{{Short description|Distribution of metal ions in a cellular compartment}} {{redirect|Metallomics|the journal|Metallomics (journal)}} In biochemistry, the '''metallome''' is the distribution of metal ions in a cellular compartment. The term was coined in analogy with proteome,<ref>{{harvnb|Williams|2001}}</ref> as '''metallomics''' is the study of metallome: the "comprehensive analysis of the entirety of metal and metalloid species within a cell or tissue type".<ref>{{harvnb|Szpunar|2005}}</ref> Therefore, metallomics can be considered a branch of metabolomics,{{citation needed|date=January 2018}} even though the metals are not typically considered as metabolites.
An alternative definition of "metallomes" as metalloproteins or any other metal-containing biomolecules, and "metallomics" is a study of such biomolecules.<ref>{{harvnb|Haraguchi|2004}}</ref>
==Metallointeractome== In the study of metallomes the transcriptome, proteome and the metabolome constitutes the whole metallome. A study of the metallome is done to arrive at the '''metallointeractome'''.
==Metallotranscriptome== The '''metallotranscriptome'''<ref name="Shanker2009">{{harvnb|Shanker|Djanaguiraman|Venkateswarlu|2009}}</ref> can be defined as the map of the entire transcriptome in the presence of biologically or environmentally relevant concentrations of an essential or toxic metal, respectively. The metallometabolome constitutes the complete pool of small metabolites in a cell at any given time. This gives rise to the whole metallointeractome and knowledge of this is important in comparative metallomics dealing with toxicity and drug discovery.<ref name="Shanker2009" />
==See also== * Bioinorganic chemistry * -omics
==References== {{Reflist}}
===Sources=== {{refbegin}} *{{cite book |last1=Banci |first1=Lucia |last2=Bertini |first2=Ivano |editor1-first=Lucia |editor1-last=Banci |series=Metal Ions in Life Sciences |volume=12 |pages=1–13 |chapter= Chapter 1. Metallomics and the Cell: Some Definitions and General Comments |title=Metallomics and the Cell |year=2013 |publisher=Springer |isbn=978-94-007-5560-4|doi=10.1007/978-94-007-5561-1_1 |pmid=23595668 }} electronic-book {{ISBN|978-94-007-5561-1}} {{issn|1559-0836}} electronic-{{issn|1868-0402}} * {{cite journal | last = Haraguchi | first = H. | title=Metallomics as integrated biometal science | journal=Journal of Analytical Atomic Spectrometry | date=2004 | volume=19 | pages=5–14 | doi=10.1039/b308213j }} * {{cite journal | last1 = Mounicou | first1 = S. | last2 = Szpunar | first2 = J. | last3 = Lobinski | first3 = R. | title=Metallomics: the concept and methodology | journal=Chemical Society Reviews | date=2009 | volume=38 | pages=1119–1138 | doi=10.1039/b713633c | pmid=19421584 | issue=4 }} *{{cite journal | last1=Shanker | first1 = A. K. | last2 = Djanaguiraman | first2 = M. | last3 = Venkateswarlu | first3 = B. | title=Chromium interactions in plants: current status and future strategiesw |journal=Metallomics | date = 2009 | volume=1 | pages=375–383 | doi=10.1039/b904571f | pmid = 21305140 | issue=5 | doi-access=free }} * {{cite journal | last = Szpunar | first = J. | title=Advances in analytical methodology for bioinorganic speciation analysis: metallomics, metalloproteomics and heteroatom-tagged proteomics and metabolomics | journal=The Analyst | date=2005 | volume=130 | pages=442–465 | pmid=15776152 | doi=10.1039/b418265k | issue=4 | bibcode = 2005Ana...130..442S }} * {{cite journal | last1 = Wackett | first1 = L. P. | last2 = Dodge | first2 = A. G. | last3 = Ellis | first3 = L. B. M. | title=Microbial genomics and the periodic table | journal=Applied and Environmental Microbiology | date=2004 | volume=70 | pages=647–655 | pmid=14766537 | doi=10.1128/AEM.70.2.647-655.2004 | issue=2 | pmc=348800 }} * {{cite journal | last = Williams | first = R.J.P. | title=Chemical selection of elements by cells | journal=Coordination Chemistry Reviews | date=2001 | volume=216–217 | pages=583–595 | doi = 10.1016/s0010-8545(00)00398-2 }} {{refend}}
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Category:Systems biology Category:Metabolism Category:Bioinformatics Category:Biochemistry methods