{{Short description|Specialty field of interventional radiology}} '''Interventional oncology''' (abbreviated '''IO''') is a subspecialty field of interventional radiology that deals with the diagnosis and treatment of cancer and cancer-related problems using targeted minimally invasive procedures performed under image guidance.<ref>{{Cite journal|doi = 10.1016/j.jvir.2013.04.023|title = Cancer Concepts and Principles: Primer for the Interventional Oncologist—Part II|year = 2013|last1 = Hickey|first1 = Ryan|last2 = Vouche|first2 = Michael|last3 = Sze|first3 = Daniel Y.|last4 = Hohlastos|first4 = Elias|last5 = Collins|first5 = Jeremy|last6 = Schirmang|first6 = Todd|last7 = Memon|first7 = Khairuddin|last8 = Ryu|first8 = Robert K.|last9 = Sato|first9 = Kent|last10 = Chen|first10 = Richard|last11 = Gupta|first11 = Ramona|last12 = Resnick|first12 = Scott|last13 = Carr|first13 = James|last14 = Chrisman|first14 = Howard B.|last15 = Nemcek|first15 = Albert A.|last16 = Vogelzang|first16 = Robert L.|last17 = Lewandowski|first17 = Robert J.|last18 = Salem|first18 = Riad|journal = Journal of Vascular and Interventional Radiology|volume = 24|issue = 8|pages = 1167–1188|pmid = 23810312|pmc = 3800031}}</ref><ref>{{Cite journal|doi = 10.1016/j.jvir.2013.04.024|title = Cancer Concepts and Principles: Primer for the Interventional Oncologist—Part I|year = 2013|last1 = Hickey|first1 = Ryan|last2 = Vouche|first2 = Michael|last3 = Sze|first3 = Daniel Y.|last4 = Hohlastos|first4 = Elias|last5 = Collins|first5 = Jeremy|last6 = Schirmang|first6 = Todd|last7 = Memon|first7 = Khairuddin|last8 = Ryu|first8 = Robert K.|last9 = Sato|first9 = Kent|last10 = Chen|first10 = Richard|last11 = Gupta|first11 = Ramona|last12 = Resnick|first12 = Scott|last13 = Carr|first13 = James|last14 = Chrisman|first14 = Howard B.|last15 = Nemcek|first15 = Albert A.|last16 = Vogelzang|first16 = Robert L.|last17 = Lewandowski|first17 = Robert J.|last18 = Salem|first18 = Riad|journal = Journal of Vascular and Interventional Radiology|volume = 24|issue = 8|pages = 1157–1164|pmid = 23809510|pmc = 3800037}}</ref> Interventional oncology has developed to a separate pillar of modern oncology and it employs X-ray, ultrasound, computed tomography (CT) or magnetic resonance imaging (MRI) to help guide miniaturized instruments (e.g. biopsy needles, ablation electrodes, intravascular catheters) to allow targeted and precise treatment of solid tumours (also known as neoplasms) located in various organs of the human body, including but not limited to the liver, kidneys, lungs, and bones.<ref name="sirweb">{{Cite web |url=http://www.sirweb.org/patients/liver-cancer/ |title=Interventional Radiology Treatments for Liver Cancer. |access-date=2015-05-07 |archive-url=https://web.archive.org/web/20161204160326/http://www.sirweb.org/patients/liver-cancer/ |archive-date=2016-12-04 |url-status=dead }}</ref><ref name="Pereira2012">{{Cite journal|doi=10.1007/s00270-012-0340-1|title=Standards of Practice: Guidelines for Thermal Ablation of Primary and Secondary Lung Tumors|year=2012|last1=Pereira|first1=Philippe L.|last2=Salvatore|first2=Masala|author3=Cardiovascular Interventional Radiological Society of Europe (CIRSE)|journal=CardioVascular and Interventional Radiology|volume=35|issue=2|pages=247–254|pmid=22271076|s2cid=20280474|doi-access=free}}</ref> Interventional oncology treatments are routinely carried out by interventional radiologists in appropriate settings and facilities.<ref>[https://www.rcr.ac.uk/interventional-oncology-guidance-service-delivery-0 The Royal College of Radiologists UK. Interventional Oncology: Guidance for Service delivery]</ref>
== Procedures performed ==
Interventional oncology procedures are generally divided between diagnostic procedures that help obtain tissue diagnosis of suspicious neoplasms and therapeutic ones that aim to cure or palliate the tumour. Therapeutic interventional oncology procedures may be classified further into ablation techniques that destroy neoplastic tissues by delivery of some form of heat, cryo or electromagnetic energy and embolization techniques that aim to occlude the blood vessels feeding the tumour and thereby destroy it by means of ischemia. Both ablation and embolization techniques are minimally invasive treatment, i.e. they may be delivered through the skin (in a percutaneous way) without the need for any skin incisions or other form of open surgery. Hence, most treatments are nowadays offered as day case or outpatient appointments and patients may enjoy rapid recovery and minimal pain and discomfort with low rates of complications.<ref>Cardiovascular and Interventional Radiological Society of Europe, "[http://cirse.org/?pid=1010 IR Procedures]"</ref>
=== Diagnostic techniques === * Fine-needle aspiration: biopsy with a fine needle trying to obtain tissue diagnosis by examining the tumour cells. * Core needle biopsy: similar to fine-needle aspiration, only involving the use of larger needles to excise the tissue. * Vacuum-assisted biopsy: similar to core needle aspiration but using vacuum assistance to gather the sample. Vacuum assisted breast biopsy may provide a high diagnostic yield in case of breast tumours.
=== Image-guided tumor ablation === Uses different types of energy to burn (radiofrequency ablation (RFA) and microwave ablation (MWA)), deliver electrical fields/electroporate (irreversible electroporation(IRE)) or freeze (cryoablation) solid tumors resulting in tumor cell death. Ablation techniques can be performed throughout the body such as in the lung,<ref>{{Cite web|url=https://www.nhs.uk/news/cancer/radiofrequency-ablation-for-lung-cancer/|title=Radiofrequency ablation for lung cancer|date=2017-08-21|website=nhs.uk|access-date=2019-10-29|archive-date=2020-09-27|archive-url=https://web.archive.org/web/20200927190213/https://www.nhs.uk/news/cancer/radiofrequency-ablation-for-lung-cancer/|url-status=dead}}</ref> liver,<ref>{{Cite web|url=https://www.radiologyinfo.org/en/info.cfm?pg=rfaliver|title=Radiofrequency Ablation (RFA) {{!}} Microwave Ablation (MWA) - Liver Tumors|last=Radiology (ACR)|first=Radiological Society of North America (RSNA) and American College of|website=www.radiologyinfo.org|access-date=2019-10-29}}</ref><ref>{{Cite journal|url=https://clinicaltrials.gov/ct2/show/NCT00617981|title=Phase 3 Study of ThermoDox With Radiofrequency Ablation (RFA) in Treatment of Hepatocellular Carcinoma (HCC) - Full Text View - ClinicalTrials.gov|website=clinicaltrials.gov|date=24 March 2017|access-date=2019-10-29}}</ref> kidney,<ref>{{Cite journal|last1=El Dib|first1=Regina|last2=Touma|first2=Naji J.|last3=Kapoor|first3=Anil|date=August 2012|title=Cryoablation vs radiofrequency ablation for the treatment of renal cell carcinoma: a meta-analysis of case series studies|journal=BJU International|volume=110|issue=4|pages=510–516|doi=10.1111/j.1464-410X.2011.10885.x|issn=1464-410X|pmid=22304329|s2cid=36726814|doi-access=free|hdl=11449/41070|hdl-access=free}}</ref> prostate,<ref>{{Cite web|url=https://www.cancer.org/cancer/prostate-cancer/treating/cryosurgery.html|title=Cryotherapy for Prostate Cancer|website=www.cancer.org|access-date=2019-10-29}}</ref> breast,<ref>{{Cite journal|last=Sabel|first=Michael S.|date=July 2014|title=Nonsurgical ablation of breast cancer: future options for small breast tumors|journal=Surgical Oncology Clinics of North America|volume=23|issue=3|pages=593–608|doi=10.1016/j.soc.2014.03.009|issn=1558-5042|pmid=24882353}}</ref> bone,<ref>{{Cite journal|last1=Santiago|first1=Fernando Ruiz|last2=del Mar Castellano García|first2=María|last3=Montes|first3=Jose Luis Martínez|last4=García|first4=Manuel Ruiz|last5=Fernández|first5=Juan Miguel Tristán|date=2009-01-07|title=Treatment of bone tumours by radiofrequency thermal ablation|journal=Current Reviews in Musculoskeletal Medicine|volume=2|issue=1|pages=43–50|doi=10.1007/s12178-008-9042-3|issn=1935-973X|pmc=2684952|pmid=19468917}}</ref> and other organs using image guidance to place a needle/probe through the skin into the target tissue.
* Chemical ablation: one of the earliest ablative techniques involving the injection of substances such as ethanol or acetic acid into a tumour to cause protein denaturation and cell death. *Radiofrequency ablation: tissue destruction through delivery of electricity that produces ionic friction. **Radiofrequency ablation video demonstration: https://www.youtube.com/watch?v=8Xu0mxkLSzE *Irreversible electroporation: delivery of electrical fields to disrupt cellular membranes and cause cell death or apoptosis or enhance targeted drug delivery. **Irreversible electroporation video demonstration: https://www.youtube.com/watch?v=NL-IIq-c3Ic *Cryoablation: instant cell death by tissue freezing to temperatures as low as -20 Celsius. **Cryoablation video demonstration: https://www.youtube.com/watch?v=goLRh3UX0vM *Microwave ablation: electromagnetic energy produces high frequency oscillation of water molecules leading to tissue coagulation by heat. **Microwave ablation video demonstration: https://www.youtube.com/watch?v=uPcU7HFumIk *High-intensity focused ultrasound (HIFU): targeted beam of focused ultrasonic waves that accumulates high energy and burns the tissue.<ref>{{Cite journal|doi = 10.1148/rg.336125162|title = MR Imaging–guided Focused Ultrasound for Treatment of Bone Metastasis|year = 2013|last1 = Napoli|first1 = Alessandro|last2 = Anzidei|first2 = Michele|last3 = Marincola|first3 = Beatrice Cavallo|last4 = Brachetti|first4 = Giulia|last5 = Noce|first5 = Vincenzo|last6 = Boni|first6 = Fabrizio|last7 = Bertaccini|first7 = Luca|last8 = Passariello|first8 = Roberto|last9 = Catalano|first9 = Carlo|journal = Radiographics|volume = 33|issue = 6|pages = 1555–1568|pmid = 24108551}}</ref> * Laser ablation (Interstitial laser therapy): tissue coagulation by a laser beam.<ref>{{Cite journal|pmid = 15856810|year = 2005|last1 = Gangi|first1 = A.|last2 = Basile|first2 = A.|last3 = Buy|first3 = X.|last4 = Alizadeh|first4 = H.|last5 = Sauer|first5 = B.|last6 = Bierry|first6 = G.|title = Radiofrequency and laser ablation of spinal lesions|journal = Seminars in Ultrasound, CT and MRI|volume = 26|issue = 2|pages = 89–97|doi = 10.1053/j.sult.2005.02.005}}</ref>
=== High-intensity focused ultrasound (HIFU) === Uses a machine that emits high frequency sound waves to kill cancer cells and provide relief for tumor-related pain, such as in the bone.
=== Embolisation therapies === * Transarterial embolization (TAE)/bland embolization: Injection of embolic material (microparticles, alcohol, glue) through a catheter into the arteries feeding a tumor in order to completely occlude the tumor's blood supply and cause cell death. The most common indication is for treatment of unresectable liver cancer (hepatocellular carcinoma).<ref>{{Cite journal|last1=Shah|first1=Rajesh P.|last2=Brown|first2=Karen T.|last3=Sofocleous|first3=Constantinos T.|date=October 2011|title=Arterially directed therapies for hepatocellular carcinoma|journal=American Journal of Roentgenology|volume=197|issue=4|pages=W590–602|doi=10.2214/AJR.11.7554|issn=1546-3141|pmid=21940531}}</ref> * Trans(catheter) arterial chemoembolization (TACE): Injection of a chemotherapy agent often with microparticles through a catheter into arteries feeding a tumor that both delivers chemotherapy and blocks the blood supply to the tumor to cause cell death<ref name=p23357493>{{Cite journal|last1=Salem|first1=Riad|last2=Lewandowski|first2=Robert J.|date=June 2013|title=Chemoembolization and radioembolization for hepatocellular carcinoma|journal=Clinical Gastroenterology and Hepatology|volume=11|issue=6|pages=604–611|doi=10.1016/j.cgh.2012.12.039|doi-access=free|issn=1542-7714|pmc=3800021|pmid=23357493}}</ref> **Can be performed in different ways: ***Conventional transarterial chemoembolization (cTACE): Injection of lipiodol with high dose chemotherapy with or without microparticles directly into the tumor-feeding arteries.<ref>{{Cite web|url=https://www.cancercenter.com/treatment-options/chemotherapy/regional-therapies|title=Chemotherapy Delivery Options: Benefits of Regional Therapies|date=2018-10-17|website=Cancer Treatment Centers of America|access-date=2019-10-29}}</ref> ***Drug-eluting bead chemoembolization (DEB-TACE): delivery of microparticles that are themselves loaded with the chemotherapy agent – typically doxorubicin or irinotecan.<ref name=p23357493/> *Selective internal radiation therapy (also known as SIRT or Y-90 radioembolization or TARE): Injection of small beads loaded with a radioactive isotope, Yittrium-90 (Y-90), into blood vessels feeding a tumor in order to deliver a lethal dose of radiation causing cell death.<ref>{{Cite journal|last1=Al-Adra|first1=D. P.|last2=Gill|first2=R. S.|last3=Axford|first3=S. J.|last4=Shi|first4=X.|last5=Kneteman|first5=N.|last6=Liau|first6=S.-S.|date=January 2015|title=Treatment of unresectable intrahepatic cholangiocarcinoma with yttrium-90 radioembolization: a systematic review and pooled analysis|journal=European Journal of Surgical Oncology |volume=41|issue=1|pages=120–127|doi=10.1016/j.ejso.2014.09.007|issn=1532-2157|pmc=4316196|pmid=25449754}}</ref> Can be performed in a segmental (radiation segmentectomy) or a lobar (Radiation Lobectomy) fashion. Radiation lobectomy is commonly performed with the goal of inducing growth of the non-diseased lobe in order to have adequate liver function necessary to undergo surgical resection. **Y-90 video demonstration: https://www.youtube.com/watch?v=YndyQkSZl5I * Intra-arterial chemotherapy: high dose chemotherapy is administered directly into the tumor-feeding arteries.<ref>[http://www.cancercenter.com/treatments/intra-arterial-chemotherapy/ Cancer Treatment Center of America, Intra-Arterial chemotherapy]</ref> *Portal vein embolization (PVE): delivery of embolic material into the portal vein feeding the lobe of liver containing the tumor(s) of interest to induce growth of the non-diseased lobe in order to have adequate liver function necessary to undergo surgical resection of lobe containing the tumor(s).<ref>{{Cite journal|last1=May|first1=Benjamin J.|last2=Madoff|first2=David C.|date=June 2012|title=Portal vein embolization: rationale, technique, and current application|journal=Seminars in Interventional Radiology|volume=29|issue=2|pages=81–89|doi=10.1055/s-0032-1312568|issn=0739-9529|pmc=3444878|pmid=23729977}}</ref>
=== Palliative treatments ===
Interventional oncology has long been used to provide palliative care for patients. IO procedures can help reduce cancer-related pain and improve patients’ quality of life. Tumours can intrude into various ducts and blood vessels of the body, obstructing the vital passage of food, blood or waste. The interventional radiological treatment known as stenting can be used to re-open blockages, for example of the esophagus or bile ducts in cases of esophageal cancer or cholangiocarcinoma, respectively, considerably relieving the patient's adverse symptoms.<ref>{{Cite journal|pmc=2685220|year=2009|last1=Katsanos|first1=K.|last2=Ahmad|first2=F.|last3=Dourado|first3=R.|last4=Sabharwal|first4=T.|last5=Adam|first5=A.|title=Interventional radiology in the elderly|journal=Clinical Interventions in Aging|volume=4|pages=1–15|pmid=19503761}}</ref>
== Diseases treated ==
Interventional oncology (IO) procedures are commonly applied to treat primary or metastatic cancer. IO treatments may be also offered in combination with any of the above oncological therapies in order to augment the therapeutic outcome in more complex or widespread (metastatic) cancer cases. There is a variety of applications of interventional oncological treatments for tumors that arise in the:
* Liver: primary liver tumors such as hepatocellular carcinoma or cholangiocarcinoma and liver metastases are often treated by procedures such as transarterial chemoembolization (TACE), Selective internal radiation therapy (SIRT/Y-90 radioembolization), portal vein embolization, transarterial/bland embolization, or image guided ablation (RFA, MWA, IRE, Cryoablation).<ref>{{Cite web|url=https://www.cancercenter.com/cancer-types/liver-cancer/treatments/interventional-radiology|title=Liver Cancer Interventional Radiology: Minimally Invasive|date=2018-10-05|website=Cancer Treatment Centers of America|access-date=2019-10-29}}</ref> * Lung: lung metastases or inoperable primary lung cancer can be treated by interventional radiology procedures such as image guided ablation (cryoablation, microwave ablation and radiofrequency ablation).<ref>{{Cite journal|last1=Pereira|first1=Philippe L.|last2=Salvatore|first2=Masala|date=April 2012|title=Standards of Practice: Guidelines for Thermal Ablation of Primary and Secondary Lung Tumors|journal= CardioVascular and Interventional Radiology|volume=35|issue=2|pages=247–254|doi=10.1007/s00270-012-0340-1|pmid=22271076|issn=1432-086X|doi-access=free}}</ref> ** Cryoablation of lung cancer video demonstration: https://www.youtube.com/watch?v=RH4po_14mDY *Kidney: kidney tumors such as renal cell carcinoma can be treated with image guided ablation (RFA, MWA, cryotherapy) with similar results to partial nephrectomy.<ref>{{Cite journal|last1=Rivero|first1=J. Ricardo|last2=De La Cerda|first2=Jose|last3=Wang|first3=Hanzhang|last4=Liss|first4=Michael A.|last5=Farrell|first5=Ann M.|last6=Rodriguez|first6=Ronald|last7=Suri|first7=Rajeev|last8=Kaushik|first8=Dharam|date=January 2018|title=Partial Nephrectomy versus Thermal Ablation for Clinical Stage T1 Renal Masses: Systematic Review and Meta-Analysis of More than 3,900 Patients|journal=Journal of Vascular and Interventional Radiology |volume=29|issue=1|pages=18–29|doi=10.1016/j.jvir.2017.08.013|issn=1535-7732|pmid=29102464}}</ref> Benign kidney tumors such as angiomyolipomas can be treated with transarterial embolization to shrink the tumor size and reduce the risk of rupture/bleeding. Other embolizations are also performed for symptom relief or prior to surgery to reduce bleeding.<ref>{{Cite journal|last1=Foster|first1=Ryan C.B.|last2=Stavas|first2=Joseph M.|date=June 2014|title=Bone and Soft Tissue Ablation|journal=Seminars in Interventional Radiology|volume=31|issue=2|pages=167–179|doi=10.1055/s-0034-1373791|issn=0739-9529|pmc=4078106|pmid=25053865}}</ref> *Bone (or as metastases): bone metastases located in the spine, pelvis and long bones can be treated with image guided ablative techniques (RFA, MWA, cryoablation, electroportation) with or without injection of cement (cementoplasty) to stabilize the bone. These treatments may be palliatively for bone metastases pain or for some cases such as osteoid osteoma can curatively treat tumors. Embolizations are also performed for prior to surgery to reduce bleeding.<ref>{{Cite journal|last1=Kurup|first1=Anil Nicholas|last2=Callstrom|first2=Matthew R.|date=2013-12-01|title=Ablation of Musculoskeletal Metastases: Pain Palliation, Fracture Risk Reduction, and Oligometastatic Disease|url=https://www.techvir.com/article/S1089-2516(13)00068-1/abstract|journal=Techniques in Vascular & Interventional Radiology|language=English|volume=16|issue=4|pages=253–261|doi=10.1053/j.tvir.2013.08.007|issn=1089-2516|pmid=24238380|url-access=subscription}}</ref> *Breast: for small, solitary breast cancer image guided ablative techniques are used to treat tumors, however their efficacy versus surgical resection has not yet been studied.<ref>{{Cite journal|last1=Nguyen|first1=Tiffany|last2=Hattery|first2=Eleanor|last3=Khatri|first3=Vijay P.|date=May 2014|title=Radiofrequency ablation and breast cancer: a review|journal=Gland Surgery|volume=3|issue=2|pages=128–135|doi=10.3978/j.issn.2227-684X.2014.03.05|issn=2227-684X|pmc=4115759|pmid=25083506}}</ref> *Prostate: inoperable tumors can be treated with image guided ablative techniques and more recently irreversible electroporation. **Irreversible electroporation video demonstration: https://www.mskcc.org/videos/irreversible-electroporation-nanoknife-treat-prostate-tumors *Pancreas: inoperable, or borderline resectable, locally advanced pancreatic adenocarcinoma can be treated with irreversible electroporation<ref>{{Cite journal|last=Martin|first=Robert C. G.|date=June 2015|title=Use of irreversible electroporation in unresectable pancreatic cancer|journal=Hepatobiliary Surgery and Nutrition|volume=4|issue=3|pages=211–215|doi=10.3978/j.issn.2304-3881.2015.01.10|issn=2304-3881|pmc=4465607|pmid=26151062}}</ref>
== Milestones ==
* 1930 – First therapeutic embolization procedure (of a carotid-cavernous fistula); described by Brooks.<ref>Barney Brooks, The Treatment of Traumatic Arteriovenous Fistula, Southern Medical Journal. 01/1930; 23(2):100-106.</ref> * 1960s – Radioisotopes such as Yttrium-90 (Y90) started to be investigated for the use in cancer treatments. * 1966 – Embolization therapy to treat tumors and spinal cord vascular malformations by blocking the blood flow. * 1969 – The catheter-delivered stenting technique and prototype stent. * 1970s – Embolisation agents started to be used in palliative care to treat liver tumors. * 1980 – Cryoablation to freeze liver tumors. * 1983 – Laser interstitial thermal therapy first performed on a tumour by Bown.<ref>{{cite journal|vauthors=Bown SG|title=Phototherapy in tumors|journal= World Journal of Surgery|volume=7|issue=6|pages=700–709|date=1983|doi=10.1007/BF01655209|pmid=6419477|s2cid=2574459}}</ref> * 1985 – Self-expanding stents are developed for vascular and oncological applications. * 1990 – Radiofrequency ablation (RFA) technique for liver tumors. * 1990s – Treatment of bone and kidney tumors by embolization. * 1990s – RFA for soft tissue tumors, i.e., bone, breast, kidney, lung and liver cancer. * 1997 – Intra-arterial delivery of tumor-killing viruses and gene therapy vectors to the liver. * 1997 – HIFU first used to treat prostate cancer. * 2012 – Pioneering liver chemoperfusion study reported by Delcath for disseminated liver metastases.<ref>{{cite journal|last1=Deneve|first1=Jeremiah L.|last2=Choi|first2=Junsung|display-authors=et al|date=December 2012|title=Chemosaturation with Percutaneous Hepatic Perfusion for Unresectable Isolated Hepatic Metastases from Sarcoma|journal= CardioVascular and Interventional Radiology|volume=35|issue=6|pages=1480–1487|doi=10.1007/s00270-012-0425-x|pmid=22699779|s2cid=25073546}}</ref>
== Benefits ==
While the surgical resection of tumours is generally accepted to offer the best long-term solution, it is often not possible due to the size, number or location of the tumour. IR therapies may be applied to shrink the tumour, making a surgical or interventional treatment possible. Some patient groups may also be too weak to undergo open surgery. IR treatments can be applied in these complex cases to provide effective and milder forms of treatment. Interventional oncological techniques can also be used in combination with other treatments to help increase their efficacy. For example, IO techniques can be used to shrink large tumours making them easier to excise. Chemotherapeutic drugs can also be administered intra-arterially, increasing their potency and removing the harsh effects of system-wide application.
Patients can greatly benefit from IO treatments. The minimally invasive nature of the treatments means they cause less pain, fewer side effects and shorter recovery times. Many IO procedures can be performed on an outpatient basis, freeing up hospital beds and reducing costs.<ref>{{cite web|work=European Conference of Interventional Oncology|url=http://ecio.org/index.php?pid=8|title=What is IO?|publisher=Cardiovascular and Interventional Radiological Society of Europe|url-status=dead|archive-url=https://web.archive.org/web/20150313062616/http://ecio.org/index.php?pid=8|archive-date=2015-03-13}}</ref>
== Further considerations ==
=== Multidisciplinary approach ===
Cancer is a multifaceted disease group that requires a multidisciplinary approach to treatment. Numerous studies have shown that cancer patients treated in multidisciplinary environments benefit greatly from the combined expertise. Interventional Radiologists are seen as playing a major role in multidisciplinary cancer teams where they provide innovative solutions to improve combined therapies and to treat complications.<ref>{{Cite journal|doi = 10.1038/nrclinonc.2014.211|title = Interventional oncology in multidisciplinary cancer treatment in the 21st century|year = 2015|last1 = Adam|first1 = Andreas|last2 = Kenny|first2 = Lizbeth M.|journal = Nature Reviews Clinical Oncology|volume = 12|issue = 2|pages = 105–113|pmid = 25445561|s2cid = 7689364}}</ref>
=== Patient selection ===
Proper patient selection is the key element for the success of any medical procedure and improper conduct can have fatal consequences. Patient selection protocols must be strictly followed before treating patients with IO procedures.
=== Radiation protection ===
IO treatments are carried out under image guidance. For this reason practitioners must have attained solid training in radiation protection.
== See also ==
== References ==
{{reflist}}
== External links == * [http://www.sirweb.org Society of Interventional Radiology] * [http://www.cirse.org Cardiovascular and Interventional Radiological Society of Europe] * [http://www.iasios.org IASIOS- International Accreditation System for Interventional Oncology] * [http://www.esir.org ESIR Online] * [http://www.ecio.org ECIO - European Conference on Interventional Oncology Services] * [http://www.iset.org/oncology CIO - Annual Symposium on Clinical Interventional Oncology]
Category:Interventional radiology Category:Branches of oncology