Membrane-spanning 4A

'''Membrane-spanning 4A''' genes are members of the CD20-like family. The MS4A genes are usually organized in a single genomic clusters in mammals, suggestive of gene duplication events.<ref name="pmid11486273">{{cite journal |vauthors=Liang Y, Buckley TR, Tu L, Langdon SD, Tedder TF |title=Structural organization of the human MS4A gene cluster on Chromosome 11q12 |journal=Immunogenetics |volume=53 |issue=5 |pages=357–68 |date=July 2001 |pmid=11486273 |doi= 10.1007/s002510100339|s2cid=21846867 }}</ref> MS4A genes encode a class of four-transmembrane spanning proteins. MS4A genes have been described to act as a specific kind of olfactory receptor in the necklace olfactory sensory neurons in mice (Mus musculus).<ref>Greer PL, Bear DM, Lassance JM, Bloom ML, Tsukahara T, Pashkovski SL, Masuda FK, Nowlan AC, Kirchner R, Hoekstra HE, et al. 2016. A family of non-GPCR chemosensors defines an alternative logic for mammalian olfaction. Cell. 165:1734–1748. [https://www.cell.com/cell/fulltext/S0092-8674(16)30549-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867416305499%3Fshowall%3Dtrue doi: 10.1016/j.cell.2016.05.001]. </ref>

In human (''Homo sapiens'') the members of this family include: * MS4A1 (better known as "CD20") * MS4A2 * MS4A3 * MS4A4A * MS4A4E * MS4A5 * MS4A6A * MS4A6E * MS4A7 * MS4A8 * MS4A9 * MS4A10 * MS4A12 * MS4A13 * MS4A14 * MS4A15 * MS4A18

== References == {{reflist}}

Category:Gene families