref name="MegensKennis1996" />

The pertines were developed and initially described in the 1960s and 1970s.<ref name="Elks2014" />

{{Gallery | title = Chemical structures of pertines | height = 145 | width = 145 | File:Alpertine.svg | class1=skin-invert-image | Alpertine | File:Milipertine.svg | class2=skin-invert-image | Milipertine | File:Oxypertine.svg | class3=skin-invert-image | Oxypertine | File:Solypertine.svg | class4=skin-invert-image | Solypertine }}

==See also== * Cyclized tryptamine * 5-MeO-T-NBOMe * ''N''-Benzyltryptamine * Carmoxirole * B-193

==References== {{Reflist}}

{{Antipsychotics}} {{Tryptamines}} {{Arylpiperazines}}

Category:Pertines

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