{{Chembox | ImageFile = Nitarsone.svg | ImageClass = skin-invert-image | ImageSize = 200px | PIN = (4-Nitrophenyl)arsonic acid | OtherNames = (''p''-Nitrophenyl)arsonic acid; 4-Nitrobenzenearsonic acid |Section1={{Chembox Identifiers | CASNo = 98-72-6 | CASNo_Ref = {{cascite|correct|CAS}} | UNII_Ref = {{fdacite|correct|FDA}} | UNII = JP2EN8WORU | PubChem = 66826 | ChemSpiderID = 60190 | SMILES = O=[N+]([O-])c1ccc(cc1)[As](=O)(O)O | InChI = 1/C6H6AsNO5/c9-7(10,11)5-1-3-6(4-2-5)8(12)13/h1-4H,(H2,9,10,11) | InChIKey = FUUFQLXAIUOWML-UHFFFAOYAA | StdInChI = 1S/C6H6AsNO5/c9-7(10,11)5-1-3-6(4-2-5)8(12)13/h1-4H,(H2,9,10,11) | StdInChIKey = FUUFQLXAIUOWML-UHFFFAOYSA-N }} |Section2={{Chembox Properties | C=6 | H=6 | As=1 | N=1 | O=5 | Appearance = | Density = | MeltingPtC = 298-300 | MeltingPt_notes = (decomposes) | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }} '''Nitarsone''' is an organoarsenic compound that is used in poultry production as a feed additive to increase weight gain, improve feed efficiency, and prevent histomoniasis (blackhead disease).<ref>{{cite news | author = U.S. Food and Drug Administration | url = http://www.accessdata.fda.gov/scripts/animaldrugsatfda | title = Animal Drugs @ FDA}}{{dead link|date=May 2025|bot=medic}}{{cbignore|bot=medic}}</ref> It is marketed as '''Histostat''' by Zoetis.<ref>{{cite news | author = Zoetis | url = https://online.zoetis.com/US/EN/Products/Pages/Histostat.aspx | title = Histostat: Type A Medicated Feed Article | archive-date = 2013-09-19 | access-date = 2013-05-11 | archive-url = https://web.archive.org/web/20130919225352/https://online.zoetis.com/US/EN/Products/Pages/Histostat.aspx | url-status = dead }}</ref>
Nitarsone once was one of four arsenical food-animal drugs—along with roxarsone, arsanilic acid, and carbarsone—approved by the U.S. Food and Drug Administration for use in feeding poultry.<ref name=FDAQ&A>{{cite news | author = U.S. Food and Drug Administration | url = https://www.fda.gov/AnimalVeterinary/SafetyHealth/ProductSafetyInformation/ucm258313.htm | archive-url = https://web.archive.org/web/20110612145259/http://www.fda.gov/AnimalVeterinary/SafetyHealth/ProductSafetyInformation/ucm258313.htm | url-status = dead | archive-date = June 12, 2011 | title = Questions and Answers Regarding 3-Nitro (Roxarsone) | date = June 8, 2011}}</ref> However, following the suspension of sales of roxarsone in the United States in 2011, nitarsone was thought to be the only arsenical animal drug actually marketed in the U.S.<ref name=FDAQ&A /><ref>{{cite news | author = Sabrina Tavernise | url = https://www.nytimes.com/2013/05/11/health/study-finds-an-increase-in-arsenic-levels-in-chicken.html | title = Study Finds an Increase in Arsenic Levels in Chicken | work = New York Times | date = May 11, 2013}}</ref> In September 2013, the FDA announced that Zoetis and Fleming Laboratories agreed to voluntarily withdraw from using roxarsone, arsanilic acid, and carbarsone, which left nitarsone as the only arsenical approved in the U.S. for use in food animals.<ref>{{cite news | author = U.S. FDA | url = https://www.fda.gov/AnimalVeterinary/SafetyHealth/ProductSafetyInformation/ucm370568.htm | archive-url = https://web.archive.org/web/20131022074630/http://www.fda.gov/AnimalVeterinary/SafetyHealth/ProductSafetyInformation/ucm370568.htm | url-status = dead | archive-date = October 22, 2013 | title = FDA Response to Citizen Petition on Arsenic-based Animal Drugs | date = September 20, 2011}}</ref> But in 2015, the FDA also withdrew approval of nitarsone in animal feeds, effective at the end of 2015.<ref>{{cite news | author = U.S. Food and Drug Administration | url =https://www.fda.gov/AnimalVeterinary/NewsEvents/CVMUpdates/ucm440668.htm | archive-url =https://web.archive.org/web/20150404001249/http://www.fda.gov/AnimalVeterinary/NewsEvents/CVMUpdates/ucm440668.htm | url-status =dead | archive-date =April 4, 2015 | title =FDA Announces Pending Withdrawal of Approval of Nitarsone | date = April 1, 2015}}</ref>
==References== {{reflist}}
Category:Arsonic acids Category:Veterinary drugs Category:Antiprotozoal agents Category:Medicated feed