{{Infobox medical condition (new) | name = Nodular sclerosing Hodgkin lymphoma | synonyms = Nodular sclerosis | image = Hodgkin's disease, nodular sclerosis.jpg | caption = The distinct nodules on the cut surface of this lymph node strongly suggest the diagnosis of nodular sclerosis. | pronounce = | field = | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }} '''Nodular sclerosing Hodgkin lymphoma''' ("NSHL") or '''Nodular sclerosis''' is a form of Hodgkin lymphoma<ref name="pmid17908180">{{cite journal |vauthors=Falchi L, Capello D, Palumbo B, etal |title=A case of nodular sclerosis Hodgkin's lymphoma repeatedly relapsing in the context of composite plasma cell-hyaline vascular Castleman's disease: successful response to rituximab and radiotherapy |journal=Eur. J. Haematol. |volume=79 |issue=5 |pages=455–61 |date=November 2007 |pmid=17908180 |pmc=2121125 |doi=10.1111/j.1600-0609.2007.00952.x}}</ref> that is the most common subtype of HL in developed countries. It affects females slightly more than males and has a median age of onset at ~28 years. It is composed of large tumor nodules with lacunar Reed–Sternberg cell (RS cells) surrounded by fibrotic collagen bands.<ref>{{Cite web |title=Lacunar Cells in Classical Hodgkin Lymphoma |url=https://imagebank.hematology.org/image/61476/lacunar-cells-in-classical-hodgkin-lymphoma |access-date=2026-01-07 |website=imagebank.hematology.org}}</ref>
The British National Lymphoma Investigation further categorized NSHL based upon Reed–Sternberg cells into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first subtype responding better to treatment.<ref> {{cite book | last=Mauch | first=Peter |author2=James Armitage |author3=Volker Diehl |author4=Richard Hoppe |author5=Laurence Weiss | title=Hodgkin's Disease | publisher=Lippincott Williams & Wilkins | date=1999 | isbn=978-0-7817-1502-7 | page=107}} </ref>
==References== {{reflist}}
== External links == * [https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11712426&dopt=Abstract PubMed] – use of Erythropoietin * [https://www.ncbi.nlm.nih.gov/books/NBK20849/ Subtypes] * [http://www.lymphomas.org.uk/userfiles/file/pdf/Types%20of%20lymphoma/hodgkin%20lymphoma/Hodgkin%20lymphoma%20booklet.pdf Lymphoma Association information on nodular sclerosing] {{Webarchive|url=https://web.archive.org/web/20090320110010/http://www.lymphomas.org.uk/userfiles/file/pdf/Types%20of%20lymphoma/hodgkin%20lymphoma/Hodgkin%20lymphoma%20booklet.pdf |date=2009-03-20 }} {{Medical resources | DiseasesDB = | ICD10 = {{ICD10|C|81|1|c|81}} | ICD9 = {{ICD9|201.5}} | ICDO = {{ICDO|9663|3}}-9667/3 | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = }}
{{Lymphoid malignancy}}
Category:Histopathology Category:Hodgkin lymphoma
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