Fructuronate reductase

{{infobox enzyme | Name = fructuronate reductase | EC_number = 1.1.1.57 | CAS_number = 9028-44-8 | GO_code = 0008866 | image = | width = | caption = }} In enzymology, '''fructuronate reductase''' ({{EC number|1.1.1.57}}) is an enzyme that catalyzes the chemical reaction

{{chemrxn|width=60%| {{chemrxn/cpd|qid=Q27104257|caption=D-mannonic acid }} {{chemrxn/txt|+ NAD⁺}} {{chemrxn/arw|direction=reversible|fwd_out={{chem2|H+}}|rev_in={{chem2|H+}} }} {{chemrxn/cpd|qid=Q27120874|caption=keto-D-fructuronic acid }} {{chemrxn/txt|+ NADH}} }}

The two substrates of this enzyme are D-mannonic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are D-fructuronic acid (shown in its keto form), reduced NADH, and a proton.<ref>{{KEGG enzyme|1.1.1.57}}</ref><ref>{{cite journal |author1 = Hickman J |author2 =Ashwell G | date = 1960 | title = Uronic acid metabolism in bacteria. II. Purification and properties of D-altronic acid and D-mannonic acid dehyrogenases in ''Escherichia coli'' | journal = J. Biol. Chem. | volume = 235 |issue =6 | pages = 1566&ndash;1570 |doi =10.1016/S0021-9258(19)76841-0 |pmid =14401695 |doi-access =free }}</ref><ref>{{cite journal | vauthors = Kilgore WW, Starr MP | date = 1959 | title = Catabolism of galacturonic and glucuronic acids by ''Erwinia carotovora'' | journal = J. Biol. Chem. | volume = 234 | issue = 9 | pages = 2227&ndash;35 | doi = 10.1016/S0021-9258(18)69789-3 | doi-access = free | pmid = 14409051 }}</ref>

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is '''D-mannonate:NAD⁺ 5-oxidoreductase'''. Other names in common use include '''mannonate oxidoreductase''', '''mannonic dehydrogenase''', '''D-mannonate dehydrogenase''', and '''D-mannonate:NAD⁺ oxidoreductase'''. This enzyme participates in pentose and glucuronate interconversions.

==References== {{reflist}}

{{Alcohol oxidoreductases}} {{Enzymes}} {{Portal bar|Biology|border=no}}

Category:EC 1.1.1 Category:NADH-dependent enzymes Category:Enzymes of unknown structure

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