{{cs1 config|name-list-style=vanc}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Periplakin''' is a protein that in humans is encoded by the ''PPL'' gene.<ref name="pmid9570964">{{cite journal |vauthors=Ruhrberg C, Williamson JA, Maatta A, Watt FM | title = The periplakin gene maps to 16p13.3 in human and 16A-B1 in mouse | journal = Genomics | volume = 49 | issue = 1 | pages = 157–9 |date=Jun 1998 | pmid = 9570964 | doi = 10.1006/geno.1997.5206 }}</ref><ref name="pmid9521878">{{cite journal |vauthors=Aho S, McLean WH, Li K, Uitto J | title = cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes | journal = Genomics | volume = 48 | issue = 2 | pages = 242–7 |date=Jun 1998 | pmid = 9521878 | doi = 10.1006/geno.1997.5188 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPL periplakin| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5493}}</ref>
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.<ref name="entrez"/>
==Interactions== PPL (gene) has been shown to interact with Keratin 8<ref name=pmid12366696>{{cite journal |last=Kazerounian |first=Shideh |author2=Uitto Jouni |author3=Aho Sirpa |date=Oct 2002 |title=Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin |journal=Exp. Dermatol. |volume=11 |issue=5 |pages=428–38 |location = Denmark| issn = 0906-6705| pmid = 12366696 |doi=10.1034/j.1600-0625.2002.110506.x |s2cid=25735126 }}</ref> and Envoplakin.<ref name=pmid12432088>{{cite journal |last=Karashima |first=Tadashi |author2=Watt Fiona M |date=Dec 2002 |title=Interaction of periplakin and envoplakin with intermediate filaments |journal=J. Cell Sci. |volume=115 |issue=Pt 24 |pages=5027–37 |location = England| issn = 0021-9533| pmid = 12432088 |doi=10.1242/jcs.00191 |s2cid=22383123 |doi-access= }}</ref><ref name=pmid9412476>{{cite journal |last=Ruhrberg |first=C |author2=Hajibagheri M A |author3=Parry D A |author4=Watt F M |date=Dec 1997 |title=Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin |journal=J. Cell Biol. |volume=139 |issue=7 |pages=1835–49 |location = UNITED STATES| issn = 0021-9525| pmid = 9412476 |doi=10.1083/jcb.139.7.1835 |pmc=2132639 }}</ref>
== See also == * List of target antigens in pemphigus
==References== {{reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal | author=Amagai M |title=Autoimmunity against desmosomal cadherins in pemphigus. |journal=J. Dermatol. Sci. |volume=20 |issue= 2 |pages= 92–102 |year= 1999 |pmid= 10379702 |doi=10.1016/S0923-1811(99)00016-X }} *{{cite journal |vauthors=Leung CL, Green KJ, Liem RK |title=Plakins: a family of versatile cytolinker proteins. |journal=Trends Cell Biol. |volume=12 |issue= 1 |pages= 37–45 |year= 2002 |pmid= 11854008 |doi=10.1016/S0962-8924(01)02180-8 }} *{{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }} *{{cite journal |vauthors=Ruhrberg C, Hajibagheri MA, Parry DA, Watt FM |title=Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin. |journal=J. Cell Biol. |volume=139 |issue= 7 |pages= 1835–49 |year= 1998 |pmid= 9412476 |doi=10.1083/jcb.139.7.1835 | pmc=2132639 }} *{{cite journal |vauthors=Nagase T, Ishikawa K, Miyajima N, etal |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=10.1093/dnares/5.1.31 |doi-access=free }} *{{cite journal |vauthors=Aho S, Rothenberger K, Tan EM, etal |title=Human periplakin: genomic organization in a clonally unstable region of chromosome 16p with an abundance of repetitive sequence elements. |journal=Genomics |volume=56 |issue= 2 |pages= 160–8 |year= 1999 |pmid= 10051401 |doi= 10.1006/geno.1998.5704 }} *{{cite journal |vauthors=DiColandrea T, Karashima T, Määttä A, Watt FM |title=Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope. |journal=J. Cell Biol. |volume=151 |issue= 3 |pages= 573–86 |year= 2000 |pmid= 11062259 |doi=10.1083/jcb.151.3.573 | pmc=2185584 }} *{{cite journal |vauthors=van den Heuvel AP, de Vries-Smits AM, van Weeren PC, etal |title=Binding of protein kinase B to the plakin family member periplakin. |journal=J. Cell Sci. |volume=115 |issue= Pt 20 |pages= 3957–66 |year= 2003 |pmid= 12244133 |doi=10.1242/jcs.00069 |s2cid=12136252 |doi-access= }} *{{cite journal |vauthors=Kazerounian S, Uitto J, Aho S |title=Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin. |journal=Exp. Dermatol. |volume=11 |issue= 5 |pages= 428–38 |year= 2003 |pmid= 12366696 |doi=10.1034/j.1600-0625.2002.110506.x |s2cid=25735126 }} *{{cite journal |vauthors=Karashima T, Watt FM |title=Interaction of periplakin and envoplakin with intermediate filaments. |journal=J. Cell Sci. |volume=115 |issue= Pt 24 |pages= 5027–37 |year= 2003 |pmid= 12432088 |doi=10.1242/jcs.00191 |s2cid=22383123 |doi-access= }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Feng GJ, Kellett E, Scorer CA, etal |title=Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation. |journal=J. Biol. Chem. |volume=278 |issue= 35 |pages= 33400–7 |year= 2003 |pmid= 12810704 |doi= 10.1074/jbc.M305866200 |doi-access= free}} *{{cite journal |vauthors=Kazerounian S, Aho S |title=Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36707–17 |year= 2003 |pmid= 12853457 |doi= 10.1074/jbc.M303896200 |doi-access= free }} *{{cite journal |vauthors=Straub BK, Boda J, Kuhn C, etal |title=A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells. |journal=J. Cell Sci. |volume=116 |issue= Pt 24 |pages= 4985–95 |year= 2004 |pmid= 14625392 |doi= 10.1242/jcs.00815 |doi-access= free }} *{{cite journal |vauthors=Kalinin AE, Idler WW, Marekov LN, etal |title=Co-assembly of envoplakin and periplakin into oligomers and Ca(2+)-dependent vesicle binding: implications for cornified cell envelope formation in stratified squamous epithelia. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22773–80 |year= 2004 |pmid= 15033990 |doi= 10.1074/jbc.M313660200 |doi-access= free}} *{{cite journal |vauthors=Beekman JM, Bakema JE, van de Winkel JG, Leusen JH |title=Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 28 |pages= 10392–7 |year= 2004 |pmid= 15229321 |doi= 10.1073/pnas.0401217101 | pmc=478582 |bibcode=2004PNAS..10110392B |doi-access=free }} {{refend}}
== External links == * {{PDBe-KB2|O60437|Periplakin}}
Category:Plakins
{{gene-16-stub}}