Lipoblast

{{short description|Precursor cell for an adipocyte (fat cell)}} thumb|Lipoblast features.

A '''lipoblast''' is a precursor cell for an adipocyte.<ref name="YoungWheater2006">{{cite book|author1=Barbara Young|author2=Paul R. Wheater|title=Wheater's functional histology: a text and colour atlas|url=https://books.google.com/books?id=88tla60sHAUC&pg=PA74|accessdate=18 April 2010|year=2006|publisher=Elsevier Health Sciences|isbn=978-0-443-06850-8|pages=74–}}</ref> Alternate terms include '''adipoblast'''<ref name="pmid10592389">{{cite journal |author=Dani C |title=Embryonic stem cell-derived adipogenesis |journal=Cells Tissues Organs (Print) |volume=165 |issue=3–4 |pages=173–80 |year=1999 |pmid=10592389 |doi= 10.1159/000016697|s2cid=41201445 |url=http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=cto65173|url-access=subscription }}</ref> and '''preadipocyte'''.<ref name="pmid20385145">{{cite journal |vauthors=Coskun H, Summerfield TL, Kniss DA, Friedman A |title=Mathematical modeling of preadipocyte fate determination |journal=J Theor Biol |volume= 265|issue= 1|pages= 87–94|date=April 2010 |pmid=20385145 |doi=10.1016/j.jtbi.2010.03.047 |bibcode=2010JThBi.265...87C }}</ref> Early stages are almost indistinguishable from fibroblasts.<ref name="HenriksonKaye1997">{{cite book|author1=Ray C. Henrikson|author2=Gordon I. Kaye|author3=Joseph E. Mazurkiewicz|title=Histology|url=https://books.google.com/books?id=2i_ToCBIt8UC&pg=PA118|accessdate=18 April 2010|date=31 July 1997|publisher=Lippincott Williams & Wilkins|isbn=978-0-683-06225-0|pages=118–}}</ref>

<gallery> File:Lipoblasts and lipocytes.jpg|Lipoblasts (white arrow) and lipocytes (black arrow), in a case of lipoblastoma File:Dedifferentiated liposarcoma - cropped - very high mag.jpg|Micrograph showing a lipoblast (left-bottom of image) in a liposarcoma. H&E stain. File:Histopathology of liposarcoma, annotated.jpg|Histopathology of liposarcoma, H&E stain, with the main features:<ref name=PathologyOutlines>{{cite web|url=https://www.pathologyoutlines.com/topic/softtissuewdliposarcoma.html%7Ctitle=Liposarcoma|author=Michael R. Clay, M.D.|website=PathologyOutlines|title=Liposarcoma}} Topic Completed: 1 November 2017. Minor changes: 11 May 2021</ref><br>- Spindle cells with enlarged, hyperchromatic nuclei.<br>- Apparently univacuolated adipocytes (may look normal).<br>- '''Lipoblasts''' (multivacuolated), but neither necessary nor sufficient for diagnosis of liposarcoma. File:Histology of a lipoblast-like histiocyte in fat necrosis.jpg|Lipid-laden histiocytes may mimic lipoblasts, but have lightly eosinophilic cytoplasm and a small normochromatic nuclei which are not hollowed out from the lipid vacuoles.<ref>Image by Mikael Häggström, MD. Reference for findings: {{cite book | last=Gnepp | first=Douglas R. | title=Diagnostic Surgical Pathology of the Head and Neck | publisher=Saunders | publication-place=Philadelphia, PA | date=2009 | isbn=978-1-4160-2589-4}}</ref> </gallery>

==Liposarcoma== Lipoblasts are seen in liposarcoma<ref name="Layfield2002">{{cite book|author=Lester J. Layfield|title=Cytopathology of bone and soft tissue tumors|url=https://books.google.com/books?id=mNZixLqAIU4C&pg=PA83|accessdate=18 April 2010|year=2002|publisher=Oxford University Press US|isbn=978-0-19-513236-6|pages=83–}}</ref> and characteristically have abundant multivacuolated clear cytoplasm and a dark staining (hyperchromatic), indented nucleus.

*List of human cell types derived from the germ layers

== References == {{reflist|2}}

Category:Cell biology