Methylamide

{{One source|date=November 2021}} In biochemistry, an '''''N''-methylamide''' (NME) is a blocking group for the C-terminus end of peptides. When the carboxyl group of the C-terminus is replaced with a methylamide, further elongation of the peptide chain is prevented. C-Terminal modified peptides are also useful for the modulation of structure-activity relationships and for modifying conformational properties of peptides. ''N''-Methylamides can be prepared directly from solid phase resin-bound peptides.<ref name="Ajayaghosh1996">{{cite journal |author1=Ajayaghosh, A. |author2=Pillai, V. N. Rajasekharan | title = Photo-triggered selective C-terminal N-methylamidative cleavage of polyethylene glycol-bound peptides | journal = Tetrahedron Letters | year = 1996 | volume = 37 | issue = 35 | pages = 6421–6424 | doi = 10.1016/0040-4039(96)01363-9}}</ref>

==References== {{reflist}}

Category:Carboxamides

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