{{More citations needed|date=October 2021}} {{Infobox medical condition (new) | name = Large-cell lymphoma | synonyms = | image = Primary mediastinal large B-cell lymphoma - high mag.jpg | caption = Micrograph of a primary mediastinal large B-cell lymphoma, a type of large-cell lymphoma. H&E stain. | pronounce = | field = Oncology | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}

The '''large-cell lymphomas''' have large cells. One classification system for lymphomas divides the diseases according to the size of the white blood cells that have turned cancerous. A large cell, in this context, has a diameter of 17 to 20&nbsp;μm.<ref name="isbn0-7817-5007-5">{{cite book |author=Turgeon, Mary Louise |title=Clinical hematology: theory and procedures |url=https://archive.org/details/clinicalhematolo0004turg |url-access=registration |publisher=Lippincott Williams & Wilkins |location=Hagerstown, MD |year=2005 |pages=[https://archive.org/details/clinicalhematolo0004turg/page/221 221] |isbn=0-7817-5007-5}}</ref> Other groups of lymphomas in this system are the small-cell lymphomas and mixed-cell lymphomas.

==Types==

===B cell=== Diffuse large B-cell lymphoma is the most common of the large-cell lymphomas. MeSH now classifies the phrase "large-cell lymphoma" under "Diffuse large B cell lymphoma".<ref>{{MeshName|Large+cell+lymphoma}}</ref>

Many other B-cell lymphomas feature large cells:{{cn|date=November 2021}} * Angiocentric lymphoma * Burkitt's lymphoma * Follicular large-cell lymphoma * Immunoblastic lymphoma * Intravascular large-cell lymphoma * Primary mediastinal B-cell lymphoma * T-cell–rich B-cell lymphoma * Primary splenic lymphoma (rare) * Primary central nervous system lymphomas, which are often diffuse large-B-cell lymphomas * Richter's transformation: Diffuse Large B-cell Variant *1) ABC subtype (common) *2) GCB subtype (rare)

Activated B-Cell Diffuse Large B-Cell Lymphoma, or ABC-DLBCL, is believed to be caused by aberrant activation of a critical intracellular pathway. This intracellular signaling pathway involved in B-cell activation and proliferation stays constantly activated, driving lymphocytes to proliferate continuously. The inhibition of this pathway can be induced by a drug known as NEMO Binding Domain, or NBD, a peptide causing increased cell death of malignant lymphocytes.{{citation needed|date=November 2018}}

===T cell=== Less commonly, a large-cell lymphoma may feature T cells. Anaplastic large-cell lymphoma is an example of a large-cell lymphoma that involves T cells. Of the large-cell T-cell lymphomas, it has the best prognosis.{{Citation needed|date=May 2010}}

==References== {{reflist}}

== External links == {{Medical resources | DiseasesDB = | ICD10 = | ICD9 = {{ICD9|200.7}} | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = D016403 }} {{Lymphoid malignancy}}

Category:Non-Hodgkin lymphoma