{{Short description|Mammalian protein found in Homo sapiens}} {{infobox protein |Name='''Phosphoinositide-3-kinase adapter protein of 87 kDa''' |caption= |image= |width= |HGNCid=27101 |Symbol=p87<sup>PIKAP</sup> |AltSymbols=p84,PIK3R6 |EntrezGene=146850 |UniProt=Q5UE93 |OMIM=611462 |PDB= |ECnumber= |Chromosome=17 |Arm=p |Band=13.1 |LocusSupplementaryData= }} Within molecular and cell biology, '''p87<sup>PIKAP</sup>''' is a regulatory subunit of the type IB Phosphoinositide 3-Kinase p110γ that is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils.<ref name="pmid16476736">{{cite journal | vauthors = Voigt P, Dorner MB, Schaefer M | title = Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B | journal = The Journal of Biological Chemistry | volume = 281 | issue = 15 | pages = 9977–86 | year = 2006 | pmid = 16476736 | doi = 10.1074/jbc.M512502200 | doi-access = free }}</ref> It is also referred to as p84 and p87.<ref name="pmid19906996">{{cite journal | vauthors = Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, Schaefer M, Gohla A, Harteneck C, Wymann MP, Jeanclos E, Nürnberg B | display-authors = 6 | title = Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 48 | pages = 20312–7 | year = 2009 | pmid = 19906996 | pmc = 2787109 | doi = 10.1073/pnas.0905506106 | bibcode = 2009PNAS..10620312K | doi-access = free }}</ref> Some studies have found P87PIKAP to have a role in carcinogenesis.<ref>{{cite journal|title=Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis|url=https://www.nature.com/onc/journal/v31/n18/pdf/onc2011414a.pdf?origin=ppub|first1=JA |last1=Brazzatti|display-authors=etal|journal=Oncogene|date=2012|volume=31|issue = 18|pages=2350–2361|doi=10.1038/onc.2011.414|pmid = 21996737|s2cid = 24708435|doi-access=free}}</ref>
== References == {{reflist}}
thumb|300px|The context of the function of p87.
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